Effects of collagen peptides from skate (<i>Raja kenojei</i>) skin on improvements of the insulin signaling pathway <i>via</i> attenuation of oxidative stress and inflammation

Woo, Minji; Seol, Bo Gyeong; Kang, Keon-Hee; Choi, Yung Hyun; Cho, Eun Ju; Noh, Jeong Sook

doi:10.1039/c9fo02667c

Cited by 27 publications

(29 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Marine‐based collagen scaffold has applications in bone (TE), [ 74–76 ] wound healing, [ 77 ] food, and nutraceuticals and nutricosmetic. [ 78–82 ]…”

Section: Source Of Collagenmentioning

confidence: 99%

Bioprinting of Collagen: Considerations, Potentials, and Applications

Lee

Suen

Ng³

et al. 2020

Macromolecular Bioscience

View full text Add to dashboard Cite

Collagen is the most abundant extracellular matrix protein that is widely used in tissue engineering (TE). There is little research done on printing pure collagen. To understand the bottlenecks in printing pure collagen, it is imperative to understand collagen from a bottom‐up approach. Here it is aimed to provide a comprehensive overview of collagen printing, where collagen assembly in vivo and the various sources of collagen available for TE application are first understood. Next, the current printing technologies and strategy for printing collagen‐based materials are highlighted. Considerations and key challenges faced in collagen printing are identified. Finally, the key research areas that would enhance the functionality of printed collagen are presented.

show abstract

“…Marine‐based collagen scaffold has applications in bone (TE), [ 74–76 ] wound healing, [ 77 ] food, and nutraceuticals and nutricosmetic. [ 78–82 ]…”

Section: Source Of Collagenmentioning

confidence: 99%

Bioprinting of Collagen: Considerations, Potentials, and Applications

Lee

Suen

Ng³

et al. 2020

Macromolecular Bioscience

View full text Add to dashboard Cite

show abstract

“…Other studies have shown the anti‐hyperglycemic effect to be even more pronounced in a chronic setting, with the lowest dose used being 100 mg kg −1 bodyweight. [ 41,48,68,87 ] Furthermore, all in vivo studies investigating the satiating effect of FPH have shown a decrease in bodyweight or a reduction in weight gain. [ 39,65,66,88 ] These findings are very encouraging, given the wide methodological variation between studies discussed previously.…”

Section: Discussionmentioning

confidence: 99%

“…[ 94,95 ] A trial involving skate skin also showed a reduction in bodyweight and fat mass. [ 87 ] Generally speaking, human trials involving FPH have been reasonably successful with the exception of results from a single cod protein hydrolysate.…”

Section: Discussionmentioning

confidence: 99%

A Narrative Review of the Anti‐Hyperglycemic and Satiating Effects of Fish Protein Hydrolysates and Their Bioactive Peptides

Sharkey

Harnedy‐Rothwell

Allsopp

et al. 2020

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Prevalence of type 2 diabetes and overweight/obesity are increasing globally. Food supplementation as a preventative option has become an attractive option in comparison to increased pharmacotherapy dependency. Hydrolysates of fish processing waste and by-products have become particularly interesting in a climate of increased food wastage awareness and are rapidly gaining traction in food research. This review summarizes the available research so far on the potential effect of these hydrolysates on diabetes and appetite suppression. Scopus and Web of Science are searched using eight keywords (fish, hydrolysate, peptides, satiating, insulinotropic, incretin, anti-obesity, DPP-4 [dipeptidylpeptidase-4/IV]) returning a total of 2549 results. Following exclusion criteria (repeated appearances, non-fish marine sources [e.g., macroalgae], and irrelevant bioactivities [e.g., immunomodulatory, anti-thrombotic]), 44 relevant publications are included in this review. Stimulation of hormone secretion, regulation of glucose uptake, anorexigenic potential, identified mechanisms of action, and research conducted on the most potent bioactive peptides identified within these hydrolysates are all specifically addressed. Results of this review conclude that despite wide methodological variation between studies, there is significant potential for the application of fish protein hydrolysates in the management of bodyweight and hyperglycemia.

show abstract

“…Therefore, the Keap1/Nrf2‐ARE pathway is the main target for studying the mechanism of oxidative damage and screening antioxidant drugs (Cuadrado et al., 2019; Mimura & Itoh, 2015). It was demonstrated that the antioxidant peptides, curcumin, and L‐carnitine could activate the Keap1/Nrf2‐ARE pathway, reducing the oxidative damage of liver cells (Chan et al., 2018; Woo et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Magnolol of 20 mg/kg increased the levels of p‐PI3K and Nrf2 by about three times in the liver of alcohol‐induced mice, suggesting that it could prevent liver damage by activating PI3K/Nrf2 signaling pathways (X. Liu et al., 2019). The collagen peptides obtained from skate skin ( Raja kenojei ) could protect the liver from injury by increasing the antioxidative status via PI3K/AKT and Nrf2/ARE signaling pathways (Woo et al., 2020). The MAPKs mainly include extracellular regulated protein kinases (ERK), c‐Jun N‐terminal kinase (JNK), and p38, all which related to inflammation, apoptosis, and growth.…”

Section: Introductionmentioning

confidence: 99%

Collagen peptides from Acaudina molpadioides prevent CCl₄‐induced liver injury via Keap1/Nrf2‐ARE, PI3K/AKT, and MAPKs pathways

Lin

et al. 2022

Journal of Food Science

View full text Add to dashboard Cite

Collagen peptide from Acaudina molpadioides (AMP) showed antioxidative activity in H2O2‐induced RAW264.7 cells in our pervious study. In this study, it was observed that AMP could effectively improve the morphology and function of liver in CCl4‐induced mice. After 200 mg/kg AMP treatment, the content of MDA in liver decreased by 62.3%, and the level of antioxidant enzymes (SOD, GSH‐Px, and CAT) increased by more than 65%. Western blot results disclosed that AMP (200 mg/kg) upregulated the Nrf2 level by 73.8% and downregulated Keap1 by 41.0% in CCl4‐induced mice liver. The levels of p‐ERK, p‐JNK, and p‐p38 in 200 mg/kg AMP treatment groups decreased by 57.3%, 40.9%, and 40.6%, but the levels of p‐PI3K and p‐AKT increased by 162.6% and 60.3%, respectively. Furthermore, the trends of Nrf2, Keap1, p‐ERK, p‐JNK, p‐p38, p‐PI3K, and p‐AKT levels in H2O2‐induced RAW264.7 cells after AMP treatment were similar to the results in CCl4‐induced mice liver. These findings provided evidence that AMP exerted antioxidant activity via Keap1/Nrf2‐ARE, PI3K/AKT, and MAPKs pathways in vivo and in vitro. Therefore, the collagen peptide from A. molpadioides might represent a novel functional food to prevent acute liver injury via attenuation of oxidative stress.

show abstract

Effects of collagen peptides from skate (Raja kenojei) skin on improvements of the insulin signaling pathway via attenuation of oxidative stress and inflammation

Abstract: It has been well established that hepatic insulin signaling is significantly affected by the antioxidative status of the liver.

Cited by 27 publications

References 39 publications

Bioprinting of Collagen: Considerations, Potentials, and Applications

Bioprinting of Collagen: Considerations, Potentials, and Applications

A Narrative Review of the Anti‐Hyperglycemic and Satiating Effects of Fish Protein Hydrolysates and Their Bioactive Peptides

Collagen peptides from Acaudina molpadioides prevent CCl₄‐induced liver injury via Keap1/Nrf2‐ARE, PI3K/AKT, and MAPKs pathways

Contact Info

Product

Resources

About

Effects of collagen peptides from skate (Raja kenojei) skin on improvements of the insulin signaling pathway via attenuation of oxidative stress and inflammation

Abstract: It has been well established that hepatic insulin signaling is significantly affected by the antioxidative status of the liver.

Cited by 27 publications

References 39 publications

Bioprinting of Collagen: Considerations, Potentials, and Applications

Bioprinting of Collagen: Considerations, Potentials, and Applications

A Narrative Review of the Anti‐Hyperglycemic and Satiating Effects of Fish Protein Hydrolysates and Their Bioactive Peptides

Collagen peptides from Acaudina molpadioides prevent CCl4‐induced liver injury via Keap1/Nrf2‐ARE, PI3K/AKT, and MAPKs pathways

Contact Info

Product

Resources

About

Collagen peptides from Acaudina molpadioides prevent CCl₄‐induced liver injury via Keap1/Nrf2‐ARE, PI3K/AKT, and MAPKs pathways