Effects of cyclic polylactate (CPL) on the growth of cloned leukemic cells in vitro

Aizawa, Shin; Shimizu, Noriaki; Handa, Hiroshi; Hara, Masaki; Hoshi, Hajime; Nagasu, M; Kanno, Hitoshi; Nagasu, Youichirou; Imanishi, Yoshio

doi:10.1002/1099-1069(200006)18:2<51::aid-hon656>3.3.co;2-g

Cited by 5 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even though some early reports on the bioactivity of cyclic oligomers can be found in the literature, [195,196] cyclo-based polymers were only really considered for biomedical applications following the work of Szoka and coworkers, in 2009. [197,198] Their study reported on the effects of the architecture on the pharmacokinetics (i.e., the fate of a substance in a living organism, including its absorption, metabolization, biodistribution, and elimination from the body) of polymers in mice.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Cyclic polymers: Advances in their synthesis, properties, and biomedical applications

Liénard

Winter

Coulembier

2020

Journal of Polymer Science

View full text Add to dashboard Cite

Since the time first synthetic macrocycles were observed as academic curiosities, great advances have been made. Thanks to the development of controlled polymerization processes, new catalytic systems and characterization techniques during the last decades, well-defined cyclic polymers are now readily accessible. This further permits the determination of their unique set of properties, mainly due to their lack of chain ends, and their use for industrial applications can now be foreshadowed. This review aims to give an overview on the recent progresses in the field of ring polymers to this day. The current state of the art of the preparation of cyclic polymers, the challenges related to it such as the purification of the samples and the scalability of the synthetic processes, the properties arising from the cyclic topology and the potential use of cyclobased polymers for biomedical applications are as many topics covered in this review.

show abstract

Section: Biomedical Applicationsmentioning

confidence: 99%

Cyclic polymers: Advances in their synthesis, properties, and biomedical applications

Liénard

Winter

Coulembier

2020

Journal of Polymer Science

View full text Add to dashboard Cite

show abstract

“…Second, our results suggest that the PLGA, PDLLA and PEG-PLGA substrates (control group) might also be effective in the inhibition of human ovarian cancer, consistent with earlier reports. 36,37 However, a combination of the TNF-a plus IFN-g with the polymers (the co-immobilized group) allows a noticeable increase of the representative flow cytometry picture of apoptotic OVCAR-3 cells, as shown in Fig. 5.…”

Section: Discussionmentioning

confidence: 99%

The apoptosis of OVCAR-3 induced by TNF-α plus IFN-γ co-immobilized polylactic acid copolymers

et al. 2012

View full text Add to dashboard Cite

“…Thus, they effectively inhibit the growth of FM3A ascites tumors (2). Other studies have also reported that an extract containing cyclic poly-L-lactates inhibited the cell growth of leukemic (3,4) and carcinoma cells (5). However, oligolactates are water-insoluble substances and require a water-miscible organic solvent such as dimethyl sulfoxide or a solubilizing agent such as a surfactant to be dissolved in water; unfortunately, these agents are generally cytotoxic or affect cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

Preparation and <i>in vitro</i> tumor growth inhibitory effect of oligo (L-lactate) nanoparticles

Matsumoto

Murao

Watanabe

et al. 2020

DD&T

View full text Add to dashboard Cite

Oligo L-lactates (oligolactates) that have low molecular weights less than 2000 have been reported to inhibit tumor growth and extend the survival of experimental animals. Because oligolactates are scarcely soluble in water, they require a solvent or a solubilizing agent, such as a surfactant, to be dissolved in water. However, these agents are generally cytotoxic, an in vitro assay appropriate to evaluate the inhibitory effect on tumor growth has not been developed yet. Here, we prepared a solid nanodispersion of oligolactates using an oil-in-water emulsion solvent evaporation method to evaluate its tumor inhibitory activity in vitro without a solvent or surfactant. Polyol solutions containing polyvinyl alcohol (PVA) were used as a continuous phase. The formation of nanoparticles depended on the concentrations of polyol and PVA in the continuous phase. The nanoparticles with a particle size of approximately 100 nm were obtained using 10-15% PVA and 60% propylene glycol. The obtained aqueous nanodispersion of oligolactates inhibited the growth of B16-BL6 melanoma cells in vitro, whereas the medium alone did not affect tumor cell growth. Therefore, oligo(L-lactate) nanoparticles may be useful in the research and development of oligolactates as a remedy for cancer.

show abstract

Effects of cyclic polylactate (CPL) on the growth of cloned leukemic cells in vitro

Cited by 5 publications

References 0 publications

Cyclic polymers: Advances in their synthesis, properties, and biomedical applications

Cyclic polymers: Advances in their synthesis, properties, and biomedical applications

The apoptosis of OVCAR-3 induced by TNF-α plus IFN-γ co-immobilized polylactic acid copolymers

Preparation and <i>in vitro</i> tumor growth inhibitory effect of oligo (L-lactate) nanoparticles

Contact Info

Product

Resources

About