Effects of dietary chromium supplementation on glucose tolerance and primary antibody response against peste des petits ruminants in dwarf Bengal goats (Capra hircus)

Abstract

An experiment was conducted to exploit the immune-modulation effect of trivalent chromium (Cr) for augmenting immunity against peste des petits ruminants (PPR) in dwarf black Bengal goats (Capra hircus). The goats (n 5 6 per treatment group) either received a basal diet devoid of supplemental Cr (control) or were supplemented with 0.5 mg Cr as chromic chloride (1Cr) for 60 days. Live weight gain and feed conversion efficiency improved (P , 0.05) in the 1Cr dietary group. Supplemental Cr did not affect the total number of monocytes, eosinophils and basophils (P . 0.1) although total leukocytes increased (P , 0.05) and the ratio of neutrophils to lymphocytes narrowed down (P , 0.05) in the 1Cr dietary group. The effect of Cr supplementation on variables of the intravenous glucose tolerance test (IVGTT) was inconclusive. Compared to the control group, the basal concentration of glucose (P , 0.05) and insulin (P , 0.001) was higher, clearance rate was slower (P , 0.05) and serum half-life was greater (P , 0.05) in the 1Cr dietary group during the IVGTT. Over the duration of the experiment, serum concentration of insulin increased (P , 0.001) and that of cortisol decreased (P , 0.01) in the 1Cr group, which also showed a relatively higher primary antibody (Ab) response against PPR on days 10 (P , 0.01) and 20 (P , 0.05) post-vaccination. In conclusion, the experiment indicated that supplementation of Cr as CrCl 3 , in the diet of non-stressed goats, may improve primary Ab response against PPR and help confer an augmented immunity to the disease besides promoting growth and feed conversion.

Reference Genes Selection for Quantitative Real-Time PCR Using RankAggreg Method in Different Tissues of Capra hircus

“…Trivalent chromium has been known as an essential element for normal metabolism of proteins, lipids, carbohydrates, and nucleic acids in human and husbandry animals such as cows, sheep, and goats[ 21 , 22 ]. A large body of evidence has also confirmed the positive effects of chromium on various biological properties of domestic animals including immunity against viral diseases [ 23 ], live body weight, daily weight gain, dressing percentage, longissimus muscle area, nutrient digestibility, etc. [ 21 , 22 , 24 , 25 ].…”

Effects of Dietary Chromium Methionine on Growth Performance, Carcass Composition, Meat Colour and Expression of the Colour-related Gene Myoglobin of Growing-finishing Pigs

“…Trivalent Cr plays important roles in human diet and medicine, e.g. regulating glucose and lipid metabolism in humans and laboratory animals (Mertz, 1993; Haldar et al, 2009; Krzysik et al, 2011). A recent study also reported that maternal Cr restriction significantly decreased the percent of lean body mass and fat-free mass in rat offspring (Padmavathi et al, 2010).…”

Effects of dietary chromium-yeast level on growth performance, blood metabolites, meat traits and muscle fatty acids profile, and microminerals content in liver and bone of lambs

“…Growth hormone (GH) and insulin growth factor (IGF) are involved in the metabolism of Cr (Mowat 1997); however in ruminants, Cr has little impact on growth (Kegley et al 1997;Haldar et al 2007), despite it improves the capacity response of the immune system (Haldar et al 2009); in poultry and pigs, Cr supplementation has better positive effects on metabolic response, distribution of nutrients and carcase characteristics, maybe due to an increased sensitivity to insulin and efficiency in the use of glucose (Brockman and Laarveld 1986). The magnitude of these effects depends on the chemical form, concentration and dietary contribution of Cr (Galip 2006;Yan et al 2008;Dom ınguez-Vara et al 2009;Arvizu et al 2011).…”