Modulation of dietary fat‐enhanced colorectal carcinogenesis inN‐methyl‐N‘‐nitro‐N‐nitrosoguanidine‐treated rats by a vegetables‐fruit mixture

Rijnkels, Jolanda M.; Hollanders, V.M.H.; Woutersen, Ruud; Koeman, J.H.; Alink, G.M.

doi:10.1080/01635589709514607

Cited by 8 publications

(1 citation statement)

References 23 publications

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“…Furthermore, a mixture of vegetables and fruits (including tomatoes) in the diet reduced N-methyl-N′-nitro-N-nitrosoguanidineinduced colon cancer in rats fed with high fat diet. 32) In in vitro studies, a potential anticancer activity of lycopene was demonstrated against human endometrial, lung and breast cancer cells, whereas human fibroblasts were less sensitive to growth inhibition by lycopene. 33) Furthermore, lycopene inhibited malignant transformation of C3H/ 10T1/2 cells initiated by 3-methylcholanthrene.…”

Section: Discussionmentioning

confidence: 99%

Prevention of N‐Methylnitrosourea‐induced Colon Carcinogenesis in F344 Rats by Lycopene and Tomato Juice Rich in Lycopene

Narisawa

Fukaura

Hasebe

et al. 1998

Japanese Journal of Cancer Research

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Epidemiological studies have suggested a protective effect of lycopene and lycopene-rich tomatoes against various cancers. Here, the inhibition of colon carcinogenesis by lycopene and tomato juice was investigated. Seven-week-old female F344/NSlc rats received an intrarectal dose of 2 mg (experiment I) or 4 mg (experiment II) of N-methylnitrosourea 3 times a week for 3 weeks, and had free access to one of 4 drinking fluids: plain water (control group), 17 ppm lycopene water solution (Ly group), and diluted tomato juice containing 17 ppm (Tj group) or 3.4 ppm (tj group) lycopene, throughout the experiments. The colon cancer incidence at week 35 was significantly lower in the Tj group, but not in the Ly group, than in the control group: 21% and 33% vs. 54%, in experiment I (24 rats in each group). It was significantly lower in the Tj group than in the tj and control groups, 40% vs. 72% and 84%, in experiment II (25 rats in each group). An appreciable amount of lycopene (0.02 µ µ µ µg/g) was detected in the colon mucosa of rats in the Tj group, but not in the tj group. The results suggest that tomato juice rich in lycopene may have a protective effect against colon carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Prevention of N‐Methylnitrosourea‐induced Colon Carcinogenesis in F344 Rats by Lycopene and Tomato Juice Rich in Lycopene

Narisawa

Fukaura

Hasebe

et al. 1998

Japanese Journal of Cancer Research

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Effects of vegetables–fruit extracts and indole-3-carbinol on stearic acid-modulated intercellular communication and cytochrome P450-IA activity

Rijnkels¹,

Delsing²,

Reijden³

et al. 1998

Environmental Toxicology and Pharmacology

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Absence of an inhibitory effect of a vegetables‐fruit mixture on the initiation and promotion phases of azoxymethane‐induced colorectal carcinogenesis in rats fed low‐ or high‐fat diets

Rijnkels

Hollanders²,

Woutersen³

et al. 1998

Nutrition and Cancer

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The potential inhibitory effects of a vegetables-fruit mixture on the initiation and promotion phases of azoxymethane-induced colorectal carcinogenesis were examined in rats fed low- or high-fat diets. Rats were fed low-fat diets (20 energy percent, Diets A and B) or high-fat diets (40 energy percent, Diets C and D), supplemented with a vegetables-fruit mixture (19.5% wt/wt, Diets B and D) or unsupplemented (Diets A and C) for 36 weeks. After the animals were maintained on the respective diets for four weeks, they were given three weekly injections of azoxymethane at 15 mg/kg body wt sc. Eight weeks after the start of the study, animals maintained on Diet A were switched to Diet B or C or maintained on the same diet. Animals maintained on Diet B or D were switched to Diet A or C, respectively. Furthermore, animals maintained on Diet C were switched to Diet A or D or maintained on the same diet. Multiplicity of colorectal tumors did not differ between groups fed a vegetables-fruit mixture during the initiation or the promotion phase (Group B-->A vs. Group A-->B; Group D-->C vs. Group C-->D). However, multiplicity was significantly lower in animals fed low-fat diets than in animals fed high-fat diets in combination with a vegetables-fruit mixture (Group A-->B/B--A vs. Group C-->D/D-->C). Furthermore, multiplicity was significantly increased in groups fed a high-fat diet during the promotion phase only in comparison with animals fed a low-fat diet during the whole experiment (Group A-->C vs. Group A-->A). No other differences in multiplicity or tumor incidences were observed among the eight experimental groups.

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Modulation of dietary fat‐enhanced colorectal carcinogenesis inN‐methyl‐N‘‐nitro‐N‐nitrosoguanidine‐treated rats by a vegetables‐fruit mixture

Cited by 8 publications

References 23 publications

Prevention of N‐Methylnitrosourea‐induced Colon Carcinogenesis in F344 Rats by Lycopene and Tomato Juice Rich in Lycopene

Prevention of N‐Methylnitrosourea‐induced Colon Carcinogenesis in F344 Rats by Lycopene and Tomato Juice Rich in Lycopene

Effects of vegetables–fruit extracts and indole-3-carbinol on stearic acid-modulated intercellular communication and cytochrome P450-IA activity

Absence of an inhibitory effect of a vegetables‐fruit mixture on the initiation and promotion phases of azoxymethane‐induced colorectal carcinogenesis in rats fed low‐ or high‐fat diets

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