Oral administration of uridylic acid increases plasma leptin, but suppresses glucose and non-esterified fatty acid concentrations in rats

Yoshioka, Koshiro; Katoh, K.; Hayashi, Hideaki; Mashiko, T.; Obara, Yoshiaki

doi:10.1016/j.lfs.2006.01.029

Cited by 2 publications

(8 citation statements)

References 27 publications

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“…1C). This result is consistent with the previous finding with rats, which showed the reduced TG content in the liver (Yoshioka et al. 2006).…”

Section: Discussionsupporting

confidence: 94%

“…The reason for this discrepancy is not clear. The difference in age, which was discussed as one of reasons to explain the different responses between calves and rats (Yoshioka et al. 2006), may be the case in the present study, because the age of the milk‐fed kids in the present study was greater than that of the milk‐fed calves.…”

Section: Discussionmentioning

confidence: 61%

“…In a previous paper with young calves, we observed the reduced postprandial plasma glucose (but not NEFA) and insulin levels and reduced perirenal fat accumulation by the UMP feeding (Katoh et al 2005). In addition, another paper from our laboratory with young but weaned rats demonstrated that UMP feeding caused a significant reduction in the basal glucose and NEFA levels, a reduction that was accompanied by a significant increase in the plasma leptin level and a slight reduction in body weight gain (Yoshioka et al 2006). These findings demonstrate that UMP feeding causes a reduction in the postprandial changes in glucose metabolism, although there apparently exists some differences, which may result from a species difference in the effects of UMP ingestion on metabolic parameters.…”

Section: Discussionmentioning

confidence: 98%

“…2005). In addition, another paper from our laboratory with young but weaned rats demonstrated that UMP feeding caused a significant reduction in the basal glucose and NEFA levels, a reduction that was accompanied by a significant increase in the plasma leptin level and a slight reduction in body weight gain (Yoshioka et al. 2006).…”

Section: Discussionmentioning

confidence: 99%

“…2005), we fed pre‐weaning calves with milk containing UMP at 2 g/day for 7 days, and demonstrated that UMP feeding suppressed perirenal fat deposition and the postprandial increase in plasma glucose and insulin. In young rats (Yoshioka et al. 2006), oral administration of UMP at 44 mg/day (equivalent for the metabolic body size) for 10 days significantly suppressed plasma levels of glucose and NEFA, but not that of insulin.…”

Section: Introductionmentioning

confidence: 99%

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Effects of 5′‐uridylic acid feeding on postprandial plasma concentrations of metabolites and metabolic hormones in pre‐weaning goats

Ohtani¹,

Kobayashi²,

Takahashi³

et al. 2009

Animal Science Journal

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5'-Uridylic acid (UMP), which is present at high concentrations in cow's colostrum, has been shown to cause a reduction in increased plasma levels of insulin and glucose after ingestion of milk replacer in pre-weaning calves. However, the precise mechanisms of UMP action have not been investigated, and its action has not been investigated in other pre-weaning ruminants. In order to demonstrate whether UMP causes changes in postprandial metabolic and hormonal parameters in pre-weaning goats, 11 Saanen kids were given milk replacer (twice a day) without (n = 5) or with (n = 6) UMP (1 g for each meal, 2 g/day for each head) for 14 days. Analysis of blood samples taken in the morning of day 14 demonstrated that the feeding of milk replacer with UMP abolished the significant changes in postprandial plasma glucose, NEFA, GH and insulin concentrations induced by feeding of milk replacer alone, and demonstrated a tendency to increase IGF-I levels. However, there was no significant difference between the two groups at any sampling time. We conclude that UMP feeding with milk replacer showed a tendency to blunt the postprandial changes in levels of some plasma metabolites and hormones that are induced by replacer alone in pre-weaning goats.

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“…1C). This result is consistent with the previous finding with rats, which showed the reduced TG content in the liver (Yoshioka et al. 2006).…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of 5′‐uridylic acid feeding on postprandial plasma concentrations of metabolites and metabolic hormones in pre‐weaning goats

Ohtani¹,

Kobayashi²,

Takahashi³

et al. 2009

Animal Science Journal

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Maternal supplementation with uridine influences fatty acid and amino acid constituents of offspring in a sow–piglet model

et al. 2020

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Nucleotide plays an important role in the regulation of cellular energy and protein homeostasis. The objective of the current study was to investigate the cumulative effects of maternal supplementation with nucleotides in the form of uridine (UR) on fatty acids and amino acids constituents of neonatal piglets. A total of 52 pregnant sows with similar parity were assigned randomly and equally into the control (CON) group (fed a basal diet) or UR group (fed a basal diet with 150g/t UR). The experiment started on d 85 of gestation and ended on the day of delivery. The reproductive performance was recorded, and placenta, blood and liver samples of neonatal piglets were collected before consuming colostrum during farrowing. Results showed that supplementing with UR in sow’ diet significantly decreased the birth mortality of pigs (P = 0.05). In addition, maternal dietary UR supplementation increased serum total cholesterol (CHOL), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) of neonatal piglets (P < 0.05). Moreover, the amino acid profile of serum and liver of neonatal piglets was affected by the addition of UR in sows’ diets (P<0.05). Furthermore, an up-regulation of mRNA expression of energy metabolism-related genes, including fatty acid elongase 5 (ELOVL5), fatty acid desaturase 1 (FADS1), hormone-sensitive lipase (HSL) and cholesterol- 7a-hydroxylase (CYP7a1), was observed in the liver of neonates from the UR group. Additionally, a decrease in placental gene expression of excitatory amino acid transporters 2 (EAAT2), excitatory amino acid transporters 3 (EAAT3), neutral AA transporter 1(LAT1) in UR group was concurrently observed (P<0.05), and higher protein expression of phosphorylated protein kinase B (P-AKT), raptor, peroxisome proliferator activated receptor α (PPARα) and PPARγ in placenta from UR group was also observed, (P<0.05). Together, these results showed that maternal UR supplementation could regulate the nutrients transport of placenta, largely in response to an alteration of mTORC1-PPARs signaling, thus regulating the nutrition metabolism of neonatal piglets, and improving reproductive performance.

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Oral administration of uridylic acid increases plasma leptin, but suppresses glucose and non-esterified fatty acid concentrations in rats

Cited by 2 publications

References 27 publications

Effects of 5′‐uridylic acid feeding on postprandial plasma concentrations of metabolites and metabolic hormones in pre‐weaning goats

Effects of 5′‐uridylic acid feeding on postprandial plasma concentrations of metabolites and metabolic hormones in pre‐weaning goats

Maternal supplementation with uridine influences fatty acid and amino acid constituents of offspring in a sow–piglet model

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