Effects of Dietary Black Sea Cucumber on Serum and Liver Lipid Concentrations in Rats

Tanaka, Kazunari; Nishizono, Shoko; Kase, Ayako; Ogura, Sumiko; Kurita, M.; Murakami, Tomoko; Kugino, Kenji; Matsumoto, Hitoshi; Ikeda, Ikuo

doi:10.4327/jsnfs.56.175

Cited by 10 publications

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“…Researches on the influence of dietary whole sea cucumber on lipid metabolism have been much investigated. Tanaka K has found that dietary 5% black sea cucumber ( Stichophus japonicus ) revealed hypolipidemic effect in rats [ 25 ]. The results of Wang's study on sea cucumber ( Pearsonothuria graeffei and Apostichopus japonicus ) displayed its lipid-lowering effect in hypercholesteremic rats [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats

Zhang

Xue

et al. 2012

Lipids Health Dis

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BackgroundNonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease in industrialized countries. The present study was undertaken to explore the preventive effect of dietary sea cucumber cerebroside (SCC) extracted from Acaudina molpadioides in fatty liver rats.MethodsMale Wistar rats were randomly divided into four groups including normal control group, NAFLD model group, and two SCC-treated groups with SCC at 0.006% and 0.03% respectively. The fatty liver model was established by administration of 1% orotic acid (OA) to the rats. After 10d, serum and hepatic lipid levels were detected. And the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were also determined. Besides, to gain the potential mechanism, the changes of key enzymes and gene expressions related to the hepatic lipid metabolism were measured.ResultsDietary SCC at the level of 0.006% and 0.03% ameliorated the hepatic lipid accumulation in fatty liver rats. SCC administration elevated the serum triglyceride (TG) level and the ALT, AST activities in OA-fed rats. The activities of hepatic lipogenic enzymes including fatty acid synthase (FAS), malic enzyme (ME) and glucose-6-phosphatedehydrogenase (G6PDH) were inhibited by SCC treatment. And the gene expressions of FAS, ME, G6PDH and sterol-regulatory element binding protein (SREBP-1c) were also reduced in rats fed SCC. However, dietary SCC didn't affect the activity and mRNA expression of carnitine palmitoyltransferase (CPT) in liver. Besides, suppression of microsomal triglyceride transfer protein (MTP) activity was observed in SCC-feeding rats.ConclusionsThese results suggested that dietary SCC could attenuate hepatic steatosis due to its inhibition of hepatic lipogenic gene expression and enzyme activity and the enhancement of TG secretion from liver.

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Section: Introductionmentioning

confidence: 99%

Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats

Zhang

Xue

et al. 2012

Lipids Health Dis

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“…There is growing evidence that dietary sea cucumber could improve lipids metabolism in rats [ 9 , 10 ]. Sea cucumber, is a traditional seafood and important medical material in Asian countries, rich in various bioactive substance.…”

Section: Introductionmentioning

confidence: 99%

Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARα and SREBP-1c signaling

Wang

et al. 2010

Lipids Health Dis

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BackgroundNonalcoholic fatty liver disease is the most common chronic liver disease in the world, and is becoming increasingly prevalent. Saponins of sea cucumber (SSC) are proven to exhibit various biological activities. Therefore, the present study was undertaken to examine the effect of saponins extracted from sea cucumber (Pearsonothuria graeffei) on the preventive activity of fatty liver in rats.MethodsMale Wistar rats were randomly divided into five groups, including normal control group, fatty liver model group, SSC-treated group with SSC at levels of 0.01%, 0.03% and 0.05%. Model rats were established by administration with 1% orotic acid (OA). After the experiment period, serum total cholesterol (TC), triglyceride (TG), and hepatic lipid concentrations were determined. To search for a possible mechanism, we examined the changes of key enzymes and transcriptional factors involved in hepatic lipids biosynthesis, fatty acid β-oxidation.ResultsBoth 0.03% and 0.05% SSC treatment alleviated hepatic steatosis and reduced serum TG and TC concentration significantly in OA fed rats. Hepatic lipogenic enzymes, such as fatty acid synthase (FAS), malic enzyme (ME), and glucose-6-phosphate dehydrogenase (G6PDH) activities were inhibited by SSC treatment. SSC also decreased the gene expression of FAS, ME, G6PDH and sterol-regulatory element binding protein (SREBP-1c). Otherwise, the rats feeding with SSC showed increased carnitine palmitoyl transferase (CPT) activity in the liver. Hepatic peroxisome proliferator-activated receptor (PPARα), together with its target gene CPT and acyl-CoA oxidase (ACO) mRNA expression were also upregulated by SSC.ConclusionsAccording to our study, the lipids-lowering effect of dietary SSC may be partly associated with the enhancement of β-oxidation via PPARα activation. In addition, the inhibited SREBP-1c- mediated lipogenesis caused by SSC may also contribute to alleviating fatty liver.

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“…Many bioactive substances, such as saponins, cerebrosides, polysaccharides, and collagen peptides have been found and isolated from sea cucumber. There is growing evidence that dietary sea cucumber could improve lipid metabolism in animals (1,2). Saponins, as the most important secondary metabolite and bioactive component of sea cucumber, exhibit various biological activities, such as antifungal, anti-angiogenesis, anti-tumor and immunomodulatory effects (3)(4)(5).…”

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Sea Cucumber Saponin Echinoside A (EA) Stimulates Hepatic Fatty Acid β-Oxidation and Suppresses Fatty Acid Biosynthesis Coupling in a Diurnal Pattern

Wen

Han

et al. 2016

J Nutr Sci Vitaminol

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Circadian rhythms control aspects of physiological events, including lipid metabolism, showing rhythmic fluctuation over 24 h. Therefore, it is not sufficient to evaluate thoroughly how dietary components regulate lipid metabolism with a single time-point assay. In the present study, a time-course study was performed to analyze the effect of sea cucumber saponin echinoside A (EA) on lipid metabolism over 24 h. Results showed that EA lowered the levels of TC and TG in both serum and liver at most time-points during the 24 h. Activities of hepatic lipogenic enzymes and lipolytic enzymes were inhibited and elevated respectively by EA to varied degrees at different time-points. Meanwhile, parallel variation trends of gene expression involved in fatty acid synthesis and β-oxidation were observed accordingly. The interaction between EA and lipid metabolism showed a time-dependent effect. Overall, EA impaired fatty acid synthesis and enhanced mitochondrial fatty acid β-oxidation in ad libitum feeding over 24 h.

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Effects of Dietary Black Sea Cucumber on Serum and Liver Lipid Concentrations in Rats

Cited by 10 publications

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Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats

Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats

Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARα and SREBP-1c signaling

Sea Cucumber Saponin Echinoside A (EA) Stimulates Hepatic Fatty Acid β-Oxidation and Suppresses Fatty Acid Biosynthesis Coupling in a Diurnal Pattern

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Effects of Dietary Black Sea Cucumber on Serum and Liver Lipid Concentrations in Rats

Cited by 10 publications

References 0 publications

Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats

Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats

Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARα and SREBP-1c signaling

Sea Cucumber Saponin Echinoside A (EA) Stimulates Hepatic Fatty Acid &beta;-Oxidation and Suppresses Fatty Acid Biosynthesis Coupling in a Diurnal Pattern

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Sea Cucumber Saponin Echinoside A (EA) Stimulates Hepatic Fatty Acid β-Oxidation and Suppresses Fatty Acid Biosynthesis Coupling in a Diurnal Pattern