Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride

Yang, Xu; Xu, Feibo; Zhuang, Cuicui; Bai, Chongsheng; Huang, Wanyue; Song, Miao; Han, Yaling; Li, Yanfei

doi:10.1007/s12011-016-0678-3

Cited by 4 publications

(2 citation statements)

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“…Reasonable correlations were found among the predicted IR, Raman and UV spectra with the corresponding experimental ones [56]. The calculations of gap values [54] and some descriptors were performed, as suggested by Parr and Pearson [59][60][61][62][63][64][65][66][67][68], because the prediction of reactivities and behaviours in the three media are of interest for this hormone with anti-inflammatory and immunosuppressive properties [20,21,23,27,[30][31][32][35][36][37][39][40][41][42][43][44].…”

Section: Methodsmentioning

confidence: 99%

“…The IUPAC name of corticosterone is (11β)-11,21-dihydroxypregn-4-ene-3,20-dione although it is also known as 11β,21-dihydroxyprogesterone or simply as 17-deoxycortisol . The adrenal gland produces this hormone with antiinflammatory and immunosuppressive properties [20,21,23,27,[30][31][32][35][36][37][39][40][41][42][43][44]. So far, there are a lot of articles related to structural, chemical and biological studies on glucocorticoids, from experimental studies by using spectroscopic and electrochemical techniques up to different theoretical studies because these species present dual regulation effects on the immune function which are strongly dependent on the concentration.…”

Section: Introductionmentioning

confidence: 99%

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Investigating the behaviors of corticosterone hormone in different solvents by using DFT calculations and experimental data

2019

Biointerface Res Appl Chem

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In this work, structural, electronic, topological and vibrational properties of corticosterone hormone have been investigated in aqueous, ethanol and methanol solutions by using DFT calculations and experimental available infrared, attenuated total reﬂectance (ATR), Raman and Ultraviolet spectra. The properties predicted in the different solvents at the B3LYP/6-31G* level of theory were compared with those obtained in gas phase and, with others reported for steroids species at the same level of theory. The universal solvation model has evidenced higher solvation energy for corticosterone in aqueous solution and a higher value in methanol, as compared with the corresponding values to equilenin, equilin and estrone steroids in the same medium. Higher Mulliken charges on O atoms of C=O group of side chain are observed in the three solvents than the corresponding to C=O group of ring A while the MK charges on O atoms of OH group of ring C present higher values than the corresponding to O atoms of OH group of side chain. The natural bond orbital (NBO) studies have revealed a low stability of corticosterone in aqueous solution, as compared with the values in ethanol and methanol solutions, in total agreement with the higher solvation energy and dipole moment in this medium. On the other hand, the atoms in molecules (AIM) analyses support the lower stabilities of corticosterone in the three solutions because only five H bonds interactions different from of gas phase where six interactions are observed. The gap values suggests that corticosterone is most reactive in aqueous solution than the other solutions, as supported by the low stability and higher solvation energy and dipole moment values in this medium. This study shows clearly that the steroid species most reactive, equilenin and corticosterone, are characterized by a high global electrophilicity index value and low nucleophilicity index. Reasonable correlations in the predicted IR, Raman and UV spectra were observed, as compared with the corresponding experimental ones. Additionally, the complete vibrational assignments of all 159-vibration modes of corticosterone together with the harmonic force fields and force constants in the different media are for the first time presented.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigating the behaviors of corticosterone hormone in different solvents by using DFT calculations and experimental data

2019

Biointerface Res Appl Chem

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The Improvement of Immune Effect of Recombinant Human Beta-Defensin 2 on Hepatitis B Vaccine in Mice

et al. 2021

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Hygienic assessment of aluminum intake in the adult population of Western Siberia

Brusentsova,

Turchaninov,

Gogadze

et al. 2024

Ekologiya cheloveka (Human Ecology)

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Aim Hygienic assessment of the dietary intake of aluminum in the body of the adult population of the region of Western Siberia. Materials methods The studies were conducted in 2019-2020 among the adult population of the Omsk region. The aluminum content in the human body was evaluated in 240 people.The actual intake of aluminum with food products was assessed in 421 adult residents of the region using a questionnaire on the frequency of food consumption. Results In 33.13.9% of the population, the content of aluminum in the body was higher than the reference values. Significant differences in the content of aluminum in the body of the population of different age-sex groups have not been determined (p=0.200). The median daily intake of aluminum was 4.77 mg/day. (3.679; 6.118). The main contribution to the intake of aluminum with food products was made by: "Drinks", "Vegetables", "Bakery products", among individual products - tea and bread. An increase in the contribution of vegetables and a decrease in the contribution of confectionery products to the intake of aluminum with an increase in the age of the population was noted. Discussion The median intake of "edible" aluminum in the adult population of the Omsk region did not exceed TWI, as well as PTWI, and corresponded to world data on the average level of aluminum intake into the human body. Conclusion An increase in the proportion of the population with a high content of aluminum in the body requires in-depth toxicological, hygienic and epidemiological studies.

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Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride

Cited by 4 publications

References 47 publications

Investigating the behaviors of corticosterone hormone in different solvents by using DFT calculations and experimental data

Investigating the behaviors of corticosterone hormone in different solvents by using DFT calculations and experimental data

The Improvement of Immune Effect of Recombinant Human Beta-Defensin 2 on Hepatitis B Vaccine in Mice

Hygienic assessment of aluminum intake in the adult population of Western Siberia

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