Hepatocyte Growth Factor Levels in Cerebrospinal Fluid: A Comparison between Acute Bacterial and Nonbacterial Meningitis

Nayeri, Fariba; Nilsson, Ingela; Hagberg, Lars; Brudin, Lars; Roberg, Magnus; Söderström, Claes; Forsberg, Pia

doi:10.1086/315506

Cited by 24 publications

(24 citation statements)

References 17 publications

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“…26,27 The value was very similar to that determined in this study. It has been reported that all patients with bacterial meningitis have elevated CSF level of HGF.…”

Section: Role Of Hgf In Moyamoya Diseasesupporting

confidence: 89%

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Increased Expression of Hepatocyte Growth Factor in Cerebrospinal Fluid and Intracranial Artery in Moyamoya Disease

Nanba

Kuroda

Ishikawa

et al. 2004

Stroke

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Background and Purpose— The etiology of moyamoya disease still remains unknown. This study was aimed to explore the role of hepatocyte growth factor (HGF), a strong inducer of angiogenesis, in development of moyamoya disease. Methods— We studied cerebrospinal fluid (CSF) from 39 patients with moyamoya disease (24 children and 15 adults), 6 control patients with cervical spondylosis, and 7 control patients with internal carotid artery occlusion. CSF level of HGF was determined by enzyme-linked immunosorbent assay technique. We also evaluated the distribution of HGF and its cellular receptor c-Met in the carotid fork obtained from 2 patients with moyamoya disease and 2 control patients. Results— CSF level of HGF was 408.2±201.6 pg/mL and 443.2±193.5 pg/mL in patients with cervical spondylosis and internal carotid artery occlusion, respectively (mean±SD). On the other hand, CSF level of HGF was 820.3±319.0 pg/mL in patients with moyamoya disease, being significantly higher than those in 2 control groups ( P <0.01). Both HGF and c-Met were widely distributed in the media and thickened intima of the carotid fork in patients with moyamoya disease but not in control patients. Conclusions— This study revealed that HGF is densely found in the carotid fork, and its CSF level is markedly elevated in moyamoya disease, suggesting that HGF may be a key protein for pathogenesis of moyamoya disease.

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“…26,27 The value was very similar to that determined in this study. It has been reported that all patients with bacterial meningitis have elevated CSF level of HGF.…”

Section: Role Of Hgf In Moyamoya Diseasesupporting

confidence: 89%

“…It has been reported that all patients with bacterial meningitis have elevated CSF level of HGF. 26,27 Tsuboi et al also reported the CSF level of HGF in patients with Alzheimer disease is elevated. 28 Therefore, moyamoya disease is the third unique disease in which CSF level of HGF is differentially elevated.…”

Section: Role Of Hgf In Moyamoya Diseasementioning

confidence: 96%

Increased Expression of Hepatocyte Growth Factor in Cerebrospinal Fluid and Intracranial Artery in Moyamoya Disease

Nanba

Kuroda

Ishikawa

et al. 2004

Stroke

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“…HGF was produced in high amounts locally during injuries caused by infection and might contribute to wound healing by a paracrine effect [25,26]. HGF levels in serum decreased soon after appropriate treatment was initiated [27].…”

Section: Discussionmentioning

confidence: 99%

Hepatocyte growth factor; expression, concentration and biological activity in chronic leg ulcers

Nayeri

Olsson²,

Peterson

et al. 2005

Journal of Dermatological Science

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“…In many inflammatory diseases, including bacterial meningitis (Nayeri et al 2000), and multiple sclerosis (Kern et al 2001;Tsuboi et al 2002), serum and/or local tissue concentrations of HGF are increased. In general, HGF is thought to play a beneficial role in disease, stimulating repair mechanisms of damaged tissues.…”

Section: Introductionmentioning

confidence: 99%

Expression of the HGF receptor c‐met by macrophages in experimental autoimmune encephalomyelitis

Moransard

Sawitzky

Fontana

et al. 2009

Glia

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Hepatocyte growth factor (HGF) is a pleiotropic cytokine able to evoke a wide array of cellular responses including proliferation, migration, and survival through activation of its receptor c‐met. Various types of leukocytes have been described to express c‐met suggesting that HGF/c‐met signaling may directly influence leukocyte responses in inflammation. We have investigated the HGF/c‐met pathway in experimental autoimmune encephalomyelitis (EAE), a common mouse model of multiple sclerosis (MS), in which macrophages play a dual role, contributing directly to CNS damage at disease onset but promoting recovery during remission by removing myelin debris. Here we show that during EAE both HGF and c‐met are expressed in the CNS and that c‐met is activated. We subsequently demonstrate that c‐met is primarily expressed in inflammatory lesions by macrophages and a small number of dendritic cells (DCs) and oligodendrocyte progenitor cells (OPCs) but not by microglia or T cells. Complementary in vitro experiments show that only LPS and TNFα, but not IL‐6, IL‐10, or IL‐13, are able to induce c‐met expression in macrophages. In addition, using TNF signaling deficient macrophages we demonstrate that LPS and TNFα induce c‐met through distinct pathways. Furthermore, TNFα‐ and LPS‐induced c‐met is functional because treatment of macrophages with recombinant HGF results in rapid phosphorylation of c‐met. Interestingly, HGF/c‐met signaling does not modulate cytokine expression, phagocytosis, or antigen presentation but promotes proliferation of activated macrophages. Taken together, our data indicate a pro‐inflammatory role for the HGF/c‐met pathway in EAE rather than a role in the initiation of repair mechanisms. © 2009 Wiley‐Liss, Inc.

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Hepatocyte Growth Factor Levels in Cerebrospinal Fluid: A Comparison between Acute Bacterial and Nonbacterial Meningitis

Cited by 24 publications

References 17 publications

Increased Expression of Hepatocyte Growth Factor in Cerebrospinal Fluid and Intracranial Artery in Moyamoya Disease

Increased Expression of Hepatocyte Growth Factor in Cerebrospinal Fluid and Intracranial Artery in Moyamoya Disease

Hepatocyte growth factor; expression, concentration and biological activity in chronic leg ulcers

Expression of the HGF receptor c‐met by macrophages in experimental autoimmune encephalomyelitis

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