Effects of decontamination and implant surface characteristics on re‐osseointegration following treatment of peri‐implantitis

Parlar, Ateş; Bosshardt, Dieter D.; Çetiner, Deniz; Schafroth, Denis; Ünsal, Berrin; Haytaç, Cenk; Lang, Niklaus P.

doi:10.1111/j.1600-0501.2008.01655.x

Cited by 75 publications

(76 citation statements)

References 29 publications

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“…7 Although the final goal of the therapy is reosseointegration and bone regeneration around implants, previous studies have demonstrated that reosseointegration around diseased implants is very difficult to achieve. 8 A broad variety of different antimicrobial treatment modalities such as surgical and non-surgical approaches, chemical and mechanical decontamination, laser treatment or therapies with antiseptics or antibiotics have been proposed to achieve this goal. [9][10][11][12][13] Unfortunately, pre-vention of bacterial colonization on the micro structured dental implant surface seems to be impossible.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

Karimi¹,

Hasani²,

Khosroshahian

2016

J Lasers Med Sci

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Introduction:The purpose of the present study was to assess the clinical effects of antimicrobial photodynamic therapy (PDT) after closed surface scaling in the treatment of peri-implant diseases. Methods: Ten patients with a total of 15 pairs of dental implants, showing clinical and radiographic signs of peri-implant diseases, were included in this study. In each patient, one implant randomly served as control implant and the other served as test implant. The control implants were treated with closed surface scaling only and the test implants received additionally PDT, using light with a wavelength of 630 nm and intensity of 2000 mw/cm 2 for 120 seconds after application of photosensitizer in peri-implant sulcus. Clinical parameters were evaluated before and 1.5 and 3 months after treatment. Results: Statistical analysis showed significant differences in probing pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), and gingival index (GI) at each time point between the two groups. There were no statistically significant changes with respect to any of the parameters in the control group. Complete resolution of BOP at 3 months was achieved in 100% of test implants. At 1.5 and 3 months, there were significant differences in the mean probing depth and CAL gain measurements at implants in the test group. Conclusion: The present study revealed that adjunctive use of PDT following closed surface scaling could lead to clinical improvement of peri-implant diseases. Further studies are necessary to confirm our results. Keywords: clinical trial; dental implant; mechanical debridement; peri-implantitis; photodynamic therapy Please cite this article as follows: Karimi MR, Hasani A, Khosroshahian S. Efficacy of antimicrobial photodynamic therapy as an adjunctive to mechanical debridement in the treatment of peri-implant diseases: a randomized controlled clinical trial.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

Karimi¹,

Hasani²,

Khosroshahian

2016

J Lasers Med Sci

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“…During the progression of active peri-implantitis, acute bone resorption occurs around an implant owing to inflammatory response. Numerous bone regenerative materials and methods have been developed, and several studies have shown re-osseointegration around previously infected implants [8][9][10] . However, in most clinical situations, thin connective tissues are observed to surround the infected implants, resulting in separation from the peri-implant bone.…”

Section: Introductionmentioning

confidence: 99%

Effects of acidic sodium fluoride-treated, commercially pure titanium on periodontal pathogens and rat bone marrow cells

et al. 2014

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The purpose of the present study was to clarify the potentiality of acidic fluoride solution in treating peri-implantitis. We examined bactericidal activity of fluoride solution against periodontal pathogens; and evaluated the effects of fluoride on titanium, and the effects on cell proliferation and differentiation of rat bone marrow cells on the fluoride-treated titanium. Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis were used to determine minimal inhibitory concentration (MIC) and shorttime exposure. The cells were seeded on the titanium surface with or without fluoride treatment. Then, cellular proliferation, differentiation and mineral deposition were analyzed. The MIC values for A. actinomycetemcomitans and P. gingivalis were 225 and 900 ppm F − , respectively. In short-time exposure test, both bacterial strains exhibited a significant decrease in a concentrationdependent manner. Cell proliferation and mineral deposition were significantly increased on the fluoride-treated surface. Within the limitation of this study, acidic sodium fluoride solution has the potentiality in treating peri-implantitis.

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“…A range of therapies has been suggested for the treatment of peri-implant diseases in animals [10-18]. Air-powder abrasive units, citric acid, chlorhexidine irrigation, carbon dioxide lasers, rotating brushes with pumice, or cotton pellets soaked in saline, hydrogen peroxide, or chlorhexidine have been used alone or in various combinations.…”

Section: Introductionmentioning

confidence: 99%

In situ dental implant installation after decontamination in a previously peri-implant diseased site: a pilot study

Kim

Kook

Park

et al. 2012

J Periodontal Implant Sci

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PurposeThe aim of this study was to examine whether a previous peri-implantitis site can affect osseointegration, by comparing implant placement at a site where peri-implantitis was present and at a normal bone site. A second aim of this study was to identify the tissue and bone reaction after treating the contaminated implant surface to determine the optimal treatment for peri-implant diseases.MethodsA peri-implant mucositis model for dogs was prepared to determine the optimal treatment option for peri-implant mucositis or peri-implantitis. The implants were inserted partially to a length of 6 mm. The upper 4 mm part of the dental implants was exposed to the oral environment. Simple exposure for 2 weeks contaminated the implant surface. After 2 weeks, the implants were divided into three groups: untreated, swabbed with saline, and swabbed with H2O2. Three implants from each group were placed to the full length in the same spot. The other three implants were placed fully into newly prepared bone. After eight weeks of healing, the animals were sacrificed. Ground sections, representing the mid-buccal-lingual plane, were prepared for histological analysis. The analysis was evaluated clinically and histometrically.ResultsThe untreated implants and H2O2-swabbed implants showed gingival inflammation. Only the saline-swabbed implant group showed re-osseointegration and no gingival inflammation. There was no difference in regeneration height or bone-to-implant contact between in situ implant placement and implant placement in the new bone site.ConclusionsIt can be concluded that cleaning with saline may be effective in implant decontamination. After implant surface decontamination, implant installation in a previous peri-implant diseased site may not interfere with osseointegration.

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Effects of decontamination and implant surface characteristics on re‐osseointegration following treatment of peri‐implantitis

Abstract: Both SLA implants and in situ cleansing resulted in the best re-osseointegration and bone fill of previously contaminated implants.

Cited by 75 publications

References 29 publications

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunctive to Mechanical Debridement in the Treatment of Peri-implant Diseases: A Randomized Controlled Clinical Trial

Effects of acidic sodium fluoride-treated, commercially pure titanium on periodontal pathogens and rat bone marrow cells

In situ dental implant installation after decontamination in a previously peri-implant diseased site: a pilot study

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