Effects of diclofenac on periosteal callus maturation in osteotomy healing in an animal model

Krischak, Gert; Augat, Peter; Sorg, Tobias; Blakytny, Robert; Kinzl, L.; Claes, Lutz; Beck, Alexander

doi:10.1007/s00402-006-0202-x

Cited by 60 publications

(50 citation statements)

References 23 publications

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“…Interestingly, NSAIDs have recently been shown to retard radiographic progression of AS in the spine, as determined in patients treated with a daily dose of an NSAID compared with those receiving NSAID therapy on demand over 2 years (13), confirming the findings of a much earlier study with phenylbutazone in AS (45). This effect of NSAIDs might be explained through the inhibition of osteoblasts by prostaglandin blockade (46). It was also recently shown that the NSAID diclofenac reduced the appearance of osteoblasts in a rat model of bone defect healing (47).…”

Section: Clinical Relevance Of Osteoproliferation In As and Its Theramentioning

confidence: 99%

Critical appraisal of assessment of structural damage in ankylosing spondylitis: Implications for treatment outcomes

Sieper¹,

Appel²,

Braun³

et al. 2008

Arthritis & Rheumatism

203

106

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Section: Clinical Relevance Of Osteoproliferation In As and Its Theramentioning

confidence: 99%

Critical appraisal of assessment of structural damage in ankylosing spondylitis: Implications for treatment outcomes

Sieper¹,

Appel²,

Braun³

et al. 2008

Arthritis & Rheumatism

203

106

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“…Another significant advantage of the use of nerve blocks in the ambulatory patient is that this technique decreases the frequency of unanticipated admissions and readmissions after same-day surgery, together with their associated costs [33]. It has also been shown that the administration of nonsteroidal anti-inflammatory agents, such as tenoxicam [35] and diclofenac [29], and of opioids like morphine [36] leads to delay in the fracture healing process. However, the application of femoral block, leads to a decrease in the use of nonsteroidal anti-inflammatory agent and opioids for pain management at the perioperative period, and is beneficial from the fracture healing perspective.…”

Section: Discussionmentioning

confidence: 99%

The effect of femoral nerve block on fracture healing via expressions of growth factors and β-catenin

Uslu

İrban

Gereli

et al. 2016

Folia Histochem Cytobiol.

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Introduction. Many patients of all ages are admitted to hospital due to bone fractures. The etiology of fracture has a very wide spectrum, ranging from motor accidents to pathological conditions such as tumors, osteoporosis, and others. Bone fracture healing is a well-programmed and well-organized process, but is also long and intractable. The outcome of this process is therefore affected by many factors, such as the patient's age, ethnicity, nutritional status, and extent of the fracture. At present, regional analgesic techniques are frequently applied in order to avoid the complications of systemic opioid administration, central block applications. Femoral block is one of the regional analgesic techniques frequently applied by anesthesiologists when the lower extremities are involved. In this study, we evaluated the effect of femoral nerve block on the healing of an experimental non-stabilized femur fracture via expression of TGF-b, VEGF, and b-catenin and bone histomorphometry in rats. Material and methods. In the control group, only the femoral fracture was performed and the bone was not fixated, similarly as in other groups. In the One-Day Block group, a one-time femoral nerve block was applied after the femoral fracture. In the Three-Day Block group, a daily femoral nerve block was performed for three days after the femoral fracture. On Days 4, 7, and 13, femurs were excised. The bone sections were stained with hematoxylin-eosin to evaluate bone tissue and Safranin O to assess callus tissue, cartilaginous tissue, and new bone areas. TGF-b, VEGF, and b-catenin were assessed by immunohistochemistry. Results. Histomorphometric analysis revealed that femoral block application had a positive impact on bone healing. TGF-b expression in the One-Day and Three-Day Block Groups was significantly higher than in the control group at all times, as was also the case with VEGF expression. On day 13, b-catenin expression was significantly higher in the Three-Day Block group than the others. Conclusions. The results of the study suggests that the applications of a femoral nerve block for perioperative analgesia, for either one day or three days, resulted in better and more rapid bone healing. (Folia Histochemica et Cytobiologica 2016, Vol. 54, No. 3, 151-158)

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“…4 evidence to generally support the withholding of NSAIDs after orthopaedic surgery (Dimmen et al, 2009;Krischak et al, 2007). There is evidence from experimental studies in rabbits and rodents, that most NSAIDs have the potential to inhibit bone healing in the short-term perspective, depending on the timing, dose and duration (Endo et al, 2005;Gerstenfeld et al, 2003;Simon et al, 2002).…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Carprofen neither reduces postoperative facial expression scores in rabbits treated with buprenorphine nor alters long term bone formation after maxillary sinus grafting

Hedenqvist

Trbakovic

Thor

et al. 2016

Research in Veterinary Science

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In connection with bilateral maxillary sinus augmentation, the acute effects of the nonsteroidal anti-inflammatory drug carprofen on facial expression and long-term effects on bone formation were evaluated in 18 male New Zealand White rabbits. A 10 x 10-mm bone window was drilled in the maxilla, the sinus membrane elevated and a titanium mini-implant inserted. One of two test materials was randomly inserted unilaterally and bovine bone chips (control) on the contralateral side in the created space. Rabbits were randomly allocated to receive buprenorphine plus carprofen (n=9) or buprenorphine plus saline (n=9) postoperatively. Buprenorphine was administered subcutaneously every 6 h for 3 d in a tapered dose (0.05-0.01 mg/kg) and carprofen (5 mg/kg) or saline administered subcutaneously 1 h before, and daily for 4 d postoperatively. To assess pain, clinical examination, body weight recording and scoring of facial expression from photos taken before, and 6-13 h after surgery was performed. Twelve weeks after surgery the rabbits were euthanized and sections of maxillary bones and sinuses were analysed with histomorphometry and by qualitative histology.Carprofen had no effect on mean facial expression scores, which increased from 0.0 to 3.6 (carprofen) and 4.3 (saline), of a maximum of 8.0. Neither did carprofen have an effect on bone formation or implant incorporation, whereas the test materials had.In conclusion, treatment with 5 mg/kg carprofen once daily for 5 d did not reduce facial expression scores after maxillary sinus augmentation in buprenorphine treated rabbits and did not affect long term bone formation.

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Effects of diclofenac on periosteal callus maturation in osteotomy healing in an animal model

Abstract: Callus maturation in vivo was impaired after long-term application of diclofenac which corresponds to the in vitro findings of a dose-dependent effect of NSAIDs on osteoblast proliferation.

Cited by 60 publications

References 23 publications

Critical appraisal of assessment of structural damage in ankylosing spondylitis: Implications for treatment outcomes

Critical appraisal of assessment of structural damage in ankylosing spondylitis: Implications for treatment outcomes

The effect of femoral nerve block on fracture healing via expressions of growth factors and β-catenin

Carprofen neither reduces postoperative facial expression scores in rabbits treated with buprenorphine nor alters long term bone formation after maxillary sinus grafting

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