Effects of dietary lycopene supplementation on intestinal morphology, antioxidant capability and inflammatory response in finishing pigs

Liu, Aimin; Chen, Xiaoling; Huang, Zhiqing; Chen, Shuai; Yu, Bing; Chen, Hong; He, Jun; Yan, Hui; Zheng, Ping; Yu, Jingquan; Luo, Yuheng

doi:10.1080/10495398.2021.2009490

Cited by 12 publications

(7 citation statements)

References 37 publications

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“…The supplementation of LY, CAR, and LC did not alter the VH, CD, and VCR in the ileum ( p < 0.05). In contrast, our results agreed with a previous study and showed significance in VCR and VH of jejunum and duodenum but not in ileum when using Lycopene alone [ 60 ]. While the present study showed a significant increase in the jejunum and duodenum VH, CD, and VCR.…”

Section: Resultssupporting

confidence: 92%

“…They work by blocking the para-cellular space between epithelial cells, which prevents the diffusion of gut bacteria and other antigens across the epithelium [ 91 ]. Previous research has shown that the use of Lycopene alone can increase the expression of CLDN1 but does not affect the expression of OCLN and ZO-1 [ 60 ]. On the other hand, L-Carnitine supplementation alone can increase the expression of ZO-1 [ 92 ].…”

Section: Discussionmentioning

confidence: 99%

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The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters

Ennab

et al. 2023

Animals

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The objective of this study was to investigate the impact of Lycopene and L-Carnitine, individually or in combination, on various physiological and molecular factors related to intestinal health and absorption ability in Roosters, such as intestinal morphology, serum biochemical parameters, genes involved in Lycopene uptake, nutritional transport genes, and tight junction genes. The findings of the study revealed that the combination of L-Carnitine and Lycopene supplementation had been found to increase the serum concentration levels of TP and ALB. Interestingly, the relative mRNA expression of genes responsible for Lycopene uptakes, such as SR-BI and BCO2, was higher in the LC group compared to other groups. Additionally, the expression of specific nutritional transport genes in the duodenum was significantly affected by both CAR and LC supplementation groups. The tight junction gene OCLN showed a significant increase in expression in the combination group compared to using either Lycopene or L-Carnitine alone. This study concludes that using Lycopene and L-carnitine in combination in poultry feed can potentially improve intestinal morphology and serum biochemical parameters, increase Lycopene bioavailability, improve nutrients uptake, and enhance the integrity of duodenal tight junctions in Roosters.

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Section: Resultssupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters

Ennab

et al. 2023

Animals

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“…19 It has also been reported that LYC (200 mg per kg bodyweight, given orally) exerted a protective effect by increasing the villus height/crypt depth ratio in the jejuna of Duroc × Landrace × Yorkshire barrows. 33 In the present study, the protective activity of LYC involved the suppression of villus injury in the jejunum and increased the villus height/crypt depth ratio, and TJ protein expression. These results indicate that ZEN + DON + AFB1-induced jejunal injury is inhibited by LYC, which improves the jejunal morphology and enhances the TJ function in mice.…”

Section: Papersupporting

confidence: 48%

Lycopene alleviates multiple-mycotoxin-induced toxicity by inhibiting mitochondrial damage and ferroptosis in the mouse jejunum

et al. 2022

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“…Lycopene could be an effective pharmacological therapy for treating liver damage induced by long-term CS treatment (Rocha et al 2021). In finishing pigs, dietary lycopene supplementation improved intestinal shape, and tight junction function inhibited inflammatory response and increased antioxidant capacity (Liu et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)

et al. 2022

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Lycopene is a group of phytochemicals found in nature, primarily in fruits and vegetables. Lycopene is thought to protect against a variety of diseases attributed to its antioxidant capabilities. Lycopene has anti-inflammatory, anti-cancer, and immunity-boosting qualities, among other biological and pharmacological benefits. COVID-19 (coronavirus disease 19) is an infectious disease caused by the SARS-CoV-2 virus, which has recently emerged as one of the world's leading causes of death. Patients may be asymptomatic or show signs of respiratory, cytokine release syndrome, gastrointestinal, or even multiple organ failure, all of which can lead to death. In COVID-19, inflammation, and cytokine storm are the key pathogenic mechanisms, according to SARS-CoV-2 infection symptoms. ARDS develops in some vulnerable hosts, which is accompanied by an inflammatory "cytokine syndrome" that causes lung damage. Immunological and inflammatory markers were linked to disease severity in mild and severe COVID-19 cases, implying that inflammatory markers, including IL-6, CRP, ESR, and PCT were significantly linked with COVID-19 severity. Patients with severe illness have reduced levels of several immune subsets, including CD4 + T, NK, and CD8 + cells. As a result, lycopene can be commended for bolstering physiological defenses against COVID-19 infections

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Effects of dietary lycopene supplementation on intestinal morphology, antioxidant capability and inflammatory response in finishing pigs

Cited by 12 publications

References 37 publications

The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters

The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters

Lycopene alleviates multiple-mycotoxin-induced toxicity by inhibiting mitochondrial damage and ferroptosis in the mouse jejunum

Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)

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