EFFORTS to control murine typhus fever in the southeastern United States, although overshadowed by accomplishments in the con¬ trol of malaria, have achieved results which are almost as spectacular. An outstanding reduction of murine typhus transmission was accomplished within 25 years after the role of the rat and rat flea as host and vector of murine typhus was first suggested by Maxcy in 1926 (1) on the basis of epidemiological studies in Alabama and Georgia and validated in 1931 by Dyer, Rumreich, and Badger (#), who isolated the pathogen from fleas collected from wild rats.The introduction of DDT, an insecticide with prolonged residual toxicity, into typhus control programs in 1945 and of anticoagulant rat poison in 1947 provided the tools with which the control of murine typhus was finally ac¬ complished (fig. 1).Incidence of the disease always has been greatest in the southeastern section of the coun¬ try (fig. 2). Reported cases from 10 of the southeastern States rose from 1,799 in 1940 to 5,292 in 1944. Studies by Hill and co-workers