Effects of Dietary Restriction on Growth, Neurobehavior, and Reproduction in Developing Kunmin Mice

Wu, Aiguo; Wan, Fada; Sun, Xiufa; Liu, Yugu

doi:10.1093/toxsci/70.2.238

Cited by 22 publications

(13 citation statements)

References 34 publications

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“…Why the Npr2 cn-2J/cn-2J mice do not suffer from these GI problems is not clear, but may depend on the respective genetic backgrounds. These conclusions about the importance of nutrition are consistent with reports on the role of nutrition in growth and development of the reproductive system [16]; moreover, dietary restriction is known to impact negatively on testicular volume, weight and function [18,19]. …”

Section: Discussionsupporting

confidence: 89%

“…For example, Npr2 slw/slw mutants display gastrointestinal (GI) dysfunctions and high pre-weaning death, due to lack of CNP/NPR-B signaling [6,14]. In the case of the few surviving Npr2 slw/slw mice, the GI disorders might cause nutritional restriction, which is known to contribute to aberrant spermatogenesis and reduced number of germ cells [15,16]. …”

Section: Resultsmentioning

confidence: 99%

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Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility

Sogawa

Fujiwara

Tsukamoto³

et al. 2014

Reprod Biol Endocrinol

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BackgroundC-type natriuretic peptide (CNP) signaling through its receptor natriuretic peptide receptor B (NPR-B) is a key molecule for mammalian reproduction, and known to play important roles in female fertility. However, the function of these peptides in mouse male reproduction remains largely unknown. To determine the role of CNP/NPR-B signaling in male reproduction we investigated phenotype of Npr2-deficient short-limbed-dwarfism (Npr2 slw/slw ) mice, which have been shown to have gastrointestinal (GI) abnormalities.FindingsIn homozygous Npr2 slw/slw mice, spermatogenesis is developmentally delayed at both 2 and 4 weeks of age, with vacuolation and degenerating apoptotic germ cells being observed at 3 weeks age. However, the adult Npr2 slw/slw mice exhibited apparently normal spermatogenesis, albeit with some aberrant spermatids, suggesting that developmental delay was overcome. In addition, the adult Npr2 slw/slw mice showed abnormal penile morphology (paraphimosis).ConclusionsThe potential role of CNP signaling via the NPR-B receptor in male fertility appears to be mediated not through germ-cell development, but may be through maintenance of normal penile function.

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Section: Discussionsupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility

Sogawa

Fujiwara

Tsukamoto³

et al. 2014

Reprod Biol Endocrinol

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“…1b), the resulting decrease in energy intake was sufficient to cause impaired growth of ER mice relative to ES mice, but only through preinfection phase I and early postinfection phase IIa. This pattern is similar to that observed for female Kunmin mice, whose mass gain was retarded when their dietary intake was reduced by 20% but who reached masses comparable to those of control mice after 3 months (Wu et al 2002). It should be noted that the response of rodents to energyrestricted diets appears to be dependent on the feeding regimen.…”

Section: Discussionsupporting

confidence: 83%

Mild energy restriction alters mouse–nematode transmission dynamics in free-running indoor arenas

Scott¹,

Dare²,

Tu³

et al. 2005

Can. J. Zool.

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Energy restriction reduces Heligmosomoides polygyrus (Dujardin, 1845) (Nematoda) infection by reducing transmission-related behaviours but prolongs parasite survival by suppressing immune responses in individually housed mice. To determine the relative importance of these two processes in accumulation of worms in mouse populations, 10 female CD1 mice were housed in each of eight indoor arenas with ad libitum access to either an energy-sufficient (ES) diet or an energy-restricted (ER) diet with 20% less metabolizable energy (four arenas per diet). After 3 weeks, H. polygyrus transmission was initiated by introducing larvae onto damp peat trays. Mice adapted to the ER diet through increased food intake and nesting and reduced overall activity; after 6 weeks, nutritional and immunological measures were comparable between diet groups. With continuing exposure to parasite larvae, mice in both ER and ES arenas developed resistance to the incoming larvae; however, mice in the ER arenas accumulated lower worm burdens than mice in the ES arenas despite their increased contact with peat. We suggest that the comparable immunocompetence of mice in the ER and ES arenas enabled the ER mice exposed to higher transmission rates to more rapidly reject the parasites, leading to lower final worm numbers, a pattern frequently observed in other helminth infections.Résumé : Une carence énergétique diminue l'infection par Heligmosomoides polygyrus (Dujardin, 1845) (Nematoda) en réduisant les comportements associés à la transmission, mais prolonge la survie du parasite en supprimant la ré-ponse immunitaire chez les souris logées individuellement. Afin de déterminer l'importance relative de ces deux processus sur l'accumulation de vers dans des populations de souris, nous avons logé 10 souris femelles CD1 dans chacune de huit arènes intérieures (quatre arènes par régime alimentaire) avec un accès ad libitum soit à un régime avec énergie suffisante (ES), soit à un régime réduit avec 20 % de moins d'énergie métabolisable (ER). Au bout de 3 semaines, nous avons initié la transmission d'H. polygyrus en introduisant des larves sur des plateaux de tourbe humide. Les souris se sont adaptées au régime ER en augmentant leur ingestion de nourriture, restant au nid et réduisant leur activité générale; après 6 semaines, les variables nutritionnelles et immunologiques étaient semblables dans les deux groupes expérimentaux. Durant leur exposition prolongée aux vers, les souris des arènes ER et ES ont développé une résistance à l'ingestion continue de larves, mais les souris des arènes ER ont accumulé des charges parasitaires plus faibles que celles des souris dans les arènes ES, malgré leur contact plus grand avec la tourbe. Nous croyons que l'immunocompétence similaire chez les souris des arènes ER et ES a permis aux souris ER exposées à des taux de transmission plus élevées de rejeter plus rapidement les parasites, ce qui explique la charge parasitaire finale plus faible, un phénomène souvent observé dans d'autres infections à helminthes.[Traduit pa...

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“…These limited data, however, exhibit inconsistent results. For example, the male but not female mice at an age of 1 month were fed by 20-35% DR for 3 months (Wu et al, 2002), or after weaning experienced DR for 6 months (Wu et al, 2003), displaying increased learning but not retention in a Y-maze. Herein, the Y-maze task is very different from ours, which has foot shocks in start and error arms.…”

Section: Weight Loss Indexmentioning

confidence: 99%

Food restriction affects Y‐maze spatial recognition memory in developing mice

Chen

et al. 2017

Intl J of Devlp Neuroscience

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The ambiguous effects of food restriction (FR) on cognition in rodents have been mostly explored in the aged brain by a variety of paradigms, in which either rewards or punishments are involved. This study aims to examine the effects of chronic and acute FR with varying intensities on spatial recognition memory in developing mice. We have used a Y-maze task that is based on the innate tendency of rodents to explore novel environments. In chronic FR, mice had 70-30% chow of control for seven weeks. In acute FR, mice were food restricted for 12-48h before the tests. We found that chronic FR had no effect on the preference of mice for novelty in the Y-maze, but severe FR (50-30% of control) caused impairment on spatial recognition memory. The impairment significantly correlated with the slow weight growth induced by FR. Acute FR also did not affect the novelty preference of mice, but either improved or impaired the memory retention. These data suggest chronic FR impairs Y-maze spatial recognition memory in developing mice depending on FR intensity and individual tolerability of the FR. Moreover, acute FR exerts diverse effects on the memory, either positive or negative. Our findings have revealed new insights on the effects of FR on spatial recognition memory in developing animals.

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Effects of Dietary Restriction on Growth, Neurobehavior, and Reproduction in Developing Kunmin Mice

Cited by 22 publications

References 34 publications

Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility

Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility

Mild energy restriction alters mouse–nematode transmission dynamics in free-running indoor arenas

Food restriction affects Y‐maze spatial recognition memory in developing mice

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