Effects of continual intermittent administration of parathyroid hormone on implant stability in the presence of osteoporosis: an in vivo study using resonance frequency analysis in a rabbit model

Abstract

Objective:This study aimed to evaluate the effects of continual intermittent administration of parathyroid hormone (PTH) on implant stability in the presence of osteoporosis, using rabbit models.Material and Methods:Fifteen female New Zealand white rabbits underwent ovariectomy and were administered glucocorticoids to induce osteoporosis, following which they were divided into three groups. The first group received intermittent subcutaneous PTH for 4 weeks until implant placement (PTH1), while the second and third groups received PTH (PTH2) and saline (control), respectively, for 4 weeks before and after implant placement. After intermittent administration of PTH or saline, titanium implants were inserted into the left femoral epiphyses of all animals, and the implant stability quotient (ISQ) was measured immediately after placement to assess the primary stability and at 2 and 4 weeks after implant placement to assess osseointegration. At 4 weeks after implant placement, histological and histomorphometric evaluations were conducted and the bone area around the implant socket was measured as a ratio of the total bone area to the total tissue area.Results:Regarding primary stability, the ISQ values for the PTH1 and PTH2 groups were significantly higher than those for the control group (p<0.05). Concerning osseointegration, the ISQ values at 2 and 4 weeks were significantly higher for the PTH2 group than for the PTH1 and control (p<0.05) groups. Histological assessments showed a thicker and more trabecular bone around the implant sockets in the PTH2 specimens than in the PTH1 and control specimens. The bone area around the implant socket was significantly greater in the PTH2 group than in the PTH1 and control groups (p<0.05).Conclusions:Our results suggest that continual intermittent PTH administration before and after dental implant placement is effective for the achievement of favorable stability and osseointegration in the presence of osteoporosis.

Histological and Bone Morphometric Evaluation of Osseointegration Aspects by Alkali Hydrothermally-Treated Implants

“…The RT reflects a quantitative assessment of osseointegration of the entire implant. RT is strongly influenced by cortical bone integration and is strongly correlated with the BIC ratio [31][32][33]. According to the BIC and The RT measurements, the alkali group obtained excellent implant stability by achieving favorable osteointegration in the cortical bone portion.…”

Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone

“…Several studies have therefore aimed to improve depreciated bone mass and bone quality using PTH administration 16,17 . PTH increases bone mass and improves its structural characteristics, and is expected to increase the availability of dental implant treatment and enable stable osseointegration after dental implant surgery 16,17 . However, the effect of PTH administration on the material characteristics of newly formed bone in the jaw is currently unclear.…”

Surgical treatment with dental implants in a patient with secondary loss of teeth and osteoporosis caused by an imbalance of vitamin D

“…Oki et al investigated the effects of continual intermittent influence of PTH on dental implant stability in the presence of osteoporosis, using rabbit models and creating artificial osteoporosis with the use of PTH in different forms before and after implantation. 15 The authors measured the implant stability coefficient immediately and after 2 and 4 weeks. According to a histological study, the quality and quantity of bone around dental implants were better in the groups of animals with adequate compensating therapy for osteoporosis.…”