Effects of corneal thickness on the intraocular penetration of travoprost 0.004%

Martinez-de-la-Casa, José M.; Rayward, Omar; Saenz-Frances, Federico; Santos-Bueso, E.; Méndez-Hernández, Carmen; Herrero-Vanrell, Rocı́o; García‐Feijoó, Julián; García–Sánchez, J.

doi:10.1038/eye.2012.74

Cited by 6 publications

(5 citation statements)

References 20 publications

(18 reference statements)

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“…The lack of relationship found between the concentration of citicoline and CCT (R 2 = 0.14, p = 0.15) indicates that the thickness of the central cornea is not playing a significant role in the penetration of this molecule inside the eye. These results agree with previous works in which the relationship between CCT and the intraocular penetration of drugs in topical eye-drop formulation was explored [28,29].…”

Section: Discussionsupporting

confidence: 92%

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Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution

et al. 2019

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PurposeTo evaluate the presence and concentration of citicoline and its metabolites (choline, cytidine and uridine) in the vitreous body in human eyes after topical application of an ophthalmic solution of citicoline 2%, in vivo.MethodsTwenty-one subjects affected by epiretinal membrane with surgical indication for pars-plana vitrectomy underwent treatment with 1 drop 3 times/day of a solution of citicoline 2%, 0.2% high molecular weight hyaluronic acid and 0.01% benzalkonium chloride (OMK1, Omikron Italia s.r.l., Rome, Italy) 14 days before surgery and 2 hours prior to surgery. Five additional patients served as controls and received an OMK1 vehicle solution without citicoline. The vitreous samples were taken at the beginning of the pars-plana vitrectomy and analyzed for qualitative/quantitative determination of vitreous concentration of citicoline and its metabolites by means of high performance liquid chromatography.ResultsThe overall mean concentration of citicoline in patients treated with citicoline 2% solution was 406.72 ± 52.99 μg/mL, while the mean concentration of choline, cytidine and uridine was 180.88 ± 41.49 μg/mL, 44.45 ± 10.19 μg/mL and 330.41 ± 75.8 μg/mL, respectively. The concentration of citicoline in phakic eyes (n = 13, 366.61 ± 129.61 μg/mL) was lower compared to that found in pseudophakic eyes (n = 8, 435.89 ± 131.42 μg/mL) and the difference was not statistically significant. The concentration of citicoline in the control eyes was 45.66 ± 26.36 μg/mL, while the concentration of choline, cytidine and uridine were 17.21 ± 9.93 μg/mL, 6.24 ± 3.6 μg/mL and 172.80 ± 99.76 μg/mL, respectively.ConclusionCiticoline can reach the human vitreous in high concentration when administered in ophthalmic solution. This evidence contributes to the build-up of the pyramid of the evidences required for determining the role of citicoline administered in ophthalmic formulation in retinal and optic nerve neurodegenerative diseases.

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Section: Discussionsupporting

confidence: 92%

“…In a study by Martinez-de-la-Casa et al three groups of 20 patients each scheduled for cataract surgery were selected according to CCT (between 510 μm and 575 μm) and received one drop of 0.004% travoprost two hours before surgery [29]. A sample of humour aqueous was obtained performing a paracentesis with a 23G needle and was analysed.…”

Section: Discussionmentioning

confidence: 99%

Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution

et al. 2019

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“…Brandt et al reported that this reduced response to treatment is more obvious with PGAs than by BB [109]. However, no association was shown between ocular penetration of travoprost and CCT [110]. This study is limited by short-term exposure though; therefore, it cannot report on the effects of chronic use on corneal permeability.…”

Section: Response To Treatmentmentioning

confidence: 73%

The thick and thin of the central corneal thickness in glaucoma

Belovay

Goldberg

2018

Eye

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Central corneal thickness (CCT) is an important parameter in the assessment of any potential glaucoma patient. While it affects prognosis in ocular hypertension, its value in patients diagnosed with glaucoma is less certain. There are several biological factors and genetic components that may influence glaucoma progression, which have been associated with thinner CCT. The CCT itself can be affected by several factors including ethnicity, age, sex, glaucoma medications, genetics, and the subtype of glaucoma. Besides, there is variability in the measurement of CCT between difference types of devices. These factors need to be considered in the evaluation of glaucoma patients' CCT and its effect on interpretation of intraocular pressure levels and risk stratification.

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“…Corneal endothelial cell density showed similar results. Several clinical studies have reported no significant correlation between the corneal thickness and drug concentration in the aqueous humor [ 35 , 36 ]. A positive correlation was reported between corneal thickness and timolol concentration in the aqueous humor, but the correlation was weak [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Patient Factors Influencing Intraocular Penetration of Brimonidine-Related Eye Drops in Adults: A Post Hoc Pooled Analysis

Kunikane,

Orii,

Inoue

et al. 2023

Ophthalmol Ther

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Introduction:The factors related to the ocular penetration of drugs after the administration of eye drops in humans have not been examined in detail. Therefore, this study assessed the influence of patient factors on the intraocular penetration of eye drops. Methods: A pooled analysis was performed on the data of 42 participants from three studies to evaluate the ocular pharmacokinetics in humans after the topical application of brimonidine-related eye drops. The patients were scheduled for vitrectomy and received brimonidine-related eye drops (0.1% brimonidine tartrate ophthalmic solution, 0.1% brimonidine tartrate and 0.5% timolol fixed-combination ophthalmic solution, or 0.1% brimonidine tartrate and 1% brinzolamide fixed-combination suspension) twice daily for 1 week. We analyzed the effects of patient factors (sex, the presence or absence of lens, age, corneal thickness,

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Effects of corneal thickness on the intraocular penetration of travoprost 0.004%

Cited by 6 publications

References 20 publications

Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution

Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution

The thick and thin of the central corneal thickness in glaucoma

Patient Factors Influencing Intraocular Penetration of Brimonidine-Related Eye Drops in Adults: A Post Hoc Pooled Analysis

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