2024
DOI: 10.1007/s00726-024-03421-6
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Kinetic analysis of D-Alanine upon oral intake in humans

Tomonori Kimura,
Shinsuke Sakai,
Masaru Horio
et al.

Abstract: D-Alanine, a rare enantiomer of alanine, can potentially alleviate the worsening of viral infections and maintain circadian rhythm. This study aimed to analyze the kinetics of D-Alanine upon oral intake. Five healthy volunteers were administered D-Alanine as a single oral dose at 11,236 or 33,708 µmoL (1–3 g). Upon intake of the lower dose, the plasma level of D-Alanine reached its peak concentration of 588.4 ± 40.9 µM with a peak time of 0.60 ± 0.06 h. The compartment model estimated the clearance of D-Alanin… Show more

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