2010
DOI: 10.1016/j.ijdevneu.2010.09.008
View full text | Cite
|
Sign up to set email alerts
|

Abstract: Despite restrictions, exposure to lead (Pb) continues. Moreover, exposure varies and is often higher in lower socioeconomic status (SES) families and remains a significant risk to cognitive development. Stress is another risk factor. Lower SES may be a proxy for stress in humans. When stress and Pb co-occur, risk may be increased. A few previous experiments have combined Pb with intermittent or acute stress but not with chronic stress. To determine if chronic developmental stress affects outcome in combination… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

5
38
1

Year Published

2016
2016
2018
2018

Publication Types

Select...
3

Relationship

2
1

Authors

Journals

citations
Cited by 29 publications
(44 citation statements)
references
References 142 publications
(184 reference statements)
5
38
1
Order By: Relevance
“…Gavage solutions were given in a volume of 3 mL/kg of VEH every other day from P4-28. Gavage was used to avoid maternal exposure and its effects on maternal-pup behavior (Graham et al, 2011). This exposure regimen produces increased serum and brain Mn (Amos-Kroohs et al, 2015) but does not increase corticosterone above that of untreated littermates (Graham et al, 2011).…”
Section: Methodsmentioning
confidence: 99%
“…The level of oxidative stress markers such as protein carbonyl and lipid peroxidation observed in LA treated rats were increased, whereas the activity of enzymatic antioxidants, non-enzymatic antioxidants and neurotoxicity biomarker were strongly depleted. Developmental stress induced by the accumulation of lead was studied previously [25][26][27][28][29][30]. Liu et al (2013) evaluated the impact of puerarin and its protective effect on mice lead-induced cognitive impairment by modifying the enzyme activities, including, nitric oxide synthase, monoamine oxidase, and acetyl cholinesterase [25].…”
Section: Monoamenesmentioning
confidence: 99%
“…Standard-caged housing was as described above. For barren-caged housing, the woodchip bedding and stainless steel hut were replaced with a single paper towel, as described in Gilles et al (1996), with modification (Graham et al 2011). Cages and paper towels were changed each day.…”
Section: Methodsmentioning
confidence: 99%
“…Tissue concentrations of DA, DOPAC, homovanillic acid (HVA), norepinephrine (NE), 5-HT, and 5-hydroxyindoleacetic acid (5-HIAA) in the neostriatum, hippocampus, and prefrontal cortex were quantified via high performance liquid chromatography with electrochemical detection (as described in Graham et al 2011). Frozen samples (−80 °C) were weighed, thawed, and sonicated in proper volumes of 0.1 N perchloric acid (Fisher Scientific, Pittsburgh, PA) and centrifuged at 4 °C for 14 min (13,000 RCF).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation