Effects of Commonly Used Topical Antimicrobial Agents on<i>Acinetobacter baumannii</i>: An In Vitro Study

Davis, Stephen C.; Pisanni, Franco; Montero, Ramon B.

doi:10.7205/milmed-d-16-00289

Cited by 2 publications

(6 citation statements)

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Section: Wound Microbiology and Wound Sampling Methodsmentioning

confidence: 99%

“…24 A. baumannii is a non-fermentative Gram-negative pathogen that is ubiquitous in nature and/ or inanimate surfaces and can colonize on healthy skin for long periods of time. 25 Despite its low human carrier rate, A. baumannii can easily spread from infected patients via transmission of aerosols and thus survive in hospital environments for days. 26 From Table 1, bacteria culture analysis had revealed that P. aeruginosa and S. aureus are the most common aerobic pathogens majorly isolated in high percentages from surgical wounds, burn wounds and chronic wounds such as diabetic foot ulcers and chronic leg ulcers.…”

Section: Wound Microbiologymentioning

confidence: 99%

“…27 These infected wounds will then develop into non healing chronic wounds, leading to septicaemia and eventually death. 25,[27][28][29] Meanwhile, bacterial pathogens that thrive in deeper layers of the wound, away from the epidermis layer, tend to be anaerobic in nature (Fig. 2).…”

Section: Wound Microbiologymentioning

confidence: 99%

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Detecting bacterial infections in wounds: a review of biosensors and wearable sensors in comparison with conventional laboratory methods

Salleh

Tanaka

Sutarlie

2022

Analyst

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Section: Wound Microbiology and Wound Sampling Methodsmentioning

confidence: 99%

Section: Wound Microbiologymentioning

confidence: 99%

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Detecting bacterial infections in wounds: a review of biosensors and wearable sensors in comparison with conventional laboratory methods

Salleh

Tanaka

Sutarlie

2022

Analyst

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“…In our in vitro studies, we measured the zones of inhibition (ZOI) using a modified Kirby‐Bauer method. This test provides adequate data to determine the testing agent's potency by measuring the diffusion within the medium against the pathogen 22,23 . The treatments were challenged under two different concentration levels of the inoculum MRSA USA300 in the in vitro analysis to simulate wounds that may be slightly or highly colonised.…”

Section: Introductionmentioning

confidence: 99%

“…This test provides adequate data to determine the testing agent's potency by measuring the diffusion within the medium against the pathogen. 22,23 The treatments were challenged under two different concentration levels of the inoculum MRSA USA300 in the in vitro analysis to simulate wounds that may be slightly or highly colonised. Further, the persistence of the antimicrobial activity of…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial effectiveness of wound matrices containing native extracellular matrix with polyhexamethylene biguanide

Davis

Gil

Solis

et al. 2021

International Wound Journal

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A variety of wound matrix materials that are designed to help heal both acute and chronic wounds are currently available. Because wounds often encounter opportunistic microbes that can delay healing, the effectiveness of these materials is often suboptimal, resulting in delayed or compromised wound healing. The importance of reducing and controlling wound microbes is well recognised and there are several antimicrobial options available to address this unmet clinical need. This study compares the antimicrobial and wound healing capabilities, both in vivo and in vitro against methicillin‐resistant Staphylococcus aureus (MRSA) USA 300, for the following compounds: Collagen Wound Matrix‐Anti Microbial (CWM‐AM); Collagen Wound Matrix‐Anti Microbial XT (CWM‐AM XT); Antimicrobial Hydrofiber Wound Dressing (AHWD); Dermal Scaffold with Silver (DRSAg); Collagen Extracellular Matrix (CEM); Collagen Wound Matrix (CWM); Matrix Wound Dressing with Silver (MWDAg); Cadexomer Iodine Gel (CIG); Triple Antibiotic Ointment (TAO); and Antimicrobial Wound Gel (AWG). For the in vitro zone of inhibition assay, AWG and CIG had the largest diffused areas, followed by CWM‐AM and CWM‐AM XT. Furthermore, CWM‐AM, CWM‐AM XT, AWG, and CIG exhibited a persistent antimicrobial activity for up to 10 days after incubation. However, in the cytotoxicity studies performed using human fibroblasts, CWM‐AM and CWM‐AM XT had no detrimental effects in cell proliferation and viability, while AWG and CIG were cytotoxic and prohibitive for cell proliferation. Treatments were then assessed for microbiology and wound healing efficacy using an in vivo porcine deep reticular dermal wound model. CWM‐AM XT displayed the greatest in vivo antimicrobial activity against MRSA USA300 and expedited the reepithelialisation at a faster rate than other treatment groups. This study shows that a novel collagen matrix containing an antimicrobial agent can reduce the bacterial load and support healing.

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Effects of Commonly Used Topical Antimicrobial Agents onAcinetobacter baumannii: An In Vitro Study

Cited by 2 publications

References 0 publications

Detecting bacterial infections in wounds: a review of biosensors and wearable sensors in comparison with conventional laboratory methods

Detecting bacterial infections in wounds: a review of biosensors and wearable sensors in comparison with conventional laboratory methods

Antimicrobial effectiveness of wound matrices containing native extracellular matrix with polyhexamethylene biguanide

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