Effects of dietary nucleoside-nucleotide mixture on memory in aged and young memory deficient mice

Chen, Tzu-Hsiu; Huang, Hsiu-Ping; Matsumoto, Yōko; Wu, Shie-Hwa; Wang, Mingfu; Chung, Shu-Ying; Uezu, Kayoko; Moriyama, Tomoe; Uezu, Eiko; Korin, Tomoo; Sato, Seiji; Yamamoto, Shigeru

doi:10.1016/0024-3205(96)00526-7

Cited by 15 publications

(1 citation statement)

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“…Increases in neuroprotective Ino and Urd levels with age in the human brain cortex and white matter [63] could compensate for the cytotoxic effect of increased concentrations of Ado to some extent [24,[277][278][279]. It has been shown that a nucleotide-nucleoside mixture (Ino, GMP, Cyd, Urd and Thd) as a food additive reduces ageing and memory problems [199,280], suggesting that endogenous nucleoside metabolism might contribute to senile dementia and depression [197,280].…”

Section: Age-dependent Changes In Nucleoside Metabolic Enzyme Activitmentioning

confidence: 96%

Area, Age and Gender Dependence of the Nucleoside System in the Brain: a Review of Current Literature

Kovács

Juhász

Palkovits

et al. 2011

CTMC

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Nucleosides, such as uridine, inosine, guanosine and adenosine, may participate in the regulation of sleep, cognition, memory and nociception, the suppression of seizures, and have also been suggested to play a role in the pathophysiology of some neurodegenerative and neuropsychiatric diseases. Under pathological conditions, levels of nucleosides change extremely in the brain, indicating their participation in the pathophysiology of disorders like Alzheimer's disease, Parkinson's disease and schizophrenia. These findings have resulted in an increasing attention to the roles of nucleosides in the central nervous system. The specific effects of nucleosides depend on the expression of their receptors and transporters in neuronal and glial cells, as well as their extracellular concentrations in the brain. A complex interlinked metabolic network and transporters of nucleosides may balance nucleoside levels in the brain tissue under normal conditions and enable the fine modulation of neuronal and glial processes via nucleoside receptor signaling mechanisms. Brain levels of nucleosides were found to vary when measured in a variety of different brain regions. In addition, nucleoside levels also depend on age and gender. Furthermore, distributions of nucleoside transporters and receptors as well as nucleoside metabolic enzyme activities demonstrate the area, age and gender dependence of the nucleoside system, suggesting different roles of nucleosides in functionally different brain areas. The aim of this review article is to summarize our present knowledge of the area-, age- and gender-dependent distribution of nucleoside levels, nucleoside metabolic enzyme activity, nucleoside receptors and nucleoside transporters in the brain.

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