Effects of Corticosteroid and Electroacupuncture on Experimental Spinal Cord Injury in Dogs

Yang, Jung Whan; Jeong, Seong Mok; Seo, Kwang-Suk; Nam, Tchi Chou

doi:10.4142/jvs.2003.4.1.97

Cited by 32 publications

(28 citation statements)

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“…Of 3 placebo‐controlled experimental studies in dogs that investigated MPSS, 1 failed to show benefit and 2 showed benefit . Of the 2 that showed benefit, 1 used a very different glucocorticoid dosing regimen that combined dexamethasone and low dose MPSS and the other initiated MPSS treatment (30 mg/kg q6h for 6 doses) 48 hours after injury . However, there were no data presented on study power, and blinding and randomization were not consistently performed.…”

Section: Discussionmentioning

confidence: 99%

“…37,38 Of the 2 that showed benefit, 1 used a very different glucocorticoid dosing regimen that combined dexamethasone and low dose MPSS 37 and the other initiated MPSS treatment (30 mg/kg q6h for 6 doses) 48 hours after injury. 38 However, there were no data presented on study power, and blinding and randomization were not consistently performed. Given the experimental evidence that there may be benefit in dogs, testing MPSS rigorously in clinical cases was indicated.…”

Section: Discussionmentioning

confidence: 99%

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A Placebo‐Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation

Olby

Muguet-Chanoit

Lim

et al. 2015

Veterinary Internal Medicne

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BackgroundAcute intervertebral disk herniation (IVDH) is a common cause of spinal cord injury in dogs and currently there is no proven medical treatment to counter secondary injury effects. Use of methylprednisolone sodium succinate (MPSS) or polyethylene glycol (PEG) as neuroprotectants is advocated but controversial because neither treatment has been tested in placebo‐controlled, randomized, blinded trials in dogs.HypothesisPolyethylene glycol will improve the outcome of severe spinal cord injury caused by IVDH compared to MPSS or placebo.AnimalsClient‐owned dogs with acute onset of thoracolumbar IVDH causing paralysis and loss of nociception for <24 hours.MethodsDogs were randomized to receive MPSS, PEG, or placebo; drugs appeared identical and group allocation was masked. Drug administration was initiated once the diagnosis of IVDH was confirmed and all dogs underwent hemilaminectomy. Neurologic function was assessed 2, 4, 8, and 12 weeks postoperatively using an open field gait score (OFS) as the primary outcome measure. Outcomes were compared by the Wilcoxon rank sum test.ResultsSixty‐three dogs were recruited and 47.6% recovered ambulation. 17.5% developed progressive myelomalacia but there was no association with group. There was no difference in OFS among groups. Although full study power was not reached, conditional power analyses indicated the futility of continued case recruitment.ConclusionsThis clinical trial did not show a benefit of either MPSS or PEG in the treatment of acute, severe thoracolumbar IVDH when used as adjunctive medical treatment administered to dogs presenting within 24 hours of onset of paralysis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Placebo‐Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation

Olby

Muguet-Chanoit

Lim

et al. 2015

Veterinary Internal Medicne

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“…In the necropsy of the cat, excessive scar tissue that was compressing the spinal cord was not identified. Prednisolone treatment may improve clinical signs, as occurred in the cat, possibly by reducing inflammatory reaction and edema in the compressed spinal cord [17]. Later, despite the prednisolon treatment, the neurological status of the cat deteriorated, likely because the slowly increasing compression of the spinal cord caused degeneration of the nerve fibers and myelin sheaths.…”

Section: Discussionmentioning

confidence: 99%

Spinal dural ossification causing neurological signs in a cat

Antila¹,

Jeserevics²,

Rakauskas³

et al. 2013

Acta Vet Scand

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A six-year-old Ragdoll cat underwent examination due to a six-month history of slowly progressive gait abnormalities. The cat presented with an ambulatory tetraparesis with a neurological examination indicating a C1-T2 myelopathy. Radiographs of the spine showed a radiopaque irregular line ventrally in the vertebral canal dorsal to vertebral bodies C3-C5. In this area, magnetic resonance imaging revealed an intradural extramedullary/extradural lesion compressing the spinal cord. The spinal cord was surgically decompressed. The cause of the spinal cord compression was dural ossification, a diagnosis confirmed by histopathological examination of the surgically dissected sample of dura mater. The cat gradually improved after the procedure and was ambulating better than prior to the surgery. The cat’s locomotion later worsened again due to ossified plaques in the dura causing spinal cord compression on the same cervical area as before. Oral prednisolone treatment provided temporary remission. Ten months after surgery, the cat was euthanized due to severe worsening of gait abnormalities, non-ambulatory tetraparesis. Necropsy confirmed spinal cord compression and secondary degenerative changes in the spinal cord on cervical and lumbar areas caused by dural ossification. To our knowledge, this is the first report of spinal dural ossification in a cat. The reported cat showed neurological signs associated with these dural changes. Dural ossification should be considered in the differential diagnosis of compressive spinal cord disorders in cats.

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“…Due to differences in hindlimb functional assessments, the type of injury models used and other experimental variables, no definitive conclusions could be reached (Means et al, 1981). Later studies (Demopoulos et al, 1982; Anderson et al, 1985; Braughler et al, 1987; Young et al, 1988; Yang et al, 2003) provided more consistent demonstrations of neuroprotective effects.…”

Section: Special Design Considerations For Acute/subacute Preclinicalmentioning

confidence: 92%

Translational spinal cord injury research

Reier

Lane

Hall

et al. 2012

Handbook of Clinical Neurology

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Effects of Corticosteroid and Electroacupuncture on Experimental Spinal Cord Injury in Dogs

Cited by 32 publications

References 0 publications

A Placebo‐Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation

A Placebo‐Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation

Spinal dural ossification causing neurological signs in a cat

Translational spinal cord injury research

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