Effects of dietary Chinese yam polysaccharide copper complex on growth performance, immunity, and antioxidant capacity of broilers

Zhang, Jinzhou; Jin, Yan; Cao, Mengmeng; Deng, Jiahua; Chang, Yadi; Shi, Mingyu; Miao, Zhiguo

doi:10.3389/fvets.2023.1123002

Cited by 7 publications

(4 citation statements)

References 39 publications

(38 reference statements)

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“…In recent years, increasing numbers of studies have shown that polysaccharide metal complexes display diverse biological activities, such as improving growth, antioxidation, immune regulation, and antibacterial activity. Zhang et al ( Zhang J et al, 2023 ) reported that the supplementation of dietary Chinese yam polysaccharide-Cu complex could improve the indexes of the growth, carcass, serum biochemistry, immunity and oxidation resistance in broilers, such as average daily gain, the slaughter percentage, breast muscle percentage, leg muscle percentage, growth-related hormones insulin-like growth factor I, triiodothyronine, thyroxine, growth hormone, insulin, antibodies and the cytokines, IgM, IgG, IgA, IL-2, IL-4, IL-6, T-SOD, T-AOC, GSH-Px, and GSH-ST. Research showed that soybean polysaccharide iron complex can promote the growth of the beneficial bacteria Bacillus licheniformisand inhibit the proliferation of the pathogenic bacteria Staphylococcus aureus , thus improving the growth and immunity of the body ( Gao W et al, 2020 ). Due to their safety, growth-promoting effect, and immune-enhancing properties are used as functional feed additives in animal production.…”

Section: Discussionmentioning

confidence: 99%

“…As a complex carbohydrate, polysaccharide has the ability to chelate metal ions, thereby improving the bioavailability of metal ions and helping to maintain the normal physiological function of the body. Notably, polysaccharide-Cu 2+ chelates have demonstrated the potential to improve animal growth performance and exhibit significant intestinal immune-boosting functions ( Zhang J et al, 2023 ). Various studies have highlighted the antioxidant and multifunctional iron supplement potential of polysaccharide metal chelates, including dioscorea polysaccharide iron chelate (DTP-Fe), which can enhance the scavenging of DPPH free radicals ( Liu Y et al, 2023 ), ABTS+ and hydroxyl free radicals in the organism, with the antioxidant capacity of TDP-Fe increasing with higher concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and activity study of Ruoqiang jujube polysaccharide copper chelate

Moheteer,

Li,

Abulikemu

et al. 2024

Front. Pharmacol.

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Background: Polysaccharide metal chelate exhibit both immunoregulatory activity and metal element supplementation effects.Methods: In this study, Ruoqiang jujube polysaccharide copper chelate (RJP-Cu) was prepared and the preparation conditions were optimized using the response surface method. Subsequently, RJP-Cu was administered to lambs to evaluate its impact on growth performance, copper ion (Cu2+) supplementation, immune enhancement, and intestinal flora was evaluated.Results: The results indicated that optimal RJP-Cu chelation conditions included a sodium citrate content of 0.5 g, a reaction temperature of 50°C, and a solution pH of 8.0, resulting in a Cu2+ concentration of 583°mg/kg in RJP-Cu. Scanning electron microscopy (SEM) revealed significant structural changes in RJP before and after chelation. RJP-Cu displaying characteristic peaks of both polysaccharides and Cu2+ chelates. Blood routine indexes showed no significant differences among the RJP-Cu-High dose group (RJP-Cu-H), RJP-Cu-Medium dose group (RJP-Cu-M), RJP-Cu-low dose group (RJP-Cu-L) and the control group (p > 0.05). However, compared with the control group, the RJP-Cu-H, M, and L dose groups significantly enhanced lamb production performance (p < 0.05). Furthermore, RJP-Cu-H, M, and L dose groups significantly increased serum Cu2+ concentration, total antioxidant capacity (T-AOC), catalase (CAT), and total superoxide dismutase (T-SOD) contents compared with control group (p < 0.05). The RJP-Cu-H group exhibited significant increases in serum IgA and IgG antibodies, as well as the secretion of cytokines IL-2, IL-4, and TNF-α compared to the control group (p < 0.05). Furthermore, RJP-Cu-H group increased the species abundance of lamb intestinal microbiota, abundance and quantity of beneficial bacteria, and decrease the abundance and quantity of harmful bacteria. The RJP-Cu-H led to the promotion of the synthesis of various Short Chain Fatty Acids (SCFAs), improvements in atrazine degradation and clavulanic acid biosynthesis in lambs, while reducing cell apoptosis and lipopolysaccharide biosynthesis.Conclusion: Thus, these findings demonstrate that RJP-Cu, as a metal chelate, could effectively promote lamb growth performance, increase Cu2+ content, and potentially induce positive immunomodulatory effects by regulating antioxidant enzymes, antibodies, cytokines, intestinal flora, and related metabolic pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation and activity study of Ruoqiang jujube polysaccharide copper chelate

Moheteer,

Li,

Abulikemu

et al. 2024

Front. Pharmacol.

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“…This could be attributed to the high amino acid digestibility of the CPC diet, which improved the overall development of broilers and consequently enhanced their antioxidant capacity. In addition, IgA, IgG, and IgM are considered important parameters reflecting the humoral immune status of animals [32,33]. The level of serum immunoglobulin to a certain extent reflects the immune function of animals, which helps to alleviate immune stress, improve health status, and improve growth performance [34].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Application Value of Cottonseed Protein Concentrate as a Feed Protein Source in Broiler Chickens

Chen,

Zhao,

Zheng

et al. 2023

Animals

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Cottonseed protein concentrate (CPC) has the function of replacing soybean meal to maintain normal animal growth and development. This study involved 180 Arbor Acres (AA) broilers, which were randomly assigned to three different treatments. Each treatment had six replicates, with each replicate consisting of 10 chicks. The control group was fed a basal diet, while the CPC-1 and CPC-2 groups used CPC to replace 25% and 50% of the soybean meal in the basal diet, respectively. The study showed that replacing soybean meal with 25% CPC in broilers’ diets can maintain normal growth, while substituting 50% of soybean meal with CPC negatively affects the growth and development of broiler chickens. Furthermore, the CPC-1 group showed a significant increase in serum total antioxidant capacity, superoxide dismutase enzyme activity, and immunoglobulin content, along with a decrease in malondialdehyde content. Based on the research results mentioned above, it was speculated that CPC has the potential to replace around 25% of soybean meal in broiler feed without causing any negative impact on growth performance. This suggests that CPC could be a viable alternative to soybean meal in broiler diet.

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“…The supplementation of dietary Chinese yam polysaccharide-Cu (0.10 g/kg) improved the growth, immunity, and oxidation resistance of broilers ( 28 ). Excess Cu induces hepatic cholesterol metabolism dysfunction, and the miR-455-3p-OXSR1 axis works as a regulator of autophagy under Cu stress ( 29 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

Integrated evaluation of the requirements and excretions of Cu, Fe, Zn, and Mn for broilers via a uniform design method

et al. 2023

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This study aimed to determine the ideal balance profile of Cu, Fe, Zn, and Mn for broilers of 1–21 days of age via a uniform experimental design. In Experiment 1, 900 1-day-old Arbor Acres male broilers were randomly allotted to 15 dietary treatments with six replicates of 10 birds. A total of 14 experimental diets were formulated with the supplementation of 8~16, 123~160, 40~80, and 60~120 mg/kg of Cu, Fe, Zn, and Mn, respectively, in the basal diet, according to the uniform design method. The excretion of Cu, Fe, Zn, and Mn in the manure and the broiler performance were determined to build the ideal balance profile of these elements. Experiment 2 was conducted based on the ideal balance profile built in Experiment 1, to test its practicability using 720 broilers with two treatments. The dietary concentrations of Cu, Fe, Zn, and Mn in the control group were 15.19, 203.08, 76.78, and 86.13 mg/kg, respectively. In Experiment 1, the concentrations of Cu, Fe, Zn, and Mn in the diets were 16.96, 166.66, 46.01, and 60.26 mg/kg, respectively, when the average daily gain reached the optimum value. When the dietary concentrations of Cu, Fe, Zn, and Mn were 8.54, 130.66, 38.19, and 64.07 mg/kg, respectively, the total excretion of Cu, Fe, Zn, and Mn got the minimum value. There are corresponding ideal balance profiles for minimum excretion of a certain element. In Experiment 2, the dietary levels of Fe, Zn, and Mn were decreased by 17.93%, 40.08%, and 30.04%, respectively, which had no significant effect on average daily gain, average daily feed intake, and feed gain for 1~21 day-old broilers but markedly decreased the excretion of Cu and Mn and total excretion. It was concluded that there is a dilemma between growth performance and mineral excretion. Although dietary levels of Cu, Fe, Zn, and Mn supporting optimal growth are higher than those for minimizing mineral excretion, supplementing too many trace elements in the diets of broilers is unnecessary.

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Effects of dietary Chinese yam polysaccharide copper complex on growth performance, immunity, and antioxidant capacity of broilers

Cited by 7 publications

References 39 publications

Preparation and activity study of Ruoqiang jujube polysaccharide copper chelate

Preparation and activity study of Ruoqiang jujube polysaccharide copper chelate

Evaluation of the Application Value of Cottonseed Protein Concentrate as a Feed Protein Source in Broiler Chickens

Integrated evaluation of the requirements and excretions of Cu, Fe, Zn, and Mn for broilers via a uniform design method

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