Effects of Deletion-Type Human Hepatocyte Growth Factor on Murine Septic Model

Kondo, Hiroyuki; Tani, Tohru; Kodama, Masashi

doi:10.1006/jsre.1999.5643

Cited by 9 publications

(11 citation statements)

References 27 publications

(22 reference statements)

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“…This might be beneficial for the patient, as suggested by other studies in other patient groups [10] and in experimental studies [11]. More patient studies are needed to confirm this hypothesis in meningitis.…”

Section: Discussionsupporting

confidence: 59%

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Hepatocyte Growth Factor Levels in Cerebrospinal Fluid: A Comparison between Acute Bacterial and Nonbacterial Meningitis

et al. 2000

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The organotrophic functions of the hepatocyte growth factor (HGF) have been the subject of several studies. In the more recent studies, this function has been reported in the brain. In the present study, we have measured the levels of HGF in cerebrospinal fluid (CSF) and sera from 78 patients divided into 6 different groups according to central nervous system (CNS) infection and control. Quantitative measurements of HGF in the CSF and serum were performed by an enzyme-linked immunosorbent assay. Elevated values of CSF HGF were found in the patients with acute bacterial/probable bacterial meningitis (P<.001), compared with nonbacterial CNS infections and facial palsy, as well as with a control group without signs of CNS involvement. The values of CSF HGF were not correlated to blood-brain-barrier disruption in the groups. These observations might indicate an intrathecal production of HGF in acute bacterial/probable bacterial meningitis.

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Section: Discussionsupporting

confidence: 59%

“…Some studies have shown the prognostic values of HGF in inflammatory diseases [9][10]. As an agent that promotes regeneration of epithelial cells, the potential therapeutic value of HGF has been investigated in severe infectious diseases [11].…”

Section: Discussionmentioning

confidence: 99%

Hepatocyte Growth Factor Levels in Cerebrospinal Fluid: A Comparison between Acute Bacterial and Nonbacterial Meningitis

et al. 2000

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“…Recent studies have strengthened the notion that HGF plays an important role in the regeneration of an injured organ [2]. Several researchers have attempted to treat induced hazardous injuries in animal models by HGF [14,15]. We have studied HGF during infectious diseases and found that HGF was produced in high amounts both systemically and locally during injuries caused by infection [8].…”

Section: Discussionmentioning

confidence: 99%

Hepatocyte growth factor (HGF) in fecal samples: rapid detection by surface plasmon resonance

et al. 2005

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“…Using CLP-treated rats as a model of septic peritonitis, Kondo et al demonstrated the therapeutic efficacy of recombinant HGF, especially for attenuation of MOF. After the surgery of CPL, hepatic degeneration became evident in rats, along with leukocyte infiltration [45]. In contrast, recombinant HGF inhibited CLP-associated hepatitis in rats.…”

Section: Therapeutic Effects Of Hgf On Mof During Sepsismentioning

confidence: 99%

Improvement of Sepsis by Hepatocyte Growth Factor, an Anti-Inflammatory Regulator: Emerging Insights and Therapeutic Potential

Mizuno

Nakamura

2012

Gastroenterology Research and Practice

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Sepsis-induced multiple organ failure (MOF) is the most frequent lethal disease in intensive care units. Thus, it is important to elucidate the self-defensive mechanisms of sepsis-induced MOF. Hepatocyte growth factor (HGF) is now recognized as an organotrophic factor, which is essential for organogenesis during embryonic growth and regeneration in adulthood. HGF production is enhanced in response to infectious challenges, but the increase in endogenous HGF levels is transient and insufficient, with a time lag between tissue injuries and HGF upregulation, during progression of septic MOF. Thus, administration of active-formed HGF might be a new candidate for therapeutic development of MOF. HGF has an ability to target endotoxin-challenged macrophages and inhibits the upregulation of inflammatory cytokines through nuclear factor-κB-inactivated mechanisms. HGF also targets the endothelium and epithelium of various organs to suppress local inflammation, coagulation, and apoptotic death. This paper summarizes the novel mechanisms of HGF for attenuating sepsis-related pathological conditions with a focus on sepsis-induced MOF.

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Effects of Deletion-Type Human Hepatocyte Growth Factor on Murine Septic Model

Cited by 9 publications

References 27 publications

Hepatocyte Growth Factor Levels in Cerebrospinal Fluid: A Comparison between Acute Bacterial and Nonbacterial Meningitis

Hepatocyte Growth Factor Levels in Cerebrospinal Fluid: A Comparison between Acute Bacterial and Nonbacterial Meningitis

Hepatocyte growth factor (HGF) in fecal samples: rapid detection by surface plasmon resonance

Improvement of Sepsis by Hepatocyte Growth Factor, an Anti-Inflammatory Regulator: Emerging Insights and Therapeutic Potential

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