Effects of dietary vitamin E, C and soybean oil supplementation on antioxidant enzyme activities in liver and muscles of rats

Shireen, Kaniz F.; Pace, Ralphenia D.; Mahboob, M.; Khan, Abu T.

doi:10.1016/j.fct.2008.07.015

Cited by 58 publications

(35 citation statements)

References 50 publications

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“…While this may indicate that dietary micronutrients primarily influence the non-enzymatic antioxidant defence system, we cannot rule out the possibility that our dietary treatment had an effect on other (nonmeasured) antioxidant enzymes (e.g. catalase or gluthatione reductase; Shireen et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Interactive effects of early and later nutritional conditions on the adult antioxidant defence system in zebra finches

Noguera

Monaghan

Metcalfe

2015

Journal of Experimental Biology

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In vertebrates, antioxidant defences comprise a mixture of endogenously produced components and exogenously obtained antioxidants that are derived mostly from the diet. It has been suggested that early-life micronutritional conditions might influence the way in which the antioxidant defence system operates, which could enable individuals to adjust the activity of the endogenous and exogenous components in line with their expected intake of dietary antioxidants if the future environment resembles the past. We investigated this possibility by experimentally manipulating the micronutrient content of the diet during different periods of postnatal development in the zebra finch (Taeniopygia guttata). Birds that had a low micronutrient diet during the growth phase initially had a lower total antioxidant capacity (TAC) than those reared under a high micronutrient diet, but then showed a compensatory response, so that by the end of the growth phase, the TAC of the two groups was the same. Interestingly, we found an interactive effect of micronutrient intake early and late in development: only those birds that continued with the same dietary treatment (low or high) throughout development showed a significant increase in their TAC during the period of sexual maturation. A similar effect was also found in the level of enzymatic antioxidant defences (glutathione peroxidase; GPx). No significant effects were found in the level of oxidative damage in lipids [malondialdehyde (MDA) levels]. These findings demonstrate the importance of early and late developmental conditions in shaping multiple aspects of the antioxidant system. Furthermore, they suggest that young birds may adjust their antioxidant defences to enable them to 'thrive' on diets rich or poor in micronutrients later in life.

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Section: Discussionmentioning

confidence: 99%

Interactive effects of early and later nutritional conditions on the adult antioxidant defence system in zebra finches

Noguera

Monaghan

Metcalfe

2015

Journal of Experimental Biology

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“…Vitamin E and vitamin C separately increase the activities of antioxidant enzymes in various tissues of rats, especially liver tissues and also vitamin E on bone marrow, where the different blood cells are formed (Shireen et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Determination of blood indices of albino rats treated with aluminum chloride and investigation of antioxidant effects of vitamin E and C

Aziz

Zabut²

2011

Egypt. J. Bio.

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The current study aims to investigate hematological and biochemical blood indices of albino rats administrated aluminum chloride (AlCl 3 ) for eight weeks, and to study the therapeutic effects of vitamin E and C. AlCl 3 decreased the total red blood cell count (by 18%), hemoglobin (7%) and hematocrit (20%), and increased white blood cell count (67%), lymphocytes (29%), mean corpuscular volume (14%), mean corpuscular hemaglobin (6%) and platelets (33%). Administration of vitamin E with or without vitamin C failed to restore levels of red blood cell counts, hematocrit, mean corpuscular volume, mean corpuscular hemaglobin or platelets, but vitamin E on its own restored levels of white blood cells, hemaglobin and lymphocytes.AlCl 3 decreased serum glucose levels by 30%, and increased triglyceride (28%) and cholesterol (20%) levels; neither vitamin treatments restored the levels of these components. AlCl 3 increased levels of urea (12%), uric acid (77%) and creatinine (25%) compared to the controls, and vitamin E separately or together with vitamin C restored the levels of these nitrogen compounds.The activities of alanine aminotransferase, alkaline phosphatase, and aspartate aminotransferase were also increased by the AlCl 3 treatment; the first two but not aspartate aminotransferase were restored by vitamin E separately or together with vitamin C.We conclude that vitamin E separately or together with vitamin C suppressed cytogenetic injury and damage to some biochemical pathways of rat organs induced by AlCl 3 .

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“…Therefore, the use of antioxidants can be considred as the alternative method for chelation therapy. Accordingly, interest has recently grown in the role of natural antioxidants to prevent oxidative damage, as it is the main factor in the pathophysiology of various health disorders (Shireen et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of fermented sardinelle protein hydrolysates on hypercaloric diet induced hyperglycemia, oxidative stress and deterioration of kidney function in wistar rats

et al. 2017

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This study investigated the potential effects of fermented sardinelle protein hydrolysates (FSPHs) obtained by two proteolytic bacteria, Bacillus subtilis A26 (FSPH-A26) and Bacillus amyloliquefaciens An6 (FSPHAn6), on hypercaloric diet (HCD) induced hyperglycemia and oxidative stress in rats. Effects of FSPHs on blood glucose level, glucose tolerance, a-amylase activity and hepatic glycogen content were investigated, as well as their effect on the oxidative stress state. Biochemical findings revealed that, while undigested sardinelle proteins did not exhibit hypoglycemic activity, oral administration of FSPHs to HCD-fed rats reduced significantly a-amylase activity as well as glycemia and hepatic glycogen levels. Further, the treatment with FSPHs improved the redox status by decreasing the levels of lipid peroxidation products and increasing the activities of the antioxidant enzymes (superoxide dismutase, glutathione peroxidase and catalase) and the level of glutathione in the liver and kidneys, as compared to those of HCD-fed rats. FSPHs were also found to exert significant protective effects on liver and kidney functions, evidenced by a marked decrease in alkaline phosphatase activity and a modulation of creatinine and uric acid contents. These results indicated the beneficial effect of FSPHs on the prevention from hyperglycemia and oxidative stress.

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Effects of dietary vitamin E, C and soybean oil supplementation on antioxidant enzyme activities in liver and muscles of rats

Cited by 58 publications

References 50 publications

Interactive effects of early and later nutritional conditions on the adult antioxidant defence system in zebra finches

Interactive effects of early and later nutritional conditions on the adult antioxidant defence system in zebra finches

Determination of blood indices of albino rats treated with aluminum chloride and investigation of antioxidant effects of vitamin E and C

Beneficial effects of fermented sardinelle protein hydrolysates on hypercaloric diet induced hyperglycemia, oxidative stress and deterioration of kidney function in wistar rats

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