Effects of Continuous Positive Airway Pressure on Diaphragm Dimensions in Preterm Infants

Rehan, Virender K.; Laiprasert, Joann; Nakashima, James M.; Wallach, Michael; McCool, F. Dennis

doi:10.1038/sj.jp.7210587

Cited by 25 publications

(22 citation statements)

References 27 publications

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“…Rehan et al. demonstrated a direct correlation between an increase in PEEP and oxygen saturation, and in the present, it was kept constant in the same infant in the different decubitus positions.…”

Section: Discussionsupporting

confidence: 57%

Effect of body position on preterm newborns receiving continuous positive airway pressure

Brunherotti

Martinez

2013

Acta Paediatrica

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Section: Discussionsupporting

confidence: 57%

Effect of body position on preterm newborns receiving continuous positive airway pressure

Brunherotti

Martinez

2013

Acta Paediatrica

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“…This pressure helps recruit alveoli and increase functional residual lung capacity [12], thus lowering the baby's work of breathing. The result is better compliance, reduced airway resistance, conservation of surfactant, and stabilized chest and diaphragm [13]. Bubble CPAP has been used in developed countries for decades [8].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a Low-Cost Bubble CPAP System in Treatment of Respiratory Distress in a Neonatal Ward in Malawi

et al. 2014

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BackgroundRespiratory failure is a leading cause of neonatal mortality in the developing world. Bubble continuous positive airway pressure (bCPAP) is a safe, effective intervention for infants with respiratory distress and is widely used in developed countries. Because of its high cost, bCPAP is not widely utilized in low-resource settings. We evaluated the performance of a new bCPAP system to treat severe respiratory distress in a low resource setting, comparing it to nasal oxygen therapy, the current standard of care.MethodsWe conducted a non-randomized convenience sample study to test the efficacy of a low-cost bCPAP system treating newborns with severe respiratory distress in the neonatal ward of Queen Elizabeth Central Hospital, in Blantyre, Malawi. Neonates weighing >1,000 g and presenting with severe respiratory distress who fulfilled inclusion criteria received nasal bCPAP if a device was available; if not, they received standard care. Clinical assessments were made during treatment and outcomes compared for the two groups.Findings87 neonates (62 bCPAP, 25 controls) were recruited. Survival rate for neonates receiving bCPAP was 71.0% (44/62) compared with 44.0% (11/25) for controls. 65.5% (19/29) of very low birth weight neonates receiving bCPAP survived to discharge compared to 15.4% (1/13) of controls. 64.6% (31/48) of neonates with respiratory distress syndrome (RDS) receiving bCPAP survived to discharge, compared to 23.5% (4/17) of controls. 61.5% (16/26) of neonates with sepsis receiving bCPAP survived to discharge, while none of the seven neonates with sepsis in the control group survived.InterpretationUse of a low-cost bCPAP system to treat neonatal respiratory distress resulted in 27% absolute improvement in survival. The beneficial effect was greater for neonates with very low birth weight, RDS, or sepsis. Implementing appropriate bCPAP devices could reduce neonatal mortality in developing countries.

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“…They have found that as CPAP was increased from low to high levels, diaphragm thickness increased significantly both at end-expiratory and at end-inspiratory lung volumes, whereas diaphragm excursion decreased at high level of CPAP, suggesting that the application of CPAP may impair diaphragm function. 22 No previous study has utilized ultrasonography to evaluate diaphragmatic thickness and excursion during nHFT therapy. The aim of our study is to compare the effect of nCPAP and nHFT on diaphragmatic dimensions and excursion as assessed by bedside ultrasonography in preterm infants (with gestational age of more than 27 weeks).…”

mentioning

confidence: 99%

Comparative Study of the Effects of Continuous Positive Airway Pressure and Nasal High-Flow Therapy on Diaphragmatic Dimensions in Preterm Infants

et al. 2017

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Effects of Continuous Positive Airway Pressure on Diaphragm Dimensions in Preterm Infants

Cited by 25 publications

References 27 publications

Effect of body position on preterm newborns receiving continuous positive airway pressure

Effect of body position on preterm newborns receiving continuous positive airway pressure

Efficacy of a Low-Cost Bubble CPAP System in Treatment of Respiratory Distress in a Neonatal Ward in Malawi

Comparative Study of the Effects of Continuous Positive Airway Pressure and Nasal High-Flow Therapy on Diaphragmatic Dimensions in Preterm Infants

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