Effects of Diet on Telomere Length: Systematic Review and Meta-Analysis

Pérez, Lisiane Marçal; Amaral, Marina Azambuja; Mundstock, Eduardo; Barbé-Tuana, Florencia Marı́a; Guma, Fátima Theresinha Costa Rodrigues; Jones, Marcus Herbert; Machado, Denise Cantarelli; Sarria, Edgar E.; Marques, Maximiniano Marques e; Preto, Luiza Tweedie; Epifânio, Matias; Garbin, João Guilherme Meinem; Mattiello, Rita

doi:10.1159/000486586

Cited by 34 publications

(18 citation statements)

References 30 publications

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“…Interestingly, telomere length measured from subcutaneous adipocytes was significantly lower in obese patients compared to never-obese ones (27), and it appears that physical activity may protect patients from telomere shortening due to obesity, although extended periods of overweight/obesity seem to mitigate this protection (28). It should be noted that these results are not consistent in all studies (29).…”

Section: Telomere Attritionmentioning

confidence: 58%

Obesity May Accelerate the Aging Process

2019

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Lines of evidence from several studies have shown that increases in life expectancy are now accompanied by increased disability rate. The expanded lifespan of the aging population imposes a challenge on the continuous increase of chronic disease. The prevalence of overweight and obesity is increasing at an alarming rate in many parts of the world. Further to increasing the onset of metabolic imbalances, obesity leads to reduced life span and affects cellular and molecular processes in a fashion resembling aging. Nine key hallmarks of the aging process have been proposed. In this review, we will review these hallmarks and discuss pathophysiological changes that occur with obesity, that are similar to or contribute to those that occur during aging. We present and discuss the idea that obesity, in addition to having disease-specific effects, may accelerate the rate of aging affecting all aspects of physiology and thus shortening life span and health span.

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Section: Telomere Attritionmentioning

confidence: 58%

Obesity May Accelerate the Aging Process

2019

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“…Telomere length and therefore efficiency has been associated with numerous diseases (Calado & Young, 2009;Haycock et al, 2014). Although the effects of dietary patterns on telomere length are discussed controversially (Pérez et al, 2017;Vidacek et al, 2017), one may speculate that affecting telomere length might represent another mode of action in the health-promoting effects of MedDiet. This effect could be achieved by influencing the telomerase activity.…”

Section: Telomerase Activitymentioning

confidence: 99%

Mediterranean diet and health status: Active ingredients and pharmacological mechanisms

Schwingshackl

Morze

Hoffmann

2019

British J Pharmacology

179

105

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The Mediterranean diet (MedDiet) is one of the most widely described and evaluated dietary patterns in scientific literature. It is characterized by high intakes of vegetables, legumes, fruits, nuts, grains, fish, seafood, extra virgin olive oil, and a moderate intake of red wine. A large body of observational and experimental evidence suggests that higher adherence to the MedDiet is associated with lower risk of mortality, cardiovascular disease, metabolic disease, and cancer. Current mechanisms underlying the beneficial effects of the MedDiet include reduction of blood lipids, inflammatory and oxidative stress markers, improvement of insulin sensitivity, enhancement of endothelial function, and antithrombotic function. Most likely, these effects are attributable to bioactive ingredients such as polyphenols, monounsaturated and polyunsaturated fatty acids, or fibre. This review will focus on both established and less established mechanisms of action of biochemical compounds contained in a MedDiet. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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“…43,44 Interestingly, the effect of diet interventions has been shown to have only minor to no effect on telomeres. 45,46 In our cohort, STL Age is a well-investigated parameter for telomere lengths, and advanced age is associated with a decrease in leucocytes 54 and increase in spermatozoa. 55 The ageing protection mechanism of telomere length in leucocytes is well defined in the literature, whereas the mechanism of STL elongation remains currently unclear.…”

Section: Discussionmentioning

confidence: 85%

Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples

et al. 2019

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Background: Many studies have demonstrated that lifestyle factors can affect sperm quality and fertility. Sperm telomere length (STL) has been reported as potential biomarker or sperm quality. However, no studies have investigated how lifestyle factors can affect STL and associated clinical outcomes. Objectives:The purpose of this manuscript is to investigate any association between STL with lifestyle factors, semen parameters and clinical outcomes. Materials and methods:Sperm telomere length was measured using real-time PCR in normozoospermic male partners (n = 66) of couples undergoing ART treatment. Each participant also completed a detailed questionnaire about general lifestyle. Linear regression univariate analysis and ANCOVA were performed to respectively determine correlations between STL and study parameters or identify statistically significant differences in STL while controlling for age, BMI and other factors. Results:Using a linear regression model, STL is positively correlated with in vitro fertilization success (n = 65, r = 0.37, P = .004) but not with embryo cleavage rates and post-implantation clinical outcomes including gestational age-adjusted birth weight.No associations were observed between STL and sperm count, concentration or progressive motility. We further found that STL did not associate age, BMI, health or lifestyle factors. Discussion: In somatic cells, the rate of telomere shortening is influenced by a number of lifestyle factors such as smoking, diet and occupation. However, little is known about how lifestyle factors affect STL and subsequently reproductive outcome. Out data suggest that STL might have an important role mechanistically for fertilization rate regardless of sperm parameters and lifestyle factors. Conclusion: The results of this study demonstrate that STL is associated with in vitro fertilization rates, but not with semen parameters nor lifestyle factors. Further How to cite this article: Berneau SC, Shackleton J, Nevin C, et al. Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples. Andrology. 2020;8:583-593.

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Effects of Diet on Telomere Length: Systematic Review and Meta-Analysis

Cited by 34 publications

References 30 publications

Obesity May Accelerate the Aging Process

Obesity May Accelerate the Aging Process

Mediterranean diet and health status: Active ingredients and pharmacological mechanisms

Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples

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