Effects of dietary grape pomace flour on the purinergic signaling and inflammatory response of grass carp experimentally infected with Pseudomonas aeruginosa

Baldissera, Matheus D.; Souza, Carine F.; Descovi, Sharine N.; Verdi, Camila Marina; Zeppenfeld, Carla C.; Silva, Lenise de Lima; Gindri, Amanda Leitão; Cunha, Mauro Alves da; Santos, Roberto C.V.; Baldisserotto, Bernardo; Silva, Aleksandro S. Da

doi:10.1016/j.aquaculture.2019.01.015

Cited by 16 publications

(9 citation statements)

References 48 publications

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“…In another experiment on rainbow trout, only juveniles fed the highest doses of grape seed improved the nal weight 33 . On contrary, in grass carp, the supplementation was unable to show any effect on growth 34 . Therefore, antioxidants supplementation may present different outputs depending on the compound dose and the species.…”

Section: Discussionmentioning

confidence: 74%

“…Juveniles of rainbow trout fed with grape seed oil supplementation, at higher concentrations, also showed an improvement in the growth and a decreased activity of some antioxidant defenses (SOD, CAT and GST) 33 . Moreover, the use of grape pomace our, in juveniles of grass carp, did not signi cantly affect serum and splenic CAT and SOD activities when compared to the control group 34 . In contrast, a reduction of oxidative damage of lipids (LPO) was observed in rainbow trout fed with grape seed extracts supplementation, whilst the TAC content was unaltered however, con rming our present observations in sole.…”

Section: Discussionmentioning

confidence: 77%

“…Tilapia fed diets with different doses of resveratrol were able to counteract some negative effects of intraperitoneal injection of H 2 O 2 in the oxidative status of the sh, by decreasing LPO and enhancing CAT activity and TAC content [66]. Juveniles of grass carp infected with pseudmonas aeruginosa and fed grape pomace our supplementation had an increased CAT activity in serum and splenic tissues 34 .…”

Section: Discussionmentioning

confidence: 99%

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Dietary Natural Plant Extracts Modulate Growth Performance and Antioxidant Status of Senegalese Sole Postlarvae

Xavier

Conceição

Valente

et al. 2020

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Oxidative stress has a direct impact on fish production, affecting both growth and health status. Plant based extracts, such as those from green tea, curcumin and grape seeds, are known for their abundant content and diversity of polyphenols. These bioactive compounds have a high antioxidant capacity making such extracts good additives to include in fish diets potentially improving the oxidative status of fish, and therefore enhancing growth and stress resistance of farmed fish. A growth trial with Senegalese sole postlarvae (45 DAH) fed with four experimental diets, a control (CTRL) and three supplemented with natural antioxidants, namely curcumin (CC), green tea (GT) and grape seed (GS) extracts, was performed during 25 days to check if these supplements could improve growth performance and fish oxidative status. Moreover, a thermal stress was applied at the end of the growth trial, to assess the effect of these supplemented diets in stress resistance of sole juveniles.Sole growth was improved by the dietary inclusion of CC and GS compared to CTRL. Juveniles from CC and CTRL present the lowest values of oxidative damage (lipid peroxidation (LPO) and protein carbonylation (PC)). Moreover, the fish fed CC showed a decrease in stress related biomarkers (heat shock protein 70 (HSP70) and glutathione-S-transferase (GST)) compare to CTRL, which might be due to direct antioxidant capacity. In contrast the supplementation of GT and GS increased the content of oxidative damage in sole reared in standard conditions. However, after a thermal stress exposure both GT and GS treatment seem to prevent the increase of PC and decrease of antioxidant glutathione (GSH) in sole and depending on the time of exposure. In conclusion, dietary supplementation with these natural extracts modulates oxidative status and stress response after a short/long term temperature increase. The incorporation of curcumin seems to be a safe additive to include in sole diets, enhancing growth and oxidative status. The supplementation of the studied doses of green tea and grape seed extracts in fish diets needs further research as they may act as pro-oxidant depending of the culture conditions.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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Dietary Natural Plant Extracts Modulate Growth Performance and Antioxidant Status of Senegalese Sole Postlarvae

Xavier

Conceição

Valente

et al. 2020

Preprint

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“…Similarly, previous reports corroborate our study and evidencing the protective effect of grape extracts (or grape related) on oxidative induced stress. In case of abalone fed a grape seed extract supplementation diet under a thermal stress (increase of water temperature) the expression of cat was up-regulated compared to control treatment and in juveniles of grass carp infected with pseudmonas aeruginosa and fed grape pomace our supplementation had an increased CAT activity in serum and splenic tissues (51). Moreover, tilapia fed diets with different doses of resveratrol were able to counteract some negative effects of intraperitoneal injection of H 2 O 2 in the oxidative status of the sh, by decreasing the levels of LPO and enhancing CAT activity and TAC (68).…”

Section: Discussionmentioning

confidence: 89%

“…In another experiment on rainbow trout, only juveniles fed the highest doses of grape seed improved the nal weight (50). On contrary, in grass carp, the supplementation was unable to show any effect on growth (51). Therefore, antioxidants supplementation may present different outputs depending on the compound dose and the species.…”

Section: Discussionmentioning

confidence: 92%

Dietary Natural Plant Extracts Modulate Growth Performance and Antioxidant Status of Senegalese Sole Postlarvae

Xavier

Conceição

Valente

et al. 2021

Preprint

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Background Oxidative stress has a direct impact on fish production, affecting both growth and health status. Plant based extracts, such as those from green tea, curcumin and grape seeds, are known for their abundant content and diversity of polyphenols. These bioactive compounds have a high antioxidant capacity making such extracts good additives to include in fish diets potentially improving the oxidative status of fish, and therefore enhancing growth and stress resistance of farmed fish.A growth trial with Senegalese sole postlarvae (45 days after hatching) fed with four experimental diets, a control (CTRL) and three supplemented with natural antioxidants, namely curcumin (CC), green tea (GT) and grape seed (GS) extracts, was performed during 25 days to check if these supplements could improve growth performance and fish oxidative status. Moreover, a thermal stress was applied at the end of the growth trial, to assess the effect of these supplemented diets in stress resistance of sole postlarvae.ResultsSole growth was improved by the dietary inclusion of CC and GS compared to CTRL. Postlarvae from CC and CTRL present the lowest values of oxidative damage (lipid peroxidation and protein carbonylation). Moreover, the fish fed CC showed a decrease in stress related biomarkers (heat shock protein 70 and glutathione-S-transferase) compare to CTRL, which might be due to direct antioxidant capacity. In contrast the supplementation of GT and GS increased the content of oxidative damage in sole reared in standard conditions. However, after a thermal stress exposure both GT and GS treatment seem to prevent the increase of protein carbonylation content and the decrease in the levels of antioxidant glutathione in sole, depending on the time of exposure. ConclusionsOverall, dietary supplementation with these natural extracts modulates oxidative status and stress response after a short/long term temperature increase. The incorporation of curcumin seems to be a safe additive to include in sole diets, enhancing growth and oxidative status. The supplementation of the studied doses of green tea and grape seed extracts in fish diets needs further research as they may act as pro-oxidant depending of the culture conditions.

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Grape pomace flour ameliorates Pseudomonas aeruginosa-induced bioenergetic dysfunction in gills of grass carp

et al. 2019

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Effects of dietary grape pomace flour on the purinergic signaling and inflammatory response of grass carp experimentally infected with Pseudomonas aeruginosa

Cited by 16 publications

References 48 publications

Dietary Natural Plant Extracts Modulate Growth Performance and Antioxidant Status of Senegalese Sole Postlarvae

Dietary Natural Plant Extracts Modulate Growth Performance and Antioxidant Status of Senegalese Sole Postlarvae

Dietary Natural Plant Extracts Modulate Growth Performance and Antioxidant Status of Senegalese Sole Postlarvae

Grape pomace flour ameliorates Pseudomonas aeruginosa-induced bioenergetic dysfunction in gills of grass carp

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