Effects of demographic, dietary and other lifestyle factors on the prevalence of hyperlipidemia in Guangxi Hei Yi Zhuang and Han populations

Yin, Rong; Chen, Yuming; Pan, Shang‐Ling; He, Fang; Liu, Tangwei; Dezhai, Yang; Wu, Jin‐Zhen; Yao, Limei; Lin, Wei; Li, Rongshan; Jiandong, Huang

doi:10.1097/01.hjr.0000239476.79428.25

Cited by 53 publications

(107 citation statements)

References 30 publications

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“…Ruixing et al reported that the prevalence of hyperlipidemia was positively correlated with alcohol consumption [48]. We observed a strong positive association between alcohol consumption and dyslipidemia.…”

Section: Discussionsupporting

confidence: 68%

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Prevalence of dyslipidemia and associated risk factors among Turkish adults: Trabzon lipid study

Erem

Hacıhasanoğlu

Değer

et al. 2008

Endocr

109

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The objective of this study was to estimate the prevalence of dyslipidemia as defined by NCEP ATP III criteria in the Trabzon Region of Turkey and to determine its associations with cardiovascular risk factors [hypertension (HT), body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and fasting serum glucose (FBG)] demographic factors (age, sex, obesity, marital status, reproductive history in women, and level of education), socioeconomic factors (household income and occupation), a family history of selected medical conditions (diabetes, HT, obesity, and cardiovascular disease), and lifestyle factors (smoking habits, physical activity, and alcohol consumption) in the adult population. In this cross-sectional survey, a sample of households was systematically selected from the central province of Trabzon city and its nine towns, namely, Akcaabat, Duzkoy, Vakfikebir, Yomra, Arakli, Of, Caykara, Surmene, and Macka. A total of 4,809 subjects (2,601 women and 2,208 men) were included in the study. Individuals older than 20 years were selected from their family health cards. Demographic and socioeconomic factors, a family history of selected medical conditions, and lifestyle factors were obtained for all participants. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels were measured for all subjects. The individuals included in the questionnaire were invited to the local medical centers for blood tests between 08:00 and 10:00 after 12 h of fasting. The levels of serum glucose (FBG), total cholesterol (TC), high-density cholesterol (HDL-C), low-density cholesterol (LDL-C), and trigylcerides were measured with autoanalyzer. Dyslipidemia was defined according to guidelines from the US NCEP ATP III diagnostic criteria. The ratio of TC to HDL-C was calculated. Definition and classification of HT were performed according to guidelines from the US JNC-7 report. The results obtained indicated that the age-adjusted mean values (mg/dl) of TC, LDL-C, HDL-C, [TC/HDL-C ratio], and TG were 190 +/- 0.6, 127.5 +/- 0.5, 50.3 +/- 0.3, 3.96 +/- 0.02, and 137.3 +/- 1.5, respectively. Overall, the mean levels of LDL-C, TG and TC/HDL-C ratio were higher in men than in women, whereas the mean level of HDL-C was higher in women than in men. The prevalences of hypercholesterolemia (> or =200 mg/dl), elevated LDL-C (> or =130 mg/dl), low HDL-C (<40 mg/dl), and hypertriglyceridemia (> or =150 mg/dl) were 37.5, 44.5, 21.1, and 30.4%, respectively. Prevalences of dyslipidemia were higher in men than in women, except for TC (P < 0.0001). The prevalences of high TC, LDL-C, TG, and TC/HDL-C ratio increased with age, with the highest prevalences in the 60-69-year-old group, and declined thereafter. The prevalences of high TC, LDL-C and TG, a high TC/HDL-C ratio and low HDL-C increased steadily in line with BP, BMI, WC, WHR, and FBG (P < 0.0001). Dyslipidemia was positively associated with marital status, parity, cessation of cigarette smoking and current cigarette use, and alcohol consumption, and negatively as...

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Section: Discussionsupporting

confidence: 68%

“…Obesity not only increases the prevalence of dyslipidemia, but is also directly associated with HT, diabetes, and CHD [48]. Dyslipidemia in obesity may be the result of insulin resistance [49].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of dyslipidemia and associated risk factors among Turkish adults: Trabzon lipid study

Erem

Hacıhasanoğlu

Değer

et al. 2008

Endocr

109

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“…During the same period, a total of 540 subjects of Han Chinese who reside in the same county were also randomly selected from our previous stratified randomized cluster samples. 63 The average age of the subjects was 43.22 (SD, 16.52) years (range, 15-89 years). There were 262 males (48.52%) and 278 females (51.48%).…”

Section: Methodsmentioning

confidence: 99%

“…The individuals with TC greater than 5.17 mmol/L and/or TG greater than 1.70 mmol/L were defined as hyperlipidemic. 63 Hypertension was diagnosed according to the criteria of the 1999 World Health Organization-International Society of Hypertension Guidelines for the management of hypertension. 64 The diagnostic criteria of overweight and obesity were according to the Cooperative Meta-analysis Group of China Obesity Task Force.…”

Section: Methodsmentioning

confidence: 99%

“…We have previously found that there were significant differences in serum lipid profiles between the 2 ethnic groups. 63 We hypothesize that some environmental and genetic factors may be responsible for this discrepancy. Therefore, the aim of the present study was to detect the association of the apoC-III 3238C>G polymorphism and several environmental factors with serum lipid profiles in the Guangxi Hei Yi Zhuang and Han populations.…”

mentioning

confidence: 95%

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Apolipoprotein C-III Gene Polymorphism and Several Environmental Factors with Serum Lipid Levels in the Guangxi Hei Yi Zhuang and Han Populations

Yin

et al. 2010

Journal of Investigative Medicine

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Hepatic Lipase Gene −514C/T Polymorphism in the Guangxi Hei Yi Zhuang and Han Populations

Yin

Lin

et al. 2008

Lipids

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Hei Yi Zhuang is an isolated subgroup of the Zhuang minority in China. This study was designed to compare the difference in the hepatic lipase gene (LIPC) -514C/T polymorphism and its association with lipid profiles between the Guangxi Hei Yi Zhuang and Han populations. Genotyping of the LIPC -514C/T was performed in 873 subjects of Hei Yi Zhuang and 867 participants of Han Chinese. The frequency of -514T allele was 43.47% in Hei Yi Zhuang, and 36.10% in Han (P < 0.001). The frequencies of CC, CT and TT genotypes were 30.01, 53.04 and 16.95% in Hei Yi Zhuang, and 40.95, 45.91 and 13.14% in Han (P < 0.001); respectively. Serum high-density lipoprotein cholesterol (HDL-C) and apolipoprotein B levels in both ethnic groups were higher in LIPC -514T carriers than in C carriers. In addition, serum triglyceride levels in Han were higher in TT genotype individuals than in CC genotype subjects (P < 0.05). Serum HDL-C levels were positively correlated with age, alcohol consumption and LIPC -514C/T genotypes, and negatively associated with hypertension and cigarette smoking in Hei Yi Zhuang (P < 0.05-0.01), whereas HDL-C levels were positively correlated with age, alcohol consumption and LIPC -514C/T genotypes, and negatively associated with body mass index and cigarette smoking in Han (P < 0.05-0.001). The differences in serum HDL-C levels between the two ethnic groups might partially attribute to the differences in the LIPC -514C/T polymorphism.

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Effects of demographic, dietary and other lifestyle factors on the prevalence of hyperlipidemia in Guangxi Hei Yi Zhuang and Han populations

Abstract: The current study reveals that there is a significant difference in the prevalence of hyperlipidemia and its risk factors between Hei Yi Zhuang and Han, which might result from different demographic characteristics, dietary habits and other lifestyle factors.

Cited by 53 publications

References 30 publications

Prevalence of dyslipidemia and associated risk factors among Turkish adults: Trabzon lipid study

Prevalence of dyslipidemia and associated risk factors among Turkish adults: Trabzon lipid study

Apolipoprotein C-III Gene Polymorphism and Several Environmental Factors with Serum Lipid Levels in the Guangxi Hei Yi Zhuang and Han Populations

Hepatic Lipase Gene −514C/T Polymorphism in the Guangxi Hei Yi Zhuang and Han Populations

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