Effects of Dietary Nucleotides on Serum Antibody and Splenic Cytokine Production in Mice

Nagafuchi, Shigeo; Katayanagi, Tomoko; Nakagawa, Emiko; Takahashi, Takeshi; Yajima, Takaji; Yonekubo, Akie; Kuwata, Tamotsu

doi:10.1016/s0271-5317(97)00086-9

Cited by 37 publications

(23 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patel et al (2008) showed that injection of chicks with oligodeoxynucleotides containing CpG-ODN motifs induced an upregulation of IFN-γ and IL-12, suggesting a Th-1-like immune response. In mice fed a diet supplemented with nucleotides, increased IFN-γ production by spleen cells was observed compared with a nonsupplemented diet (Nagafuchi et al, 1997). Interleukin-10 has been described as a macrophage-inactivating regulatory cytokine that suppresses proinflammatory cytokine secretion and inhibits the expression of major histocompatibility class II and costimulatory molecules (O'Garra and Vieira, 2007).…”

Section: Discussionmentioning

confidence: 99%

Performance, histomorphology, and Toll-like receptor, chemokine, and cytokine profile locally and systemically in broiler chickens fed diets supplemented with yeast-derived macromolecules

et al. 2013

View full text Add to dashboard Cite

The turnover of intestinal epithelial cells is a dynamic process that includes adequate cell proliferation and maturation in the presence of microbiota and migration and seeding of immune cells in early gut development in chickens. We studied the effect of yeastderived macromolecules (YDM) on performance, gut health, and immune system gene expression in the intestine of broiler chickens. One thousand eighty 1-d-old birds, with 60 birds per pen and 6 pens per treatment, were randomly assigned to 3 treatment diets; a diet containing monensin (control), control diet supplemented with bacitracin methylene disalycylate (BMD), and BMD diet supplemented with YDM. Feed intake, BW, mortality, ileum histomorphology, and gene expression of Toll-like receptors (TLR2b, TLR4, and TLR21), cytokines [interferon (IFN)-γ, IFN-β, , and transforming growth factor (TGF)-β4], and cluster of differentiation (CD)40 in the ileum, cecal tonsil, bursa of Fabricius, and spleen were assessed. No significant overall difference in performance in terms of feed intake, BW gain, and G:F was observed among treatments (P > 0.05). The YDM diet resulted in significantly higher villi height and villi height:crypt depth ratio compared with BMD and control diets (P < 0.05). A significantly lower mortality was observed in the YDM treatment compared with both control and BMD treatments. Compared with the control, gene expression analysis in YDM treatment showed no major change in response in the ileum, whereas higher CD40, in the cecal tonsil; TLR2b, TLR4, TLR21, and TGF-β4 in the bursa of Fabricius; and TLR4, IL12p35, in the spleen was observed (P < 0.05). In conclusion, supplementation of YDM supports pro-and anti-inflammatory cytokine production via T helper type 1 and 2 (Th1 and Th2) cell-associated pathways both locally and systemically with a stronger additive effect in the cecal tonsil in the presence of BMD in the diet of chickens.

show abstract

Section: Discussionmentioning

confidence: 99%

Performance, histomorphology, and Toll-like receptor, chemokine, and cytokine profile locally and systemically in broiler chickens fed diets supplemented with yeast-derived macromolecules

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Various studies have focused on the effect of supplemental dietary nucleotides on the immune function in human subjects (95) and pigs (96) ; however, most studies have been performed in rodents (13) . For example, feeding nucleotide-supplemented diets to rodents has been associated with an increase in graft v. host disease mortality (97) , a rejection of allogenic grafts (98,99) and a delayed cutaneous hypersensitivity (100) .…”

Section: Immunological Effectsmentioning

confidence: 99%

The role of dietary nucleotides in single-stomached animals

2011

View full text Add to dashboard Cite

The transition from liquid to solid feed during weaning results in morphological, histological and microbial changes in the young animal's intestinal tract and often is associated with diarrhoea. The ban of in-feed antibiotics in pig production in the European Union has led to increasing interest in alternatives to overcome weaning-associated problems. Among others, nucleotides may have the potential to alleviate health impairments due to weaning. Nucleotides are natural components of the non-protein fraction of milk and have important effects on the maintenance of health in young animals. Nucleotides and their related metabolic products play key roles in many biological processes and become essential dietary components when endogenous supply is insufficient for normal function. The present review summarises nucleotide composition of milk from different species, the biology of nucleotides and possible effects of dietary nucleotides on intestinal morphology and function, intestinal microbiota, immune function, nutrient metabolism, hepatic morphology and function as well as growth performance. Special attention is given to data available for pigs, and suggestions are made for inclusion of nucleotides in the diet to benefit piglets' health and reduce the consequences accompanying early weaning.

show abstract

“…On the other hand, human colostrum contains several kinds of nucleotides (CMP, UMP, GMP and AMP) at relatively low levels between 1.0 and 23.0 μmol/l (Duchen and Thorell, 1999). These nucleic acids and their derivatives are reported to induce a large number of biological actions in the digestive system (Nunez et al, 1990;Uauy et al, 1990;Brunser et al, 1994;Bueno et al, 1994;Ortega et al, 1994), the immune system (Carver et al, 1990;Van Buren et al, 1983, 1985Kulkarni et al, 1989;Matsumoto et al, 1995;Nagafuchi et al, 1997;Rudolph et al, 1986) and the microbial flora in the gut (Gil et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Oral administration of uridylic acid increases plasma leptin, but suppresses glucose and non-esterified fatty acid concentrations in rats

et al. 2006

View full text Add to dashboard Cite

Effects of Dietary Nucleotides on Serum Antibody and Splenic Cytokine Production in Mice

Cited by 37 publications

References 17 publications

Performance, histomorphology, and Toll-like receptor, chemokine, and cytokine profile locally and systemically in broiler chickens fed diets supplemented with yeast-derived macromolecules

Performance, histomorphology, and Toll-like receptor, chemokine, and cytokine profile locally and systemically in broiler chickens fed diets supplemented with yeast-derived macromolecules

The role of dietary nucleotides in single-stomached animals

Oral administration of uridylic acid increases plasma leptin, but suppresses glucose and non-esterified fatty acid concentrations in rats

Contact Info

Product

Resources

About