Effects of Collagen and Collagen Hydrolysate from Jellyfish (Rhopilema esculentum) on Mice Skin Photoaging Induced by UV Irradiation

Abstract

Collagen (JC) was extracted from jellyfish (Rhopilema esculentum) and hydrolyzed to prepare collagen hydrolysate (JCH). The protective effects of JC and JCH against UV-induced damages to mice skin were evaluated and compared in this article. JC and JCH could alleviate the UV-induced abnormal changes of antioxidative indicators, including the superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities and the contents of glutathione (GSH) and malondiaidehyde (MDA). JC and JCH could protect skin lipid and collagen from the UV radiation damages. Furthermore, the changes of total ceramide and glycosaminoglycan in skin were recovered significantly by JC and JCH. The action mechanisms mainly involved the antioxidative properties and the repairing to endogenous collagen synthesis of JC and JCH in vivo. JCH with the lower molecular weight showed much higher effects than JC. The results indicated that JCH was a novel antiphotoaging agent from natural resources.

Antioxidant activity of the giant jellyfish Nemopilema�nomurai measured by the oxygen radical absorbance capacity and hydroxyl radical averting capacity methods

“…Zhuang et al reported that the collagen from Rhopilema esculentum alleviated the UV-induced abnormal changes of antioxidative indicators, including superoxide dismutase, glutathione peroxidase and catalase activities, on mouse skin (17). Although the Nemopilema nomurai jellyfish stings workers harvesting the medusae and induces cutaneous symptoms in humans, there is no significant incidence of symptoms by ingestion (18).…”

A dietary supplement improves age-related dermatological changes. Observational, anecdotal, spontaneous study.

“…24 Collagen was added into the formula since experimental evidences from murine models has shown that: if adequately orally administered it prevents UV radiationinduced skin damage. 35,36 In a study by Proksch et al, oral supplementation of collagen hydrolysate composed of specific collagen peptides (2.5 g/d or 5.0 g/d for 8 weeks) increased skin elasticity in middle-aged women after 4 weeks of supplementation. 37 Previous studies confirmed that collagen hydrolysate is degraded to small peptides by the gastrointestinal tract, that appear later in the blood stream and reach the skin in 8 up to 96 hours.…”

Antimicrobial and radical scavenging properties of bovine collagen hydrolysates produced by Penicillium aurantiogriseum URM 4622 collagenase

“…Collagen peptides were reported to affect lipid absorption and metabolism in rats (Saito et al 2009), to reduce proinflammatory cytokine production in mice (Zhuang et al 2009 Antimicrobial and radical scavenging properties of bovine collagen hydrolysates produced by Penicillium aurantiogriseum URM 4622 collagenase and to improve bone mineral density in osteoporotic rats (Beynen et al 2010) and joint disease in dogs (WatanabeKamiyama et al 2010). Recently, some collagen peptides were reported to act protectively against ultraviolet radiation-induced damage on mice skin (Zhuang et al 2009).…”