Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens

Steinkellner, Hans; Rabot, Sylvie; Freywald, Christian; Nobis, Eva; Scharf, Gerlinde; Chabicovsky, Monika; Knasmüller, Siegfried; Kassie, Fekadu

doi:10.1016/s0027-5107(01)00188-9

Cited by 163 publications

(84 citation statements)

References 60 publications

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“…Both fruits and vegetables contain many substances that might decrease the mutagenic activity of HCAs. For instance, breakdown products from cruciferous vegetables can affect enzymes involved in the metabolism of HCAs 61 , and flavonoids in onions, citrus fruits, apples, etc. may decrease the formation of HCA-DNA adducts 62 .…”

Section: Discussionmentioning

confidence: 99%

Dietary intake of heterocyclic amines in relation to socio-economic, lifestyle and other dietary factors: estimates in a Swedish population

Ericson

Wirfält

Mattisson

et al. 2007

Public Health Nutr.

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Objectives: To estimate the dietary intakes of heterocyclic amines (HCAs), to examine the intakes in relation to socio-economics, lifestyle and other dietary factors and to compare the classification of subjects by intake of HCA versus intake of meat and fish. Design: Cross-sectional analysis within the Malmö Diet and Cancer (MDC) cohort. Data were obtained from a modified diet history, a structured questionnaire on socioeconomics and lifestyle, anthropometric measurements and chemical analysis of HCAs. HCA intake was cross-classified against meat and fish intake. The likelihood of being a high consumer of HCAs was estimated by logistic regression analysis. Dietary intakes were examined across quintiles of HCA intake using analysis of variance. Setting: Baseline examinations conducted in 1991-1994 in Malmö, Sweden. Subjects: A sub-sample of 8599 women and 6575 men of the MDC cohort. Results: The mean daily HCA intake was 583 ng for women and 821 ng for men. Subjects were ranked differently with respect to HCA intake compared with intake of fried and baked meat and fish (k ¼ 0.13). High HCA intake was significantly associated with lower age, overweight, sedentary lifestyle and smoking. Intakes of dietary fibre, fruits and fermented milk products were negatively associated with HCA intake, while intakes of selenium, vegetables, potatoes, alcohol (among men) and non-milk-based margarines (among women) were positively associated with HCA intake. Conclusions: The estimated daily HCA intake of 690 ng is similar to values obtained elsewhere. The present study suggests that lifestyle factors (e.g. smoking, physical activity, fruit and vegetable intakes, and types of milk products and margarines) may confound associations between HCA intake and disease. The poor correlation between HCA intake and intakes of fried meat and fish facilitates an isolation of the health effects of HCAs. Keywords Heterocyclic aminesSocio-economics Lifestyle Nutrients Foods Cohort study Epidemiological studies have indicated that diet is an important factor in the global variation of human cancer rates and the importance of dietary components for cancer development has been generally accepted. Doll and Peto estimated in 1981 that 10 -70% of all cancer in the USA could be related to diet 1 . The mutagenic/carcinogenic heterocyclic amines (HCAs) in cooked foods have been discussed in the aetiology of human cancer 2 . The first report on high mutagenic activity in cooked meat appeared almost 30 years ago 3,4 ; since then much research has been devoted to studying various aspects of HCAs, such as their formation, occurrence in foods, levels of exposure, metabolism, dietary factors that influence their uptake and biotransformation, and hereditary factors that influence the metabolism of these dietary carcinogens 5 .The molecular structures of two of the most abundant HCAs,quinoxaline) and PhIP (2-amino-1-methyl-6-phenylimidazo [4,5-b ]pyridine), are shown in Fig. 1.HCAs are absorbed and metabolised by humans; urinary metabolites of HCAs have...

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Section: Discussionmentioning

confidence: 99%

Dietary intake of heterocyclic amines in relation to socio-economic, lifestyle and other dietary factors: estimates in a Swedish population

Ericson

Wirfält

Mattisson

et al. 2007

Public Health Nutr.

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“…CVs, especially those of the Brassica variety, have been shown to display several anticarcinogenic properties in vivo, as reviewed by Steinkellner et al (10) with the various underlying mechanisms having been summarized by others (11). Some of these mechanisms include alterations in the activities of metabolic enzymes (12), resulting in reduced carcinogenicity of dietary or environmental carcinogens in vivo (13), reduction of oxidative DNA damage levels in humans after supplementation with Brussels sprouts (14), and reduced DNA damage in human lymphocytes ex vivo in conditions of increased oxidative stress after supplementation with cruciferous and leguminous sprouts (15).…”

Section: Introductionmentioning

confidence: 99%

Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults

Gill

Haldar

Boyd

et al. 2007

The American Journal of Clinical Nutrition

142

113

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“…Besides, it is believed that fruits and vegetables are rich in antioxidants and they can have a protective role against cancer (7,8). Cruciferous vegetables can protect humans against cancer, and studies on animals have shown that these vegetables can reduce chemically induced tumor formation (9). It was shown that reactive oxygen species (ROS) can modulate various physiological processes such as the regulation of growth factor signaling, the hypoxic response, the inflammatory process, and the immune response in mammalian cells (10).…”

Section: Introductionmentioning

confidence: 99%

Investigating Lifestyle and Dietary Style in Patients with Lymphoma of the Head and Neck Admitted to Razi Hospital in the City of Rasht

2018

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Background: In recent years, the incidence of various types of cancer including lymphoma has been on the rise. Although there have been developments in terms of knowledge of its biology and treatments, its etiology is still less known. In this respect, lifestyle and dietary factors can play important roles in the etiology of lymphoma. Thus, the purpose of the present study was to investigate the lifestyle and the dietary style in patients with lymphoma of the head and neck. Methods: This study was a retrospective case-control research. The patient group (57 people) was selected from the department of oncology at Razi hospital in the city of Rasht and the control group (57 individuals) was selected out of healthy individuals referred to Guilan school of dentistry. Then, both groups completed questionnaires concerning the research variables. After collecting the required information, the data were entered into the SPSS Software (version 21) to evaluate the dietary style and the lifestyle in the both groups. Results: Comparing the lifestyle in both study groups, the rate of smoking (P < 0.0001) as well as the body mass index (BMI) (P = 0.0001) in the patient group was higher than those in the control group. Moreover, comparing the dietary style in both groups showed that the rates of red meat intake (P = 0.005) in the patient group, and the consumption of fresh herbs (P = 0.009) and fruits (P = 0.043) in the control group were high. These differences were also statistically significant. Conclusions:The consumption of red meat, herbs, and fruit, as well as the body mass index were considered as predictors of lymphoma. Furthermore, smoking was directly correlated with the incidence of lymphoma.

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Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens

Cited by 163 publications

References 60 publications

Dietary intake of heterocyclic amines in relation to socio-economic, lifestyle and other dietary factors: estimates in a Swedish population

Dietary intake of heterocyclic amines in relation to socio-economic, lifestyle and other dietary factors: estimates in a Swedish population

Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults

Investigating Lifestyle and Dietary Style in Patients with Lymphoma of the Head and Neck Admitted to Razi Hospital in the City of Rasht

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