Effects of danazol, gonadotropin-releasing hormone agonist, and estrogen/progestogen combination on experimental endometriosis in the ovariectomized rat

Henig, Israel; Rawlins, Richard G.; Weinrib, Harry P.; Dmowski, W. Paul

doi:10.1016/s0015-0282(16)59727-1

Cited by 19 publications

(7 citation statements)

References 19 publications

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“…The wall of the cyst was composed of surface epithelium and stroma. All these components were very similar to those of normal endometrium, and these cysts resembled those produced by Jones' method (Henig et al, 1988). The protrusion of the cyst from the renal surface in the nontreated rats may be caused by an accumulation of fluid in the cystic cavity, since normal uterine epithelium secretes fluid in response to ovarian hormones.…”

Section: Discussionsupporting

confidence: 54%

“…Experimental endometriosis produced by autotransplantation of endometrium into the sub-serous membrane in the abdominal wall (peritoneal endometriosis model) has been reported in the monkey (Dizerega et al, 1980), rabbit (Schenken and Asch, 1980) and rat (Jones, 1984 ;Henig et al, 1988). In the present series of experiments, we produced experimental endometriosis in the renal subcapsular space in the rat and used this to evaluate the drugs.…”

Section: Discussionmentioning

confidence: 96%

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Histological Studies on the Therapeutic Effect of Sustained-Release Microspheres of a Potent LHRH Agonist (Leuprorelin Acetate) in an Experimental Endometriosis Model in Rats.

et al. 1990

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The therapeutic effect of sustained-release microspheres of a potent LHRH agonist (leuprorelin acetate) on experimental endometriosis in female rats was examined histologically.Endometriosis was produced in rats by autotransplantation of endometrial tissue obtained from the left uterine horn into the renal subcapsular space.In the nontreated rats, the transplants were well established and had formed large cysts containing fluid.The walls of the cysts were composed of epithelium and stroma resembling that of normal endometrium.In the rats which received the microspheres of leuprorelin acetate, growth of the transplant was markedly suppressed as evidenced by the reduced size of the cystic cavity and the flattened and pyknotic epithelium. Also, the uterine and ovarian weight decreased significantly.In the ovariectomized rats, growth of the transplant was also markedly suppressed, and the uterine weight decreased.The present results clearly indicate that a single injection of the sustainedrelease microspheres of leuprorelin acetate markedly suppresses growth of the transplant and produces uterine and ovarian atrophy in the rats.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 96%

Histological Studies on the Therapeutic Effect of Sustained-Release Microspheres of a Potent LHRH Agonist (Leuprorelin Acetate) in an Experimental Endometriosis Model in Rats.

et al. 1990

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“…5,9 The rats in the third gro up (n= 8) we re gi ven 1 mg/kg/day of ti bo lo ne (Li vi al ® tab let, Or ga non) for four we eks with ga va ge. The do se of ti bo lo ne was cal cu la ted ba sed on the re com men da ti ons by Ge naz za ni et al with the the ra pe u tic do se ran ge (0.2-2 mg/g/day) ar ran ged for fe ma le rats.…”

Section: Pha Se IImentioning

confidence: 99%

“…5 The tre at ment of en do metri o sis was in ves ti ga ted in ear li er stu di es with a rat mo del using GnRHa and go na dot ro pin re le a sing hor mo ne an ta go nists and va ri o us agents such as pen to xiphy lli ne, doxyc ycli ne, and le va mi zol. [5][6][7][8][9] GnRH ana lo gu es are be ing used ef fec ti vely in the tre at ment of en do met ri o sis and the re is a con sensus in the cur rent li te ra tu re that the se agents are ef fec ti ve. 5,9 The use of GnRHa with monthly injec ti ons or in jec ti ons with 3-month in ter vals in hibits ova ri an es tro gen synthe sis and forms a hypo es tro ge nic en vi ron ment, thus di mi nis hing the en do met ri o sis fo ci.…”

mentioning

confidence: 99%

“…[5][6][7][8][9] GnRH ana lo gu es are be ing used ef fec ti vely in the tre at ment of en do met ri o sis and the re is a con sensus in the cur rent li te ra tu re that the se agents are ef fec ti ve. 5,9 The use of GnRHa with monthly injec ti ons or in jec ti ons with 3-month in ter vals in hibits ova ri an es tro gen synthe sis and forms a hypo es tro ge nic en vi ron ment, thus di mi nis hing the en do met ri o sis fo ci. 5,10 Ti bo lo ne is a mo le cu le that has a se lec ti ve re gu la tory ef fect on the es tro gen re cep tors.…”

mentioning

confidence: 99%

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Therapeutic Efficiency of Tibolone in a Rat Endometriosis Model

Şimşek¹,

Ceyhan²,

Üstün³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : This study ai med to eva lu a te the the ra pe u tic ef fi ci ency of ti bo lo ne in an ex pe ri men tal rat mo del of in tra-ab do mi nal en do met ri o sis. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : In this ex pe rimen tal study, in tra-ab do mi nal en do met ri o sis was in du ced in 30 fe ma le rats sur gi cally. Fo ur we eks af ter this pro ce du re, la pa ro tomy was per for med again. The di men si ons of the en do met ri o sis fo ci were re cor ded and right af ter, the ope ra ti on was comp le ted. Rats we re ran domly di vi ded in to thre e gro ups and sub se qu ently, the tre at ment was star ted. In the first gro up (n= 8), a sing le do se of 1 cc 0.9% NaCl was in jec ted sub cu ta ne o usly. In the se cond gro up (n= 8), in tra mus cu lar in jec ti on of 1 mg le up ro lid ace ta te was ad mi nis te red. In the third gro up (n= 8), 1 mg/kg/day of ti bo lo ne was gi ven by ga va ge. At the end of 4-we eks of drug ad mi nis tra ti on, la pa ro tomy was per for med to all rats. The di men si ons of the en do met ri o sis fo ci we re re cor ded. Af ter wards, all the rats we re sac ri fi ced. The dif fe ren ces in the are as of en do met ri o tic imp lants and ad he si on sco res we re com pa red bet we en the gro ups. R Re e s su ul lt ts s: : The di men si ons of the en do met ri o sis fo ci in the gro ups tre a ted with le up ro lid (p< 0.05) and ti bo lo ne (p< 0.05) we re sig ni fi cantly di mi nis hed compared to that of the con trol gro up. No sta tis ti cally sig ni fi cant dif fe ren ces we re fo und bet we en the tre at ment gro ups. C Co on nc c l lu u s si i o on n: : In a rat en do met ri o sis mo del, ti bo lo ne has a si mi lar ef fi ci ency as that of le up ro lid ace ta te, an agent used for con ven ti o nal me di cal tre at ment of en do met ri o sis. With its an dro ge nic and pro ges ta ge nic charac te ris tics, ti bo lo ne de ser ves at ten ti on as an al ter na ti ve agent in the me di cal tre at ment of en domet ri o sis in hu man. K Ke ey y W Wo or rd ds s: : Rats; endometriosis; gonadotropin-releasing hormone; tibolone Ö ÖZ ZE ET T A Am ma aç ç: : Bu ça lış ma da ka rın içi en do met ri o zis li de ney sel sı çan mo de lin de ti bo lon un te ra pö tik et kin li ği nin de ğer len di ril me si amaç lan dı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Bu de ney sel ça lış ma da, 30 di şi sı çan -da ka rın içi cer ra hi en do met ri o zis mey da na ge ti ril di. Bu iş lem den dört haf ta son ra tekrar la pa ro tomi ya pıl dı. En do met ri o zis odak la rı nın bo yut la rı kay de dil di he men ar dın dan ope ras yon ta mam lan dı. Sı çan lar rast ge le üç gru ba ay rıl dı ve da ha son ra te da vi baş lan dı. Bi rin ci gru ba (n= 8), NaCl 1 cc %0.9 tek doz ola rak cilt al tı na en jek te edil di. İkin ci gru ba (n= 8), le up ro lid ase tat 1 mg in tra mus kü ler ola rak uy gu lan dı. Üçün cü gru ba (n= 8), ti bo lon 1mg/kg/gün ola rak ga vaj ile ve ril di. Dört haf ta ilaç alı mı nın son ra s...

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Endometrial Response to Hormonal Therapy

Deligdisch¹

1991

Clinical Perspectives in Obstetrics and Gynecology

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Effects of danazol, gonadotropin-releasing hormone agonist, and estrogen/progestogen combination on experimental endometriosis in the ovariectomized rat

Cited by 19 publications

References 19 publications

Histological Studies on the Therapeutic Effect of Sustained-Release Microspheres of a Potent LHRH Agonist (Leuprorelin Acetate) in an Experimental Endometriosis Model in Rats.

Histological Studies on the Therapeutic Effect of Sustained-Release Microspheres of a Potent LHRH Agonist (Leuprorelin Acetate) in an Experimental Endometriosis Model in Rats.

Therapeutic Efficiency of Tibolone in a Rat Endometriosis Model

Endometrial Response to Hormonal Therapy

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