Effects of d-Amphetamine on Temporal Control in a Peak-Interval Procedure in Lewis and Fischer 344 Rats

Follett, Meagan E.

doi:10.33915/etd.7312

Cited by 1 publication

(4 citation statements)

References 39 publications

(49 reference statements)

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“…Rather, the difference reflects a left shift of the function for LEW when compared to F344, indicating a difference in the speed of timing itself. This result conflicts somewhat with Follett (2014) and Smith et al (2015), in which LEW rats showed wider peak spread without mean shifts in the peak time, which is indicative of greater timing variability rather than differences in mean duration estimates. However, because the peak procedure does not constrain responding to a single response per trial, it may not capture the differences between LEW and F344 rats.…”

Section: Baselinecontrasting

confidence: 68%

“…administration (Follett, 2014). Results showed no differences in peak time between the two strains, though LEW rats showed higher response rates and larger peak spread in certain conditions of the experiment.…”

Section: Lewis and Fischer 344 Ratsmentioning

confidence: 71%

“…The analyses used here still uncovered strain differences between LEW and F344 along certain variables. Previous studies have also found significant strain differences between LEW and F344 using ANOVA tests with similar sample sizes (e.g., Follett, 2014;. Still, it is possible that strain differences would have emerged along additional variables with a larger sample size.…”

Section: Limitationsmentioning

confidence: 78%

“…The higher peak spread in LEW rats reflects the results of Smith et al (2015). In Follett (2014), it is possible that the larger spread may have reflected impulsive behavior in the LEW rat in the form of premature responding, as latencies to begin responding were shorter in this strain. For most rats, the shift to the left in the peak time (indicating an earlier peak time) was observed after d-AMP administration, but the extent of the shift did not differ between the LEW and F344 strains.…”

Section: Lewis and Fischer 344 Ratsmentioning

confidence: 90%

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Temporal Bisection and Effects of d-Amphetamine Administration in Lewis and Fischer 344 Rats

Turturici¹

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Temporal Bisection and Effects of d-Amphetamine Administration in Lewis and Fischer 344 Rats Marissa Turturici Temporal control concerns the discrimination of intervals of time. Individuals with various psychological disorders have shown differences in temporal control when compared to control populations. It is unknown whether and how temporal control might be linked with impulsivity, another measure that predicts problem behavior such as attention-deficit/hyperactivity disorder. Because Lewis (LEW) rats reliably show greater impulsive choice relative to Fischer 344 (F344) rats, the present study examined responding in these two strains under a temporal-bisection procedure that assesses temporal control. In the temporal-bisection procedure, rats are trained to discriminate between two durations. Intermediate durations are subsequently presented to determine the duration at which responding is nearly equally distributed between the original training durations. This duration is the bisection point. Because LEW rats show greater impulsive choice, it was hypothesized that LEW rats would show overestimation of duration (shorter bisection points). This effect would indicate that the subjective experience of duration, or delay, is longer for LEW rats. Results indicated that LEW rats' bisection points were shorter on average than F344 rats' bisection points in the baseline phase of the experiment. The baseline difference between LEW and F344 was not replicated during a subsequent phase of the experiment, but LEW and F344 rats did show differential effects of d-amphetamine on behavior during select conditions and doses. Effects of d-amphetamine replicated previous studies that showed apparent loss of stimulus control with increasing d-amphetamine doses, as opposed to underestimation or overestimation of temporal duration. The results generally add to the evidence supporting a link between impulsivity and temporal control. Nonhuman Animal Studies .

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Section: Baselinecontrasting

confidence: 68%

Section: Lewis and Fischer 344 Ratsmentioning

confidence: 71%

Section: Limitationsmentioning

confidence: 78%

Section: Lewis and Fischer 344 Ratsmentioning

confidence: 90%

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Temporal Bisection and Effects of d-Amphetamine Administration in Lewis and Fischer 344 Rats

Turturici¹

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Effects of d-Amphetamine on Temporal Control in a Peak-Interval Procedure in Lewis and Fischer 344 Rats

Abstract: In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion.

Cited by 1 publication

References 39 publications

Temporal Bisection and Effects of d-Amphetamine Administration in Lewis and Fischer 344 Rats

Temporal Bisection and Effects of d-Amphetamine Administration in Lewis and Fischer 344 Rats

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