Effects of d-amphetamine on short- and long-term memory in spontaneously hypertensive, Wistar–Kyoto and Sprague–Dawley rats

Meneses, Alfredo; Ponce-López, Teresa; Tellez, Ruth; González, Roberto; Castillo, Carlos; Gasbarri, Antonella

doi:10.1016/j.bbr.2010.08.035

Cited by 22 publications

(8 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, passively yoked cocaine delivery did not impact working memory (Harvey et al 2009; Kantak et al 2005), suggesting that the contingency of cocaine delivery is important for altering the working memory function of the prefrontal cortex. Although acute injection of amphetamine improves working memory (Meneses et al 2011), chronic injection of amphetamine neither improves nor disrupts working memory (Shoblock et al 2003), suggesting that contingency of amphetamine delivery may be a factor as well with repeated exposure. Regarding opiates, rats made dependent on morphine displayed deficits in working memory if i.p.…”

Section: Neurocognitive Deficits Associated With Abused Substancesmentioning

confidence: 99%

Cognitive enhancers for facilitating drug cue extinction: Insights from animal models

Dhonnchadha

Kantak

2011

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Given the success of cue exposure (extinction) therapy combined with a cognitive enhancer for reducing anxiety, it is anticipated that this approach will prove more efficacious than exposure therapy alone in preventing relapse in individuals with substance use disorders. Several factors may undermine the efficacy of exposure therapy for substance use disorders, but we suspect that neurocognitive impairments associated with chronic drug use are an important contributing factor. Numerous insights on these issues are gained from research using animal models of addiction. In this review, the relationship between brain sites whose learning, memory and executive functions are impaired by chronic drug use and brain sites that are important for effective drug cue extinction learning is explored first. This is followed by an overview of animal research showing improved treatment outcome for drug addiction (e.g. alcohol, amphetamine, cocaine, heroin) when explicit extinction training is conducted in combination with acute dosing of a cognitive-enhancing drug. The mechanism by which cognitive enhancers are thought to exert their benefits is by facilitating consolidation of drug cue extinction memory after activation of glutamatergic receptors. Based on the encouraging work in animals, factors that may be important for the treatment of drug addiction are considered.

show abstract

Section: Neurocognitive Deficits Associated With Abused Substancesmentioning

confidence: 99%

Cognitive enhancers for facilitating drug cue extinction: Insights from animal models

Dhonnchadha

Kantak

2011

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

show abstract

“…In adult SHR, d-amphetamine reduces hyperactivity and impulsivity, and improves sustained attention and short- and long-term memory [48,49]. However, effects of d-amphetamine in adolescent SHR are not well known.…”

Section: Introductionmentioning

confidence: 99%

Adolescent d-amphetamine treatment in a rodent model of ADHD: Pro-cognitive effects in adolescence without an impact on cocaine cue reactivity in adulthood

Jordan

Taylor

Dwoskin

et al. 2016

Behavioural Brain Research

View full text Add to dashboard Cite

Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk. Preclinical work in the Spontaneously Hypertensive Rat (SHR) model of ADHD found that adolescent methylphenidate increased cocaine self-administration in adulthood, suggesting a need to identify alternatively efficacious medications for teens with ADHD. We examined effects of adolescent d-amphetamine treatment on strategy set shifting performance during adolescence and on cocaine self-administration and reinstatement of cocaine-seeking behavior (cue reactivity) during adulthood in male SHR, Wistar-Kyoto (inbred control), and Wistar (outbred control) rats. During the set shift phase, adolescent SHR needed more trials and had a longer latency to reach criterion, made more regressive errors and trial omissions, and exhibited slower and more variable lever press reaction times. d-Amphetamine improved performance only in SHR by increasing choice accuracy and decreasing errors and latency to criterion. In adulthood, SHR self-administered more cocaine, made more cocaine-seeking responses, and took longer to extinguish lever responding than control strains. Adolescent d-amphetamine did not alter cocaine self-administration in adult rats of any strain, but reduced cocaine seeking during the first of seven reinstatement test sessions in adult SHR. These findings highlight utility of SHR in modeling cognitive dysfunction and comorbid cocaine abuse in ADHD. Unlike methylphenidate, d-amphetamine improved several aspects of flexible learning in adolescent SHR and did not increase cocaine intake or cue reactivity in adult SHR. Thus, adolescent d-amphetamine was superior to methylphenidate in this ADHD model.

show abstract

“…Behaviorally, adult SHR display impulsivity [15, 16], inattention [17, 18], working memory impairment [19, 20] and set shifting deficits [19] relative to Wistar-Kyoto (WKY) rats, the inbred comparator strain. It is important to note, however, that these behavioral deficits are not observed consistently in adult SHR [21–23].…”

Section: Introductionmentioning

confidence: 99%

Performance on a strategy set shifting task during adolescence in a genetic model of attention deficit/hyperactivity disorder: Methylphenidate vs. atomoxetine treatments

Harvey

Jordan

Tassin

et al. 2013

Behavioural Brain Research

View full text Add to dashboard Cite

Research examining medication effects on set shifting in teens with attention deficit/hyperactivity disorder (ADHD) is lacking. An animal model of ADHD may be useful for exploring this gap. The Spontaneously Hypertensive Rat (SHR) is a commonly used animal model of ADHD. SHR and two comparator strains, Wistar-Kyoto (WKY) and Wistar (WIS), were evaluated during adolescence in a strategy set shifting task under conditions of a 0-sec or 15-sec delay to reinforcer delivery. The task had three phases: initial discrimination, set shift and reversal learning. Under 0-sec delays, SHR performed as well as or better than WKY and WIS. Treatment with 0.3 mg/kg/day atomoxetine had little effect, other than to modestly increase trials to criterion during set shifting in all strains. Under 15-sec delays, SHR had longer lever press reaction times, longer latencies to criterion and more trial omissions than WKY during set shifting and reversal learning. These deficits were not reduced systematically by 1.5 mg/kg/day methylphenidate or 0.3 mg/kg/day atomoxetine. Regarding learning in SHR, methylphenidate improved initial discrimination, whereas atomoxetine improved set shifting but disrupted initial discrimination. During reversal learning, both drugs were ineffective in SHR, and atomoxetine made reaction time and trial omissions greater in WKY. Overall, WIS performance differed from SHR or WKY, depending on phase. Collectively, a genetic model of ADHD in adolescent rats revealed that neither methylphenidate nor atomoxetine mitigated all deficits in SHR during the set shifting task. Thus, methylphenidate or atomoxetine monotherapy may not mitigate all set shift task-related deficits in teens with ADHD.

show abstract

Effects of d-amphetamine on short- and long-term memory in spontaneously hypertensive, Wistar–Kyoto and Sprague–Dawley rats

Cited by 22 publications

References 61 publications

Cognitive enhancers for facilitating drug cue extinction: Insights from animal models

Cognitive enhancers for facilitating drug cue extinction: Insights from animal models

Adolescent d-amphetamine treatment in a rodent model of ADHD: Pro-cognitive effects in adolescence without an impact on cocaine cue reactivity in adulthood

Performance on a strategy set shifting task during adolescence in a genetic model of attention deficit/hyperactivity disorder: Methylphenidate vs. atomoxetine treatments

Contact Info

Product

Resources

About