2016
DOI: 10.1111/apt.13687
|View full text |Cite
|
Sign up to set email alerts
|

Effects of dark chocolate on NOX‐2‐generated oxidative stress in patients with non‐alcoholic steatohepatitis

Abstract: Cocoa polyphenols exert an antioxidant activity via NOX2 down-regulation in NASH patients.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

1
22
0

Year Published

2016
2016
2021
2021

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 41 publications
(23 citation statements)
references
References 43 publications
1
22
0
Order By: Relevance
“…It seems that all the different formulations that were used in the studies, such as tablets and chocolate drinks, failed to display any significant effect. Moreover, in agreement with previous evidences in vivo ( 1 ), milk chocolate does not produce any significant antioxidant effect in humans, and it has been utilized as control ( 57 ) in the only study where an effect was detected with dark chocolate.…”
Section: Antioxidant Effect Of Chocolate In Vivosupporting
confidence: 87%
See 1 more Smart Citation
“…It seems that all the different formulations that were used in the studies, such as tablets and chocolate drinks, failed to display any significant effect. Moreover, in agreement with previous evidences in vivo ( 1 ), milk chocolate does not produce any significant antioxidant effect in humans, and it has been utilized as control ( 57 ) in the only study where an effect was detected with dark chocolate.…”
Section: Antioxidant Effect Of Chocolate In Vivosupporting
confidence: 87%
“…An increase in plasma polyphenol levels, namely, epicatechin, catechin, epicatechin-3 O -methylether, and total phenolics, following a cocoa-based product supplementation period was detected in three studies out of seven. Increases were not correlated to any changes in markers of antioxidant function except for Loffredo et al ( 57 ).…”
Section: Antioxidant Effect Of Chocolate In Vivomentioning
confidence: 90%
“…Cocoa has gained interested based on its antioxidative potential and has been found to decrease NADPH oxidase levels in NASH patients and reduce oxidative stress [ 100 , 101 ]. Similarly, cinnamon has been studied for its antioxidative effects as well and a blinded trial in NAFLD patients by Askari et al reported that 1500 mg of cinnamon supplementation for 12 weeks reduced AST, ALT, and insulin resistance compared to the placebo group [ 102 ].…”
Section: Household Herbsmentioning
confidence: 99%
“…Oxidative stress refers to a shift in the balance toward increased intracellular reactive oxygen species (ROS) generation, compared to breakdown (Mann et al, 2017). Nicotinamideadenine dinucleotide phosphate oxidase (NOX) is considered the major cellular ROS source (Loffredo et al, 2016;Long et al, 2017;Rabelo et al, 2018). Its activation has been associated with hepatic injury (Matsumoto et al, 2018;Zheng et al, 2018) and also plays a very plausible role as the starting point of extrahepatic damage, leading to inflammation and fibrosis through activation of Kupffer cells and hepatic stellate cells (HSCs) (Das et al, 2015;, thus causing a self-perpetuating circle of ROS formation and ROS-mediated damage (Masarone et al, 2018;Zhong and Liu, 2018).…”
mentioning
confidence: 99%