Effects of d-alanine Intake on Amino Acid Metabolism and Kidney Function in Healthy Adults: A Multicenter, Randomized Pilot Study

Oshima, Megumi; Toyama, Tadashi; Toyama, Tatsuhiko; Nakade, Yusuke; Tokumaru, Toshiaki; Sako, Keisuke; Kajikawa, Sho; Hayashi, Daiki; Sanada, Hajime; Yuasa, Takahiro; Koshino, Akihiko; Horikoshi, Keisuke; Minami, Taichiro; Tsuge, Shunsuke; Tamai, Akira; Nakagawa, Shiori; Nishioka, Ryo; Zoshima, Takeshi; Ito, Kiyoaki; Kitajima, Shinji; Mizushima, Ichiro; Hara, Akinori; Sakai, Norihiko; Shimizu, Miho; Mita, Masashi; Iwata, Yasunori; Wada, Takashi

doi:10.1016/j.cdnut.2024.103787

Current Developments in Nutrition

2024

DOI: 10.1016/j.cdnut.2024.103787

|View full text |Cite

Effects of d-alanine Intake on Amino Acid Metabolism and Kidney Function in Healthy Adults: A Multicenter, Randomized Pilot Study

Megumi Oshima,

Tadashi Toyama,

Tatsuhiko Toyama

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 26 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Kinetic analysis of D-Alanine upon oral intake in humans

Kimura,

Sakai,

Horio

et al. 2024

Amino Acids

View full text Add to dashboard Cite

D-Alanine, a rare enantiomer of alanine, can potentially alleviate the worsening of viral infections and maintain circadian rhythm. This study aimed to analyze the kinetics of D-Alanine upon oral intake. Five healthy volunteers were administered D-Alanine as a single oral dose at 11,236 or 33,708 µmoL (1–3 g). Upon intake of the lower dose, the plasma level of D-Alanine reached its peak concentration of 588.4 ± 40.9 µM with a peak time of 0.60 ± 0.06 h. The compartment model estimated the clearance of D-Alanine at 12.5 ± 0.3 L/h, or 208 ± 5 mL/min, distribution volume of 8.3 ± 0.7 L and half-life of 0.46 ± 0.04 h, suggesting a rapid clearance of D-Alanine. The peak concentration and area under the curve increased proportionally upon intake of the higher dose, while the clearance, distribution volume and half-life did not. The urinary ratio of D-Alanine per sum of D- and L-Alanine reached its peak of nearly 100%, followed by a slow decline. The peak time of the urinary ratio was 1.15 ± 0.15 h, showing a time lag of blood to urine excretion. Fractional excretion, a ratio of the clearance of a substance per a standard molecule in kidney, of D-Alanine increased from 14.0 ± 5.8% to 64.5 ± 10.3%; the latter corresponded to the urinary clearance of D-Alanine as about 77 mL/min for an adult, with a peak time of 1.90 ± 0.56 h. D-Alanine was quickly absorbed and appeared in blood, followed by urinary excretion. This kinetic analysis increases our fundamental knowledge of the oral intake of D-Alanine for the chronic dosing.Trial number: #UMIN000050865.Date of registration: 2023/6/30.

show abstract

Kinetic analysis of D-Alanine upon oral intake in humans

Kimura,

Sakai,

Horio

et al. 2024

Amino Acids

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Effects of d-alanine Intake on Amino Acid Metabolism and Kidney Function in Healthy Adults: A Multicenter, Randomized Pilot Study

Cited by 1 publication

References 26 publications

Kinetic analysis of D-Alanine upon oral intake in humans

Kinetic analysis of D-Alanine upon oral intake in humans

Contact Info

Product

Resources

About