Effects of Copper Oxide Nanoparticles on Antioxidant Enzyme Activities and on Tissue Accumulation of Oreochromis niloticus

Tunçsoy, Mustafa; Duran, Servet; Ay, Özcan; Cıcık, Bedii; Erdem, Cahit

doi:10.1007/s00128-017-2129-z

Cited by 34 publications

(11 citation statements)

References 15 publications

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“…Moreover, Nile tilapia can be regarded as a well-established fish model for toxicological studies because of its simple handling, maintenance under laboratory conditions, and prompt response to pollutants and various toxicants [35,36]. Reports showed that the exposure of Nile tilapia to CuONPs caused oxidative stress damage [37,38], histopathological alterations [39], higher accumulation of copper in the liver [40], haemato-biochemical changes [41], and alterations of liver and kidney functions [42].…”

Section: Introductionmentioning

confidence: 99%

Copper Oxide Nanoparticles Alter Serum Biochemical Indices, Induce Histopathological Alterations, and Modulate Transcription of Cytokines, HSP70, and Oxidative Stress Genes in Oreochromis niloticus

Abdel‐Latif

Dawood

Mahmoud

et al. 2021

Animals

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In the present study, fish were exposed to sub-lethal doses of CuONPs (68.92 ± 3.49 nm) (10 mg/L, 20 mg/L, and 50 mg/L) for a long exposure period (25 days). Compared to the control group (0.0 mg/L CuONPs), a significant dose-dependent elevation in blood urea and creatinine values, serum alanine transaminase, aspartate transaminase, and alkaline phosphatase enzyme activities were evident in CuONPs-exposed groups (p < 0.05). Fish exposure to 50 mg/L CuONPs significantly upregulated the transcription of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, interleukin 12, and interleukin 8), heat shock protein 70, apoptosis-related gene (caspase 3), and oxidative stress-related (superoxide dismutase, catalase, and glutathione peroxidase) genes in liver and gills of the exposed fish in comparison with those in the control group (p < 0.05). Moreover, varying histopathological injuries were noticed in the hepatopancreatic tissues, posterior kidneys, and gills of fish groups correlated to the tested exposure dose of CuONPs. In summary, our results provide new insights and helpful information for better understanding the mechanisms of CuONPs toxicity in Nile tilapia at hematological, molecular levels, and tissue levels.

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Section: Introductionmentioning

confidence: 99%

Copper Oxide Nanoparticles Alter Serum Biochemical Indices, Induce Histopathological Alterations, and Modulate Transcription of Cytokines, HSP70, and Oxidative Stress Genes in Oreochromis niloticus

Abdel‐Latif

Dawood

Mahmoud

et al. 2021

Animals

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“…Thus, depending on different biomarkers has become a valuable tool to track environmental stressors and their effects on aquatic biota (Abdel-Khalek 2015a; Canli et al 2018). Metals may accumulate in fish tissues by direct contact via gills and dermal exposure or by absorption in the digestive tract of fish (Tunçsoy et al 2017). Therefore, the bioaccumulative metal pattern is a relative metal measurement taken by all ways that represent external influences on metal bioavailability (Abdel-Khalek et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Assessment of metal pollution impacts on Tilapia zillii and Mugil cephalus inhabiting Qaroun and Wadi El-Rayan lakes, Egypt, using integrated biomarkers

Abdel-Khalek

Zayed

El-Sayad

et al. 2020

Environ Sci Pollut Res

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Qaroun and Wadi El-Rayan lakes are exposed to a huge amount of discharges from different sources and numerous anthropogenic activities. Therefore, the present work aimed to evaluate the impacts of metal pollution on two wild fish species; Tilapia zillii and Mugil cephalus collected from lake Qaroun (eastern and western parts) and Wadi El-Rayan lakes (upper and lower lakes). Accumulation of metals (Cu, Zn, Cd, and Pb) in water, sediment, and five vital tissues as well as metal pollution index (MPI), contamination factor (CF), and pollution load index (PLI) were integrated as metal pollution biomarkers. Generally, these integrated endpoints had the same trend and indicated that the eastern part of lake Qaroun was the most polluted site followed by the lower lake of Wadi El-Rayan. To assess the environmental genotoxicity, the percentage DNA damage in different tissues of both fish species was estimated using the comet assay technique. The percentage of DNA damages showed tissue-, species-and site-specification. Hazard index (HI) has been used as an evaluation index for human health associated with fish consumption at the studied sites. This index showed that all metals were in the safe limits at normal consumption levels while adverse health effects are expected to occur at the subsistence consumption level. The safe HI for each metal at normal consumption level does not neglect that the combined cumulative risk impact of all metals is a sign of warning and the health of fish consumers nearby contaminated sites is threatened.

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“…% Inhibition = 100-100 × (GGT with NPs /GGT without NPs). (1) Several studies revealed the effects of copper oxide nanoparticles on tissue accumulation and antioxidant enzymes of Galleria Mellonella L. [30] and Oreochromis niloticus [31]. The previous study of Kojouri et al indicated the beneficial effects of Se NPs on antioxidant activity and weight gain patterns of newborn lambs which may promote lambs' growth rate in the postnatal period [32].…”

Section: Effect Of Cuo and Se Nanoparticles On Gamma-glutamyl Transferase Activitymentioning

confidence: 99%

Impact of Copper Oxide and Selenium Nanoparticles on the Activities of Myeloperoxidase and Gamma-Glutamyl Transferase Related Oxidative Stress of Myocardial Infarction Patients

Ahmed¹,

Hussain²,

Abdulsattar³

2021

Nano BioMed ENG

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Nanomedicine has tremendous prospects for the improvement of the diagnosis and treatment of human diseases. Nanotechnology has the potential to revolutionize a wide array of tools in biotechnology so that they are more personalized, portable, cheaper, safer and easier to administer. The present study aims to study the impact of copper oxide and selenium nanoparticles on the oxidative stress in sera of myocardial infraction patients through the synthesis and characterization of copper oxide and selenium nanoparticles, and the evaluation of the status of oxidative stress in sera of myocardial infraction patients through measurement of the activities of myeloperoxidase and gammaglutamyl transferase in the presence and absence of nanoparticles in sera of myocardial infraction patients. Cupric oxide nanoparticles and selenium nanoparticles have been prepared by a chemical method and by laser ablation method respectively, and have been characterized. The result indicated that copper oxide (grain shapes with the average size 30 -80 nm) and selenium nanoparticles (rodshaped structures with the average size 70 -90 nm) had an inhibition effects on myeloperoxidase and gamma-glutamyl transferase activities, and as a result had an inhibition effects on oxidative stress.

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Effects of Copper Oxide Nanoparticles on Antioxidant Enzyme Activities and on Tissue Accumulation of Oreochromis niloticus

Cited by 34 publications

References 15 publications

Copper Oxide Nanoparticles Alter Serum Biochemical Indices, Induce Histopathological Alterations, and Modulate Transcription of Cytokines, HSP70, and Oxidative Stress Genes in Oreochromis niloticus

Copper Oxide Nanoparticles Alter Serum Biochemical Indices, Induce Histopathological Alterations, and Modulate Transcription of Cytokines, HSP70, and Oxidative Stress Genes in Oreochromis niloticus

Assessment of metal pollution impacts on Tilapia zillii and Mugil cephalus inhabiting Qaroun and Wadi El-Rayan lakes, Egypt, using integrated biomarkers

Impact of Copper Oxide and Selenium Nanoparticles on the Activities of Myeloperoxidase and Gamma-Glutamyl Transferase Related Oxidative Stress of Myocardial Infarction Patients

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