EFFECTS OF DIETARY CABBAGE (<i>BRASSICA OLERACEA</i> L.) ON THE TUMORIGENICITY OF 1, 2‐DIMETHYLHYDRAZINE IN MICE

Srisangnam, C.; Hendricks, Deloy G.; Sharma, Raghubir P.; Salunkhe, D. K.; Mahoney, Arthur W.

doi:10.1111/j.1745-4565.1980.tb00400.x

Cited by 17 publications

(3 citation statements)

References 15 publications

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“…Our results therefore seem at variance with several case-control studies which have indicated that cabbage or related cruciferous vegetables may be protective against colon cancer [5,7,12]. Srisangnani et al [18] also studied the effect of cabbage in DMH treated mice. In their model, tumors did not occur in the colon but were mainly in the spermatic cord followed by the liver and kidney.…”

Section: Discussioncontrasting

confidence: 78%

Cabbage and vitamin E: Their effect on colon tumor formation in mice

Temple

El-Khatib

1987

Cancer Letters

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The effects of cabbage and vitamin E on colon carcinogenesis were investigated in Swiss mice treated with 1,2-dimethylhydrazine. Throughout the experiment the mice were fed a laboratory chow diet (46 mg vitamin E per kg) or chow containing 13 g cabbage per 100 g or 180 mg vitamin E per kg. Starting after 31 days of diet treatment the mice received 7 weekly s.c. injections of DMH. They were sacrificed 17 weeks after the first dose of DMH. While diet did not significantly alter colon tumor response, some trends were observed. Female mice given cabbage had a higher incidence (percent of mice with a tumor) and multiplicity (tumors per tumor bearing mouse) of colon tumors. Males were little affected by cabbage apart from a lower incidence of adenocarcinomas. Compared with mice fed the control diet those given vitamin E had a higher colon tumor incidence. This effect, which was stronger in females, was due to an increased incidence of adenomas. Vitamin E had little apparent affect on tumor multiplicity apart from a reduction in adenocarcinomas in females and adenomas in males. The data do not support the view that cabbage and vitamin E are protective against colon cancer.

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Section: Discussioncontrasting

confidence: 78%

Cabbage and vitamin E: Their effect on colon tumor formation in mice

Temple

El-Khatib

1987

Cancer Letters

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“…Which nonnutnents in the vegetables-fruit mixture caused this protection cannot be determined from the results of the study, because a whole vegetables-fruit mixture was used and not specific nonnutrients. The inhibitory potency of vegetables and fruit or their components on the development of cancer has been described in several studies (21,22), including studies in which the animals were maintained on high-fat diets (23,24). However, it has also been observed that fat counteracts the anticarcinogenic effects of dietary components, such as fiber and cabbage (25,26).…”

Section: Discussionmentioning

confidence: 93%

Modulation of dietary fat‐enhanced colorectal carcinogenesis inN‐methyl‐N‘‐nitro‐N‐nitrosoguanidine‐treated rats by a vegetables‐fruit mixture

Rijnkels¹,

Hollanders

Woutersen

et al. 1997

Nutrition and Cancer

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The modulation of a vegetables-fruit mixture on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced colorectal carcinogenesis was studied in rats maintained on a low- or a high-fat diet. For this purpose, 120 rats received a semisynthetic diet without (Groups A and C) or with a vegetables-fruit mixture (19.5% wt/wt, Groups B and D) for 35 weeks. Diets of Group A and B contained 20 (low) energy percent (20e%) fat, whereas diets of Groups C and D contained 40e% (high) fat. Between Weeks 4 and 9 the animals were given weekly intrarectal instillations of 6 mg MNNG/kg body wt. The colorectal adenocarcinoma incidences showed a significant decrease in animals fed high-fat diets with a vegetables-fruit mixture compared with animals fed a high-fat diet alone. Furthermore, without a vegetables-fruit mixture, diets high in fat caused a significant increase in adenocarcinoma incidence compared with diets low in fat. Although not significant, the adenoma incidences tended to be lower in animals fed a vegetables-fruit mixture than in animals maintained on a diet without this mixture. The results demonstrate that a vegetables-fruit mixture has a significant inhibitory potency on the development of colorectal tumors induced by MNNG in rats fed diets high in fat.

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“…The inhibitory effect of dietary cabbage on 7,12-dimethylbenz(a) anthracene (DMBA)-induced mammary tumorigenesis in rats has been reported (9). Cabbage-containing diets also provide a protective effect against the tumori genicity of dimethylhydrazine (10,11).…”

mentioning

confidence: 99%