The effect of zinc on ethanol-induced oxidative stress in rat liver

Caglar, Oznur Mertoglu; Bi̇lgi̇han, Ayşe; Turkcu, Ummuhani Ozel; Biberoğlu, Gürsel; Take, Gülnur

doi:10.5505/tjb.2012.49469

Cited by 8 publications

(2 citation statements)

References 37 publications

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“…Histological changes on kidney which were different from those effects on liver, however Zn reduced histological changes either in (H.D) or (L.D). These results were in conformity with those reported by Duran et al [17] who reported that Zn supplementation might have a protective effect from cigarette smoke-induced nephrotoxicity in rats and Mansour and Mossa [37] who observed that Zn had resulted in pronounced ameliorating effect against chlorpyrifos-induced kidneys damage in male and female rats. Also effects of S.honey with Zn in (H.D) or (L.D) together reduced IM effect that induced histological changes on kidney.…”

Section: Discussionsupporting

confidence: 93%

“…It exerts its antioxidant effects indirectly by maintaining membrane structures, involving in the structure of SOD increasing the metallothionein concentrations and competing with redox reactive metals, iron and cuprous for critical binding sites [54]. It founds studies of indicate to role of Zn as antioxidant activity against toxicity that induced hepatorenal and hematological toxicity by Al-Sabaawy [6], Ambali et al [7], Duran et al [17], El-Ashmony [19], Kilic et al [32], Mansour and Mossa [37] and Samir et al [45].…”

Section: Introductionmentioning

confidence: 99%

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The protective effect of Sider honey and Zinc on imidacloprid induced hepatorenal and hematological toxicity in rats

Al-Awar¹,

Gumaih²,

Al-Ameri³

et al. 2018

Journal of Natural Sciences, Life and Applied Sciences

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هدفت الدراسة الحالية إلى تقييم قدرة مضادات الأكسدة; عسل السدر والزنك (منفصلة ومجتمعة) لمدة 30 يوماً في التخفيف من الأضرار الكبدية والكلوية والدموية المحدثة بالمبيد الحشري الإيميداكلوبريد في الجرذان. معاملة الجرذان بالإيميداكلوبرايد عن طريق الفم أدت إلى زيادة معنوية في نشاط إنزيمات الكبد (AST & ALT) ومؤشرات وظائف الكلى (اليوريا, حمض اليوريك والكرياتينيين), ومستويات الدهون (الكوليسترول الكلي, الدهون الثلاثية و الدهون منخفضة الكثافة), صاحب ذلك انخفاض معنوي في مستوى البروتين الكلي والألبيومين والدهون مرتفعة الكثافة, بالإضافة إلى ذلك انخفاض معنوي في عدد كريات الدم الحمراء والصفائح الدموية ومستوى الهيموجلوبين مع زيادة معنوية في عدد كريات الدم البيضاء, وكشفت المقاطع النسيجية للكبد والكلى أضراراً كبيرةً بعد معاملتها بالإيميداكلوبريد. من ناحية أخرى, أدى النظام الغذائي المكمل لكلٍ من عسل السدر والزنك بجرعة منخفضة (منفصلة ومجتمعة) عند استخدامهما كمرافق وقائي إلى تحسين الآثار الضارة للإيميداكلوبريد على كل المؤشرات الكيموحيوية والنسيجية المدروسة, والذي قد يكون عائداً لخصائصها المضادة للأكسدة وقدرتها على كسح الجذور الحرة, في حين أن المعاملة بالزنك بجرعة عالية لوحده أو في تركيبة مع عسل السدر سبب آثاراً سلبية على الكبد, وبالتالي هنالك حاجة إلى المزيد من الدراسات لتحديد الجرعات المناسبة من العسل والزنك كمضادات للأكسدة بدون آثار جانبية.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The protective effect of Sider honey and Zinc on imidacloprid induced hepatorenal and hematological toxicity in rats

Al-Awar¹,

Gumaih²,

Al-Ameri³

et al. 2018

Journal of Natural Sciences, Life and Applied Sciences

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Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice

et al. 2017

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In the present study, we investigated the concentration-dependent effect of zinc (Zn) supplementation on the adult hippocampus in a high-fat diet (HFD)-fed obese mouse model. Four-weeks after HFD- and control diet (CD)-feeding, mice were provided with low (15 ppm) or high (60 ppm) doses of Zn in their drinking water for additional 4 more weeks along with their respective diets. Compared to the CD-fed mice, HFD-feeding elicited the reduction of neurogenic markers such as nestin, Ki67, doublecortin (DCX), and 5-bromo-2'-deoxyuridine (BrdU) in the dentate gyrus. Additionally, HFD-feeding reduced the levels of synaptic markers (synaptophysin and N-methyl-D-aspartate receptor) and brain-derived neurotrophic factor (BDNF), while lipid peroxidation was significantly increased in the hippocampus of HFD-fed mice. Against detrimental effects of high-dose Zn, low-dose Zn supplementation in CD-fed mice did not yield any remarkable changes in these parameters. Interestingly, administration of low doses of Zn to HFD-induced obese mice prominently ameliorated HFD-induced changes in neurogenic, synaptic plasticity markers and BDNF levels as well as lipid peroxidation in the hippocampus. In contrast, high-dose Zn supplementation in HFD-fed mice exacerbated the reduction of markers for neurogenesis and synaptic plasticity as well as BDNF levels, but not 4-HNE levels, in the hippocampus. These results suggest that low-dose Zn supplementation in obese mice could reverse the HFD-induced reduction in neurogenic and synaptic marker proteins in the hippocampus by reducing lipid peroxidation and improving BDNF expression, while high-dose Zn supplementation exacerbates the reduction of neurogenesis by affecting synaptic markers and BDNF levels in the hippocampus.

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Zinc Might Prevent Heat-Induced Hepatic Injury by Activating the Nrf2-Antioxidant in Mice

Wang

Cao

et al. 2015

Biol Trace Elem Res

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Zinc (Zn) is generally known to be an essential trace element with growth-promoting and antioxidant activities. The present study was performed to clarify the role of Zn in the livers of heat-treated mice. Eight-week-old male mice were divided into control (Con), heat treatment (HT) and heat treatment plus zinc groups (HT + Zn) and were fed diets containing 60, 60, or 300 mg/kg Zn (zinc sulfate), respectively. After 30 days of feeding on their respective diets, the control group was maintained at a controlled temperature (25 °C), whereas the HT and HT + Zn groups were exposed to an elevated ambient temperature (40-42 °C) for 2 h each day. After heat exposure for seven consecutive days, sera and liver tissues were collected. The mice in the HT group exhibited reduced liver weights and lower hepatosomatic indices. Histological findings revealed that the hepatocytes of the HT group were subjected to serious damage and exhibited irregular arrangements and nuclear pyknosis. Moreover, in the HT group, the hepatic malondialdehyde levels were significantly increased, while the serum alkaline phosphatase levels, hepatic copper/zinc-superoxide dismutase (CuZn-SOD) and glutathione peroxidase activities were significantly reduced compared to those of the control group. However, in the HT + Zn group, the histomorphology of the liver was restored, the serum aspartate aminotransferase (AST) level was significantly decreased, and the hepatic CuZn-SOD activity was significantly increased compared to the HT group. Furthermore, expressions of the hepatic Nrf2 protein and Nrf2, Keap1, and NQO1 genes in the HT + Zn group were not only higher than the HT group but also higher than the control group. Zn might alleviate heat-induced hepatic injury as revealed by restored histomorphology and AST level. Our results further suggest that Zn might exert its protective effects via the activation of the Nrf2-antioxidant pathway.

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The effect of zinc on ethanol-induced oxidative stress in rat liver

Cited by 8 publications

References 37 publications

The protective effect of Sider honey and Zinc on imidacloprid induced hepatorenal and hematological toxicity in rats

The protective effect of Sider honey and Zinc on imidacloprid induced hepatorenal and hematological toxicity in rats

Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice

Zinc Might Prevent Heat-Induced Hepatic Injury by Activating the Nrf2-Antioxidant in Mice

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