Effects of dietary methylmercury on liver and kidney histology in the neotropical fish Hoplias malabaricus

Prodocimo, Maritana Mela; Randi, Marco Antônio Ferreira; Ventura, Dora Fix; Carvalho, Carlos Eduardo Veiga de; Pelletier, Émilien; Ribeiro, Ciro Alberto de Oliveira

doi:10.1016/j.ecoenv.2006.11.013

Cited by 220 publications

(130 citation statements)

References 44 publications

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“…Moreover, MMCs contained melanin which is well known for its ability to neutralize free radicals and cations associated with heavy metals (Robert and Ellis 1978;Agius 1985). Therefore, the high density of MMCs in spleen could possibly be used as a potent biomarker for Hg contamination in fish (Mela et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Short-term Exposure of Nile Tilapia (Oreochromis niloticus) to Mercury

et al. 2012

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To investigate effects of short-term mercury (Hg) exposure in tilapia (Oreochromis niloticus) including histopathological changes, Hg bioaccumulation, and protective role of metallothionein (MT) in different exposure routes, adult tilapias were intraperitoneally injected, orally intubated, or semistatically exposed to 0.5, 1, 2, 5 mg/g mercuric chloride. Histopathology, autometallography (AMG), inductive coupled plasma-atomic emission spectrometry (ICP-AES), and MT immunohistochemistry were determined at 0, 3, 6, 9, 12, and 15 days postexposure. Microscopic lesions were observed in the kidney, hepatopancreas, spleen, and intestine. AMG positive grains were found in renal tubule epithelium, melanomacrophage centers (MMCs), and intestinal epithelium of treated tilapias. Hg concentrations measured by ICP-AES in abdominal visceral organs were significantly higher than in other organs. All exposure routes caused lesions of increasing severity and Hg accumulations in a dose-dependent manner. Semistatic groups produced the highest intensity of lesions, AMG positive staining, as well as total Hg concentrations. Positive MT expression in renal tubule epithelium, pancreatic acini, and splenic MMCs was observed only in semistatic groups. The semistatic exposure route demonstrated the most significant microscopic lesions, Hg bioaccumulation, and MT expression.

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Section: Discussionmentioning

confidence: 99%

Short-term Exposure of Nile Tilapia (Oreochromis niloticus) to Mercury

et al. 2012

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“…Moreover, the majority of available literature, though sporadically addressing other tissues, concerns laboratory approaches. 11,12 The significance of fish laboratory exposures is often compromised by the use of environmentally unrealistic concentrations, as well as by artificial modes of exposure such as a single exposure route. Additionally, previous field studies didn't take into account an extensive range of tissues, and their main purpose was to assess the human risk through fish consumption.…”

Section: Introductionmentioning

confidence: 99%

Mercury distribution in key tissues of fish (Liza aurata) inhabiting a contaminated estuary—implications for human and ecosystem health risk assessment

et al. 2009

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This study brings a new viewpoint based on multiple-tissue analyses to form the basis for a predictive mode of mercury accumulation dynamics in fish body under field conditions. Total mercury (T-Hg) was determined in key tissues of Liza aurata captured along an estuarine contamination gradient, displaying the following hierarchy: kidney > liver > muscle > brain > gills > blood. Brain was the tissue that better reflected the mercury contamination extent, closely followed by liver and muscle. Organic mercury (O-Hg) measured in muscle and liver represented more than 85% and less than 30% of the T-Hg, respectively. The lowest O-Hg percentage was found in the most contaminated area, for both muscle and liver. Mercury distribution and accumulation patterns showed dependence on the specific tissue. The high mercury levels found in organs involved in vital physiological processes point out the risk to autochthonous fish fauna. Human risk associated to the ingestion of fish living in the surveyed areas cannot be excluded.

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“…Methyl mercury is the dominant form of Hg found in whole wild fish [1], and through the process of biomagnification can accumulate in their tissues to concentrations that may adversely affect various aspects of their physiology and behavior. In the laboratory, the chronic dietary exposure of fish to MeHg has resulted in decreased growth [2], reduced swimming activity [3], and tissue damage in the liver and kidney (necrotic areas and increased macrophage aggregates) [4], as well as changes at the molecular level including gene expression [5] and decreased antioxidant enzyme activity [3].…”

Section: Introductionmentioning

confidence: 99%

Evidence of impaired health in yellow perch (Perca flavescens) from a biological mercury hotspot in northeastern north America

Batchelar

Kidd

Drevnick

et al. 2013

Enviro Toxic and Chemistry

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Abstract-Few studies have investigated the effects of mercury (Hg) on wild fish from remote areas, even though these fish can have high total Hg concentrations. In Kejimkujik National Park and National Historic Site (KNPNHS), Nova Scotia, Canada, concentrations of total Hg in many yellow perch (Perca flavescens) currently exceed the estimated threshold level for adverse effects in fish (0.2 mg Hg g À1 (wet wt), whole body). To determine whether Hg exposure is adversely affecting the general health of these fish, the authors collected male and female perch in the fall of 2009 and 2010 from 12 lakes within KNPNHS. The health endpoints condition, liver somatic index (LSI), and macrophage aggregates (MAs; indicators of oxidative stress and tissue damage) in the liver, kidney, and spleen were examined, and in female perch were compared between lakes and related to Hg concentrations measured in the muscle and liver tissue. No negative relationships between fish condition or LSI and Hg were found. However, within the liver, kidney, and spleen tissues of females, the relative area occupied by MAs was positively related to both muscle and liver Hg concentrations, indicating the health of these perch was adversely affected at the cellular level. These findings raise concerns for the health of these perch as well as for other wild fish populations known to have similarly elevated Hg concentrations. Environ. Toxicol. Chem. 2013;32:627-637. # 2012 SETAC

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Effects of dietary methylmercury on liver and kidney histology in the neotropical fish Hoplias malabaricus

Cited by 220 publications

References 44 publications

Short-term Exposure of Nile Tilapia (Oreochromis niloticus) to Mercury

Short-term Exposure of Nile Tilapia (Oreochromis niloticus) to Mercury

Mercury distribution in key tissues of fish (Liza aurata) inhabiting a contaminated estuary—implications for human and ecosystem health risk assessment

Evidence of impaired health in yellow perch (Perca flavescens) from a biological mercury hotspot in northeastern north America

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