Effects of D1 receptor agonist SKF 38393 on male rat sexual behavior and postcopulatory departure in the goal compartment–runway paradigm

Migraine and erectile dysfunction: Evidence from a population-based case-control study

“…Neurotransmitter regulation is one critical juncture in the translation of long-term steroid effects into rapid behavioural events (6), with dopamine long being known to enhance sexual motivation and copulatory behaviour (24). It is released before and during copulation in several key integrative sites, and has also long been known to facilitate masculine sexual function clinically (6).…”

Dopamine, the medial preoptic area, and male sexual behavior

“…Specifically, animals that received 7-OH-DPAT or B-HT 920, selective D 2 /D 3 DA receptor agonists, displayed higher frequencies of noncontact, or ''psychogenic'' erections in the presence of an inaccessible estrous female, when compared with rats receiving vehicle control [16]. Furthermore, SKF 38393, a D 1 DA receptor agonist, increased the number of copulatory behaviors and prolonged the time spent in a goal compartment with a sexually receptive female, suggesting that DA also facilitates sexual motivation [17].…”

Sexual performance and precontact 50-kHz ultrasonic vocalizations in WAG/Rij rats: Effects of opioid receptor treatment

“…This cannot exclude the effect of opioid receptor on PVs during acquisition of sexual experience, where drugs had an influence on the learning processes of rats which were sexually naïve at the beginning. Both NMDA and D1 receptors changed PVs during acquisition but not during performance in well-experienced males [12,23,63]. Our results have shown that a single injection of naltrexone or morphine did not change anticipatory precontact vocalizations which were established as the well-known rewarding value of sexual contact.…”

“…Postejaculatory 22-kHz vocalizations as well as the number of intromissions are changed by the activation of the dopamine receptors. The agonist of D1 receptors decreases the number of intromissions to ejaculation as well as has an influence on postejaculatory 22-kHz vocalizations although postejaculatory 22-kHz vocalizations are more strongly dependent on D2 receptor activity [63,70]. Dopamine D1 receptors are involved in the motivational effects of opioid receptor: rewarding via mu and aversive via kappa [71] mostly via changes of the cAMP level [72].…”