Effects of combined Chinese drugs and chemotherapy in treating advanced non-small cell lung cancer

Chen, Yan-zhi; Li, Zhandong; Gao, Fei; Zhang, Ying; Sun, Hong; Li, Pingping

doi:10.1007/s11655-009-0415-2

Cited by 40 publications

(33 citation statements)

References 4 publications

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“…SMI had no significant impact on the ADR and PTX concentrations in the heart, liver and other tissues (Figure 3). In accordance with our results, SMI seems to be generally safe for clinical use [4,6,8,18] . Many studies have found that the synergistic effects of SMI or its main components, ginseng saponins, with chemotherapeutic agents were due to the influence on multiple cancer signaling pathways, such as NF-κB, JNK, MAPK, p53, among others [19,20] .…”

Section: Discussionsupporting

confidence: 92%

“…Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution eral malignancy types, including lung cancer [6] , liver cancer [7] , breast cancer [8] and gastric cancer [9] . However, most studies have focused on improving the immune function of cancer patients and decreasing the side effects of chemotherapy.…”

Section: Original Articlementioning

confidence: 99%

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Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution

et al. 2016

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Shenmai injection (SMI) is a Chinese patent-protected injection, which was mainly made of Red Ginseng and Radix Ophiopogonis and widely used for treating coronary heart disease and tumors by boosting Qi and nourishing Yin. In this study we examined whether SMI could produce direct synergetic effects on the cytoxicity of adriamycin (ADR) and paclitaxel (PTX) in colorectal cancers in vivo and in vitro, and explored the underlying pharmacokinetic mechanisms. BALB/c nude mice with LoVo colon cancer xenografts were intraperitoneally injected with ADR (2 mg·kg -1 ·3d -1 ) or PTX (7.5 mg·kg -1 ·3d -1 ) with or without SMI (0.01 mL·g -1 ·d -1 ) for 13 d. Co-administration of SMI significantly enhanced the chemotherapeutic efficacy of ADR and PTX, whereas administration of SMI alone at the given dosage did not produce visible anti-cancer effects, The chemosensitizing action of SMI was associated with increased concentrations of ADR and PTX in the plasma and tumors. In Caco-2 and LoVo cells in vitro, co-treatment with SMI (2 μL/mL) significantly enhanced the cytotoxicity of ADR and PTX, and resulted in some favorable pharmacokinetic changes in the subcellular distribution of ADR and PTX. In addition, SMI-induced intracellular accumulation of ADR was closely correlated with the increased expression levels of P-glycoprotein in 4 colon cancer cell lines (r 2 =+0.8558). SMI enhances the anti-cancer effects of ADR and PTX in colon cancers in vivo and in vitro by improving the subcellular distributions of ADR and PTX.

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Section: Discussionsupporting

confidence: 92%

Section: Original Articlementioning

confidence: 99%

Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution

et al. 2016

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“…Cell proliferation was assessed using a commercially available MTT kit (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (Sigma, St Louis, MO, USA) as described previously. 31 To detect apoptosis, DU145 cells were incubated in 500 ml of a binding buffer containing of FITC-conjugated annexin V (Clontech Laboratories Inc., Palo Alto, CA, USA) and propidium iodide (PI) at room temperature for 15 min. The samples were then centrifuged at 1000g for 10 min.…”

Section: Construction Of Recombinant Plasmidsmentioning

confidence: 99%

Plasmid-based Survivin shRNA and GRIM-19 carried by attenuated Salmonella suppresses tumor cell growth

Liu

Zhang²,

Guo³

et al. 2012

Asian J Androl

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Persistent activation of Survivin and its overexpression contribute to the formation, progression and metastasis of several different tumor types. Therefore, Survivin is an ideal target for RNA interference mediated-growth inhibition. Blockade of Survivin using specific short hairpin RNAs (shRNA) can significantly reduce prostate tumor growth. RNA interference does not fully ablate target gene expression, owing to the idiosyncrasies associated with shRNAs and their targets. To enhance the therapeutic efficacy of Survivin-specific shRNA, we employed a combinatorial expression of Survivin-specific shRNA and gene associated with retinoid-interferon-induced mortality-19 (GRIM-19). Then, the GRIM-19 coding sequences and Survivin-specific shRNAs were used to create a dual expression plasmid vector and were carried by an attenuated strain of Salmonella enteric serovar typhimurium (S. typhimurium) to treat prostate cancer in vitro and in vivo. We found that the co-expressed Survivin-specific shRNA and GRIM-19 synergistically and more effectively inhibited prostate tumor proliferation and survival, when compared with treatment with either single agent alone in vitro and in vivo. This study has provided a novel cancer gene therapeutic approach for prostate cancer.

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“…Patients can benefit from maintenance chemotherapy or targeted therapy, but side effects and lesser qol might limit such approaches. Recent studies have reported that, combined with platinum-based chemotherapy, some chms show superiority in relieving symptoms for lung cancer patients, mitigating the severe aes of standard cancer therapy, enhancing short-term efficacy, and improving qol [43][44][45] . In our study, performance status as evaluated by the kps was significantly improved in patients who received oral chm-based maintenance treatment (p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Oral Chinese Herbal Medicine as Maintenance Treatment after Chemotherapy for Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

Wang

Jiao

et al. 2017

Current Oncology

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Effects of combined Chinese drugs and chemotherapy in treating advanced non-small cell lung cancer

Abstract: Combined Chinese drugs and chemotherapy can enhance the short-term therapeutic efficacy in the treatment of NSCLC and prolong patients' median survival time, but show no evident impact on TTP.

Cited by 40 publications

References 4 publications

Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution

Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution

Plasmid-based Survivin shRNA and GRIM-19 carried by attenuated Salmonella suppresses tumor cell growth

Oral Chinese Herbal Medicine as Maintenance Treatment after Chemotherapy for Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

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