Effects of dietary oils on fatty acid composition and lipid peroxidation of brain membranes (myelin and synaptosomes) in rats

Salvati, Serafina; Campeggi, Lorenzo Malvezzi; Benedetti, P.; Felice, Maurizio Di; Gentile, V.; Nardini, Mirella; Tomassi, G.

doi:10.1016/0955-2863(93)90080-g

Cited by 23 publications

(14 citation statements)

References 23 publications

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“…Moreover, PAO activity was not significantly different after MeHg exposure. TBARS value increases with increased PUFA content (Salvati et al, 1993). The brain 20:4n-6 and 22:6n-3 percentages were significantly increased after MeHg exposure in both the lard and fish oil diet groups.…”

Section: Discussionmentioning

confidence: 77%

Effect of Dietary Fat on Total Mercury Content, Antioxidative Factors, and Lipid Profile in Adult Mice Exposed to Low Levels of Methylmercury

Shirai

Yamaki

Yamashita

et al. 2012

FSTR

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Section: Discussionmentioning

confidence: 77%

Effect of Dietary Fat on Total Mercury Content, Antioxidative Factors, and Lipid Profile in Adult Mice Exposed to Low Levels of Methylmercury

Shirai

Yamaki

Yamashita

et al. 2012

FSTR

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“…This suggests that dietary fish oil increases DHA at the expense of 22:5n-6 in boar semen, as has been shown for other tissues in several similar investigations. When feeding fish oil supplements, an increase of EPA was seen in platelets from rats (Galloway et al, 1985;Knapp et al, 1986) and humans (Wahle and Brown, 1990), of EPA and DHA in liver tissue and platelets from growing pigs (Lepine et al, 1993) and of n-3 PUFAs in myelin membranes from rat brains (Salvati et aL, 1993). In all these investigations, an increase in one or more n-3 PUFAs coincides with a decrease in n-6 PUFAs, mainly of arachidonic acid (20:4n-6).…”

Section: Discussionmentioning

confidence: 96%

A preliminary study on the effect of dietary supplementation with cod liver oil on the polyunsaturated fatty acid composition of boar semen

Paulenz¹,

Taugbøl²,

Hofmo³

et al. 1995

Vet Res Commun

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Eight mature Norwegian Landrace boars, of proven fertility and in routine semen production for AI, were fed individually with the same basic diet for 9 weeks. One group of 4 animals served as the control, the remaining 4 boars received a daily supplement of 75 ml cod liver oil (CLO-group). Fifteen consecutive semen samples were collected from each boar. The fatty acid composition of the semen was determined, and the content of the 15 most numerous fatty acids with a chain length longer than 12 carbon atoms was followed over time. In both groups, the proportion of 16:1n-7 decreased significantly, while 16:0 and 22:6n-3 (DHA) increased. By the end of the experiment, DHA had tended to increase and 22:5n-6 to decrease to a greater extent in the CLO-group. A significant difference between the groups was seen for one n-6 PUFA (22:4n-6), which remained unchanged in the control group but decreased in the CLO-group. No change was seen in docosapentaenoic acid (22:5n-3) and eicosapentaenoic acid (20:5n-3) was not found in any sample. These results indicate that CLO supplementation affects the fatty acid composition of boar semen. There were no significant differences in the non-return rates (4-25 days) between the two groups before, during or after the experiment.

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“…Our studies [44,45] reported that whole brain homogenates of rats fed diets supplemented with fish oil have lower levels of myelin basic protein and lower CNPase activity. These data suggest that reduced enzyme activity may be due to a delay in myelin deposition and/or instability in the myelin structure.…”

Section: Resultsmentioning

confidence: 99%

Diet, Lipids and Brain Development

Salvati¹,

Attorri²,

Avellino³

et al. 2000

Dev Neurosci

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Brain development is a sequential anatomical process characterised by specific well-defined stages of growth and maturation. One of the fundamental and necessary events in the normal development of the central nervous system in vertebrates is the formation of a myelin sheath. It is becoming more evident that this process is influenced by dietary lipids. A number of findings have indicated that the administration of a diet deficient in essential fatty acids during development causes hypomyelination in the rat brain. Our studies have shown that lipids can also play a role in accelerating myelinogenesis in the brain of rats whose mothers had been fed, during pregnancy and lactation, a lipid fraction extracted from yeast grown on n-alkanes. Further studies have shown that accelerated myelinogenesis is connected to a precocious appearance of behavioural reflexes. Thus, the use of particular lipids in human nutrition must be carefully screened for possible effects on brain development.

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Effects of dietary oils on fatty acid composition and lipid peroxidation of brain membranes (myelin and synaptosomes) in rats

Cited by 23 publications

References 23 publications

Effect of Dietary Fat on Total Mercury Content, Antioxidative Factors, and Lipid Profile in Adult Mice Exposed to Low Levels of Methylmercury

Effect of Dietary Fat on Total Mercury Content, Antioxidative Factors, and Lipid Profile in Adult Mice Exposed to Low Levels of Methylmercury

A preliminary study on the effect of dietary supplementation with cod liver oil on the polyunsaturated fatty acid composition of boar semen

Diet, Lipids and Brain Development

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