The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters

Ennab, Wael; Ye, Nanwei; Wu, Haoze; Ullah, Saif; Hadi, Tavakolikazerooni; Bassey, Anthony Pius; Mustafa, Sheeraz; Jiang, Jingle; Wei, Quanwei; Shi, Fangxiong

doi:10.3390/ani13081274

Cited by 6 publications

(4 citation statements)

References 82 publications

(103 reference statements)

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“…For fixed tissues, hematoxylin and eosin staining was performed ( 34 ) followed by microscopic observation and image processing and analysis system (Version 1, Leica Imaging Systems Ltd, Cambridge, UK). Villus height (VH, μm), crypt depth (CD, μm), and villus width (VW, μm) measurements were performed from 3 different regions of each section (with intact villi and straight orientation), and the average values were taken as the measurement results ( 35 ).…”

Section: Methodsmentioning

confidence: 99%

Zinc intake ameliorates intestinal morphology and oxidative stress of broiler chickens under heat stress

Hu,

Li,

Peng

et al. 2024

Front. Immunol.

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Zinc (Zn), an essential trace element for poultry, plays a crucial role in promoting growth, improving feed conversion efficiency, enhancing antioxidant activity, and preventing disease. This study investigated the impact of different levels and sources of dietary Zn supplementation on the growth performance, intestinal morphology and antioxidant activity of broiler chickens under heat stress conditions. In this experiment, 1024 Xueshan chickens were divided into eight groups and subjected to heat stress conditions with different levels of Zn supplementation (30 mg/kg, 60 mg/kg, and 90 mg/kg) using organic or inorganic sources. Our findings indicated that dietary Zn supplementation significantly increased the feed-to-weight ratio of broilers during the experimental period under heat stress. Moreover, Zn supplementation positively increased the villus height and villus width in the jejunum and ileum at 74 and 88 days old, with the 60 and 90 mg/kg groups outperforming other groups, and organic Zn was more effective than inorganic Zn. Furthermore, Zn supplementation significantly increased serum antioxidant levels, with higher superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-px) activities, and organic Zn was more effective than inorganic Zn. This study concludes that Zn supplementation is beneficial in mitigating the detrimental impacts of heat stress on broilers. The findings suggest that employing Zn as a strategy can enhance productivity in the poultry industry by positively influencing intestinal morphology and bolstering antioxidant activity to counteract potential stress.

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Section: Methodsmentioning

confidence: 99%

Zinc intake ameliorates intestinal morphology and oxidative stress of broiler chickens under heat stress

Hu,

Li,

Peng

et al. 2024

Front. Immunol.

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“…The pharmacological effects of natural metabolites have drawn an enormous amount more attention in recent years ( Pan et al, 2019 ). Clinical data and in vitro studies have shown the beneficial effects of natural products on a wide range of diseases ( Ennab et al, 2019 ; Mustafa et al, 2019 ; Ullah et al, 2020 ; Ennab et al, 2023 ). These changes in the gut microbiota caused by natural substances demonstrate that natural products have a preventive effect on the development of inflammation into cancer.…”

Section: Effect Of Natural Products On Gut-x Axis (Pharmacology Toxic...mentioning

confidence: 99%

Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases

Li,

Wang,

et al. 2024

Front. Pharmacol.

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Introduction: The gastrointestinal tract is integral to defending against external contaminants, featuring a complex array of immunological, physical, chemical, and microbial barriers. Mycotoxins, which are toxic metabolites from fungi, are pervasive in both animal feed and human food, presenting substantial health risks.Methods: This review examines the pharmacological, toxicological, and microbiological impacts of natural products on mycotoxicosis, with a particular focus on the gut-x axis. The analysis synthesizes current understanding and explores the role of natural products rich in polysaccharides, polyphenols, flavonoids, and saponins. Results: The review highlights that mycotoxins can disrupt intestinal integrity, alter inflammatory responses, damage the mucus layer, and disturb the bacterial balance. The toxins' effects are extensive, potentially harming the immune system, liver, kidneys, and skin, and are associated with serious conditions such as cancer, hormonal changes, genetic mutations, bleeding, birth defects, and neurological issues. Natural products have shown potential anticancer, anti-tumor, antioxidant, immunomodulatory, and antitoxic properties.Discussion: The review underscores the emerging therapeutic strategy of targeting gut microbial modulation. It identifies knowledge gaps and suggests future research directions to deepen our understanding of natural products' role in gut-x axis health and to mitigate the global health impact of mycotoxin-induced diseases.

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“…Histological analysis was carried out in accordance with previous research [43][44][45][46][47]. The tissues were first dehydrated using a graded series of ethanol and xylene, followed by paraffin wax clearing and infiltration.…”

Section: Histologic Assessmentmentioning

confidence: 99%

Impact of Cadmium and Lead Exposure on Camel Testicular Function: Environmental Contamination and Reproductive Health

Ullah

Ennab

Wei

et al. 2023

Animals

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The free grazing habits of camels from various sources may cause heavy metals to bioaccumulate in their tissues and organs, possibly resulting in higher amounts of these toxic substances in their bodies over time. The aim of this study was to assess the exposure impact of lead (Pb) and cadmium (Cd) on bull camels of the Lassi breed, aged 7 to 8 years, at a site near the industrial area and another two non-industrial sites, to analyze the presence of heavy metals. Samples from three sites were collected from thirty camels (n = 10/each), soil and water (n = 30), and five different plants (n = 15/each) for analysis. Testes were collected for atomic absorption spectrometry (AAS), and hematoxylin-eosin (HE) staining. Serum samples were obtained to measure testosterone levels by radioimmunoassay (RIA). Samples were obtained from plants, soil, water, blood, serum and urine for AAS. According to the results, the testes’ weight, length, width, and volume significantly decreased at the industrial site compared with the other two sites as a result of exposure to Cd and Pb. Additionally, blood testosterone concentrations were considerably lower at the industrial site, indicating a detrimental impact on testicular steroidogenesis. The histological investigation of the industrial site indicated structural disturbances, including seminiferous tubule degeneration and shedding, cellular debris in seminiferous tubules, lining epithelium depletion, and vacuolation. Elevated amounts of Cd and Pb were found at the industrial site when analyzed using water, soil, plants, testes, serum, and urine. These findings demonstrate the adverse effects of Pb and Cd exposure on camel testicular function, including decreased weight and altered steroidogenesis. These findings are essential for understanding the impact of exposure to Pb and Cd on camel reproductive function and for developing successful prevention and management plans for these exposures in this species.

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The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters

Cited by 6 publications

References 82 publications

Zinc intake ameliorates intestinal morphology and oxidative stress of broiler chickens under heat stress

Zinc intake ameliorates intestinal morphology and oxidative stress of broiler chickens under heat stress

Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases

Impact of Cadmium and Lead Exposure on Camel Testicular Function: Environmental Contamination and Reproductive Health

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