The apoptosis of OVCAR-3 induced by TNF-α plus IFN-γ co-immobilized polylactic acid copolymers

Design of magnetic nanoparticles for hepatocellular carcinoma treatment using the control mechanisms of the cell internal nucleus and external membrane

“…In summary, we have demonstrated that for HepG2 cells treated with the OA-MNPs-III drug, remarkable changes in the cell morphology and mortality, specific cell cycle G 1 arrest, and inapparent caspase-3 (8,9) expression are observed. These facts allow one to argue that an additional caspase-independent cell death pathway (oncosis), in concert with caspase-dependent apoptosis pathway (apoptosis), may cause more remarkable death of HepG2.…”

“…Trans arterial chemoembolization (TACE) is considered as the mainstay of palliative treatment for unresectable HCC. [6][7][8][9][10][11][12] Moreover, nanoparticle drugs and associated treatment technologies have been receiving widespread attention. However, the efficacy of TACE is limited due to the lack of tumor targeting, which results in many drawbacks such as attacking liver cells, plugging blood vessels, and damage to the hepatic artery.…”

“…5 Subsequently, our testing on HeLa, OVCAR-3, and MCF-7 cells unveiled that the co-immobilization of TNF-a (tumor necrosis factor-a)/ IFN-g (interferon-g) biomaterials (based on polystyrene, polyurethane, polylactic acid copolymers) have potential for treating some types of carcinomas for women by alternate cancer cell death mechanisms. [6][7][8][9][10][11][12] Moreover, nanoparticle drugs and associated treatment technologies have been receiving widespread attention. [13][14][15][16] Among the targeting nanometer drugs, magnetic nanoparticles (MNPs, including r2-Fe 2 O 3 , Me-Fe 2 O 3 , Fe 3 O 4 , NiCo-Fe, FeCo and NiFe alloy) covered with effective anti-tumor molecules, the so-called magnetic nanoparticle drugs, offer physical therapy advantages over others, such as small particle size, large specific surface, high capacity coupling, and magnetic response, which allow possibilities to overcome the drawbacks of traditional administrations.…”

Effects of Differentiation and Antisenescence from BMSCs to Hepatocy-Like Cells of the PAAm-IGF-1/TNF-α Biomaterial

“…The photochemical surface modification has been well demonstrated to be efficient and highly preferred, − not only for functional activity consideration but also for its biological compatibility. In our earlier works, − we developed various approaches of photoimmobilization to fix TNF-α/IFN-γ onto polystyrene, polyurethane, and other biomaterials. This technique was proved simple and efficient, and consequently, a series of investigations on the human gynecologic cancer HeLa, OVCAR-3, and/or MCF-7 cells death regulations were carried out.…”