Effects of denervation on cell-to-cell communication between acinar cells of rat submandibular salivary gland

Kanno, Yoshinobu; Sasaki, Yasuto; Shiba, Yoshiki

doi:10.1016/0003-9969(87)90152-x

Cited by 7 publications

(1 citation statement)

References 21 publications

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“…The notion that it depends upon changes in membrane receptor density or affinity has not accrued compelling support from studies of these phenomena. There has been speculation that it might also relate to increases in intercellular coupling (Emmelin, 1987) but this has not been substantiated in the submandibular gland of the rat (Kanno, Sasaki & Shiba, 1987).…”

Section: Discussionmentioning

confidence: 99%

Submandibular responses to stimulation of the sympathetic innervation following parasympathetic denervation in cats.

Edwards¹,

Garrett²

1988

The Journal of Physiology

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SUMMARY1. The effects of continuous stimulation of the ascending cervical sympathetic nerve were compared with those of intermittent stimulation in bursts, so arranged as to deliver the same total number of impulses, in cats under chloralose anaesthesia 3 weeks after excision of the chorda tympani.2. Parasympathetic denervation of the gland in this way enhanced the vasodilator component of the vascular response during sympathetic stimulation in bursts. During continuous stimulation this was manifested as a reduced rise in submandibular vascular resistance (SVR). It also produced a profound increase in the secretory response to sympathetic stimulation at low intensity (2 Hz continuously).3. Enhancement of the salivary secretory responses by stimulating intermittently at relatively high frequencies resembled that which developed following parasympathetic denervation in that there was no change in the secretory capacity during maximal or supramaximal stimulation.4. Pre-treatment with atropine substantially reduced the flow of saliva in response to sympathetic stimulation at low frequencies (2 and 5 Hz continuously) and combined pre-treatment with atropine and propranolol effectively reversed the increase in secretory sensitivity due to parasympathetic denervation indicating that ,1-adrenergic and muscarinic responses are involved. Additional pre-treatment with dihydroergotamine effectively abolished the secretory response to sympathetic stimulation.5. Stimulation in bursts was found to have a significantly greater vasodilator effect than continuous stimulation at the corresponding frequency after parasympathetic denervation.6. Neither pre-treatment with atropine nor combined pre-treatment with atropine and propranolol had any significant effect on the changes in mean SVR at any frequency tested during or after either pattern of stimulation. Additional pretreatment with dihydroergotamine effectively abolished the vascular responses to sympathetic stimulation both continuous (5 Hz) and in bursts (50 Hz), leaving a small vasoconstrictor response that may be due to release of neuropeptide Y (NPY).A. V. EDWARDS AND J. R. GARRETT 7. These results suggest that cholinergic ,-adrenergic and NPY supersensitivities are not involved in the submandibular vascular changes that result from parasympathetic denervation, but that a-mediated secondary vasodilator mechanisms are thereby enhanced.

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Section: Discussionmentioning

confidence: 99%

Submandibular responses to stimulation of the sympathetic innervation following parasympathetic denervation in cats.

Edwards¹,

Garrett²

1988

The Journal of Physiology

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The role of gap junction membrane channels in secretion and hormonal action

Meda

1996

J Bioenerg Biomembr

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Connexins, gap junctions, and coupling are obligatory features of both endocrine and exocrine glandular epithelia. Evidence from these two types of tissues, and particularly from pancreatic islets and acini, indicates that cell-to-cell communication via gap junction channels is required for proper biosynthesis, storage, and release of specific secretory products. However, endocrine and exocrine glands express a different set of connexins and show opposite connexin and coupling changes in relation with the activation and inhibition of their secretory function. Also, several hormones modulate connexin and coupling expression, and junctional coupling affects hormonal stimulation. These observations indicate that gap junction channels play an important role in the control of secretion and hormonal action.

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Effect of parasympathectomy on the histochemical maturation of myoepithelial cells of the rat sublingual salivary gland

Murakami

Nagato

Tanioka

1991

Archives of Oral Biology

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Effects of denervation on cell-to-cell communication between acinar cells of rat submandibular salivary gland

Cited by 7 publications

References 21 publications

Submandibular responses to stimulation of the sympathetic innervation following parasympathetic denervation in cats.

Submandibular responses to stimulation of the sympathetic innervation following parasympathetic denervation in cats.

The role of gap junction membrane channels in secretion and hormonal action

Effect of parasympathectomy on the histochemical maturation of myoepithelial cells of the rat sublingual salivary gland

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