Sexual performance and precontact 50-kHz ultrasonic vocalizations in WAG/Rij rats: Effects of opioid receptor treatment

Bialy, Michał; Strefnel, M.; Nikolaev-Diak, Anna; Socha, Anna; Nikolaev, Evgeni; Boguszewski, Paweł M.

doi:10.1016/j.yebeh.2014.08.003

Cited by 6 publications

(5 citation statements)

References 78 publications

(92 reference statements)

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“…Opioids have ambiguous effects on postejaculatory vocalizations that are strain-dependent in rat. In the WAG/ Rij rats, morphine decreased the duration of postejaculatory 22-kHz vocalization, in Han Crl naltrexone also decreased the 22-kHz vocalization, while there was no significant effect in Sprague-Dawley rats on length 22-kHz vocalizations after ejaculation (Bialy et al, 2014). During the agonistic behavior, 5HT-1A agonists and the opioid agonist morphine decreased lUSVs, but less efficiently than an anxiolytic drug like diazepam (Vivian and Miczek, 1993a;.…”

Section: Discussionmentioning

confidence: 85%

Distinct classes of low frequency ultrasonic vocalizations in rats during sexual interactions relate to different emotional states

Bialy¹,

Podobińska²,

Barski³

et al. 2019

Acta Neurobiologiae Experimentalis

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This study examined low-frequency ultrasonic vocalizations (lUSVs) in rats during two types of sexual interactions: postejaculatory interval (PEI) and barrier-noncontact (NC) test. We report distinct classes of lUSVs that can be assigned to different emotional states; relaxation vs. frustration. Totally flat, 22-kHz calls (Class A), were observed during the relaxation state following ejaculation; characterized by immobilization or grooming during the PEI. On the other hand, two-three component lUSVs (Class B) that start at a higher frequency (45-kHz: flat, upward or short signal) and then shift to 35-23-kHz (mostly to 28-23-kHz), correspond as we assume, to arousal and frustration-active states associated with sniffing a hole or exploration during the NC test. We suggest that momentary, abrupt decreases of arousal during the frustration state correspond to Class B lUSVs. The detailed spectral analysis of the high-frequency component of two-component lUSVs is crucial for establishing the relationship between such lUSVs and the corresponding behavior and emotional states. Our studies indicate that while the two-component Class B 22-kHz lUSVs may relate to the frustration state, a single component, flat, Class A lUSV relates to the relaxation state. The results of these studies support a notion that rats emit distinct vocalization patterns, reflecting their emotional states.

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Section: Discussionmentioning

confidence: 85%

Distinct classes of low frequency ultrasonic vocalizations in rats during sexual interactions relate to different emotional states

Bialy¹,

Podobińska²,

Barski³

et al. 2019

Acta Neurobiologiae Experimentalis

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“…After ejaculation, elevated levels of serotonin and diminished levels of dopamine (Lorrain, Riolo, Matuszewich, & Hull, 1999), and both D2 receptor agonist and D1 receptor agonists, depress postejaculatory vocalizations (Beck et al, 2002; Cagiano, Barfield, White, Pleim, & Cuomo, 1989). Moreover, the rewarding value of ejaculation measured in CPP procedure depends on activation of an opioids system (Ågmo & Berenfeld, 1990), although the effect of naltrexone and morphine on 22-kHz vocalizations can be different in different strains of rats (Bialy et al, 2014). These data suggest that several different neurotransmitters systems may be involved in the 22-kHz vocalization associated with the negative versus positive emotional state.…”

Section: Discussionmentioning

confidence: 99%

Modulation of 22-khz postejaculatory vocalizations by conditioning to new place: Evidence for expression of a positive emotional state.

Bialy¹,

Bogacki-Rychlik

Kasarełło

et al. 2016

Behavioral Neuroscience

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It has been assumed that the 22-kHz ultrasonic vocalizations (USVs) are emitted by adult rats as a result of a negative emotional state. However, emission of the 22-kHz vocalizations by male rats has been also observed following ejaculation, which has a high rewarding value as shown by a conditioned place preference test. These observations suggest that 22-kHz USVs may also occur in response to a positive emotional state. The aim of this study was to determine whether the postejaculatory 22-kHz USVs are related to conditioning processes. The 22 kHz USVs were recorded in Sprague-Dawley males in the postejaculatory refractory period during conditioning processes to a new chamber unrelated to copulation. During the first session in the clean recording chamber, males vocalized marginally and exhibited intensive rearing behavior. From the second to fourth sessions, vocalization duration increased and the number of rearing decreased. Following established conditioning process, odor cues from foreign males, but not the familiar ones, resulted in decreased duration of 22-kHz USVs and increased the number of rearing. On the other hand, in the presence of mating cues (copulatory chamber and presence of the female), males exhibited increased duration of postejaculatory 22-kHz USVs and reduced number of rearing. These results demonstrated that the conditioning to the cues, both unrelated and related to copulation, is important for evoking postejaculatory 22-kHz USVs as well as the relaxation state. Furthermore, these results confirmed the postejaculatory 22-kHz USVs' involvement in expression of the positive emotional state. (PsycINFO Database Record

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“…Since sexual behavior depends on specific strain of rats, laboratory environment, nutrition and housing (Hansen et al, 1978;Bialy et al, 2014;Molenda-Figueira et al, 2017;Sanna et al, 2017), changes in specific parameters describing male sexual behavior should be evaluated against values obtained in control groups in a given experimental paradigm. Abbreviations: ACTH, adrenocorticotropic hormone; CRH, corticotropin-releasing hormone; EF, ejaculation frequency; HPG, hypothalamic-pituitary-gonadal axis; III, inter-intromission interval; PDE5, phosphodiesterase 5; PVs, precontact vocalizations in the 50-kHz band; SSRI, selective serotonin reuptake inhibitor.…”

Section: Intromission Ratiomentioning

confidence: 99%

“…Abbreviations: ACTH, adrenocorticotropic hormone; CRH, corticotropin-releasing hormone; EF, ejaculation frequency; HPG, hypothalamic-pituitary-gonadal axis; III, inter-intromission interval; PDE5, phosphodiesterase 5; PVs, precontact vocalizations in the 50-kHz band; SSRI, selective serotonin reuptake inhibitor. References in the table: [1] (Pfaus and Phillips, 1991, Van Furth et al, 1994, Barr et al, 1999; [2] (Bialy et al, 2000); [3] (Pfaus et al, 2013); [4] (Fiorino and Phillips, 1999); [5] (Novati et al, 2018); [6] (Barrot et al, 2005, Miwa et al, 2011; [7] (Pfaus and Phillips, 1991); [8] (Faulkner et al, 2015); [9] (Babaei-Balderlou and Khazali, 2016); [10] (Bialy et al, 2014); [11] (Sadeghzadeh et al, 2018); [12] (McVary et al, 1997); [13] (Hawley et al, 2013, Sanna et al, 2014; [14] (Ramírez-Rodríguez et al, 2017, Hernández andFernández-Guasti, 2018); [15] (Coolen et al, 1997, Pattij et al, 2005a, Clément et al, 2007, Kang et al, 2013, Olayo-Lortia et al, 2014; [16] (Grønli et al, 2005); [17] (de Jong et al, 2005, Hueletl-Soto et al, 2012; [18] (Coolen et al, 1997, Beck and; [19] (Harris and Sachs, 1975, Valcourt and Sachs, 1979, Novati et al...…”

Section: Intromission Ratiomentioning

confidence: 99%

“…In addition to the retarded ejaculation model described above, copulatory efficiency and sexual motivation are strongly affected by metabolic disorders, especially type 2 diabetes mellitus (McVary et al, 1997;Faulkner et al, 2015), depressivelike/anhedonic states (Pfaus and Phillips, 1991;Van Furth et al, 1994;Bialy et al, 2014), or high anxiety levels (Hawley et al, 2013;Sanna et al, 2014).…”

Section: Intromission Ratiomentioning

confidence: 99%

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The Sexual Motivation of Male Rats as a Tool in Animal Models of Human Health Disorders

Bialy

Bogacki-Rychlik

Przybylski

et al. 2019

Front. Behav. Neurosci.

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Normal or dysfunctional sexual behavior seems to be an important indicator of health or disease. Many health disorders in male patients affect sexual activity by directly causing erectile dysfunction, affecting sexual motivation, or both. Clinical evidence indicates that many diseases strongly disrupt sexual motivation and sexual performance in patients with depression, addiction, diabetes mellitus and other metabolic disturbances with obesity and diet-related factors, kidney and liver failure, circadian rhythm disorders, sleep disturbances including obstructive sleep apnea syndrome, developmental and hormonal disorders, brain damages, cardiovascular diseases, and peripheral neuropathies. Preclinical studies of these conditions often require appropriate experimental paradigms, including animal models. Male sexual behavior and motivation have been intensively investigated over the last 80 years in animal rat model. Sexual motivation can be examined using such parameters as: anticipatory behavior and 50-kHz ultrasonic vocalizations reflecting the emotional state of rats, initiation of copulation, efficiency of copulation, or techniques of classical (pavlovian) and instrumental conditioning. In this review article, we analyze the behavioral parameters that describe the sexual motivation and sexual performance of male rats in the context of animal experimental models of human health disorders. Based on analysis of the parameters describing the heterogeneous and complex structure of sexual behavior in laboratory rodents, we propose an approach that is useful for delineating distinct mechanisms affecting sexual motivation and sexual performance in selected disease states and the efficacy of therapy in preclinical investigations.

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Sexual performance and precontact 50-kHz ultrasonic vocalizations in WAG/Rij rats: Effects of opioid receptor treatment

Cited by 6 publications

References 78 publications

Distinct classes of low frequency ultrasonic vocalizations in rats during sexual interactions relate to different emotional states

Distinct classes of low frequency ultrasonic vocalizations in rats during sexual interactions relate to different emotional states

Modulation of 22-khz postejaculatory vocalizations by conditioning to new place: Evidence for expression of a positive emotional state.

The Sexual Motivation of Male Rats as a Tool in Animal Models of Human Health Disorders

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