Effects of coffee ingestion on oral glucose tolerance curves in normal human subjects

Feinberg, Leonard; Sandberg, Herschel; Castro, Oscar De; Bellet, Samuel

doi:10.1016/0026-0495(68)90158-3

Cited by 49 publications

(17 citation statements)

References 29 publications

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“…43 However, a number of experimental studies addressed this issue by adding the experimental dose of caffeine to decaffeinated coffee or by using coffee itself. [9][10][11][12][13]16,17,19,25,27 The results of these studies are similar to those that presented pure caffeine in capsules, with both kinds of treatments leading to insulin resistance or impaired glucose tolerance. Although at least one study found that the effects of caffeine administered in decaffeinated coffee were smaller than those of caffeine alone, 13 evidence from all studies suggests that coffee has effects similar to pure caffeine.…”

Section: Relevance Of the Experimental Results To Understanding The Csupporting

confidence: 78%

“…Glucose and insulin responses can also be combined to calculate an estimate of whole-body insulin sensitivity, the insulin sensitivity index (ISI). 24 Of the 14 studies that used this challenge protocol, [9][10][11][12][13][14][15][16][17][18][19][20][21][22] all but one 9 found evidence of insulin resistance after caffeine administration, compared to placebo control. Insulin responses (area under the curve) were significantly larger after caffeine, indicating that more insulin was required to dispose of the glucose.…”

Section: Caffeine Effects On Insulin Resistancementioning

confidence: 99%

“…At least 17 studies [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] were published between 1968 and 2010 describing the effects of caffeine on glucose metabolism in healthy nondiabetic adults. These studies used doubleblind and placebo-controlled experimental designs.…”

Section: Caffeine Effects On Insulin Resistancementioning

confidence: 99%

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Caffeine, Glucose Metabolism, and Type 2 Diabetes

Lane

2011

Journal of Caffeine Research

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Type 2 diabetes mellitus (T2DM) is a serious public health problem. A growing body of evidence suggests that consumption of caffeine leads to disruptions of glucose metabolism that could be of concern for both the development of T2DM and its clinical management. At least 17 studies have consistently demonstrated that caffeine administration in healthy, nondiabetic adults produces an acute increase in insulin resistance or impairment of glucose tolerance, an effect that could contribute to T2DM disease progression in susceptible individuals. Studies of coffee drinkers who have T2DM have found that caffeine exaggerates the rise in glucose after carbohydrate ingestion, an effect that could contribute to higher chronic glucose levels and impaired clinical control. The results of these well-controlled experimental studies contradict epidemiological studies that find that heavy coffee drinking is associated with a lower risk of T2DM. Although it is premature to recommend caffeine abstinence for patients with T2DM and for those at risk, the evidence is sufficient to warrant further study of caffeine's effects, including clinical trials of the potential benefits of eliminating caffeine from the diet.

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Section: Relevance Of the Experimental Results To Understanding The Csupporting

confidence: 78%

Section: Caffeine Effects On Insulin Resistancementioning

confidence: 99%

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Caffeine, Glucose Metabolism, and Type 2 Diabetes

Lane

2011

Journal of Caffeine Research

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“…1 This observation was regarded paradoxical, as acute administration of caffeine leads to the deterioration of the glucose tolerance. 2, 3, 4 The results of the Hoorn study were confirmed and extended by data from the Nurses health study and the Health professionals' follow-up study. 5 …”

Section: Introductionmentioning

confidence: 61%

Effect of chronic coffee consumption on weight gain and glycaemia in a mouse model of obesity and type 2 diabetes

et al. 2014

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Objective:Epidemiological evidence shows that chronic coffee consumption in humans is correlated with a lower incidence of type 2 diabetes mellitus. For the experimental exploration of the underlying mechanisms, this effect needs to be replicated in an animal model of type 2 diabetes with a short lifespan.Design:Male C57BL/6 mice consumed regular coffee or water ad libitum and the development of obesity and diabetes caused by high-fat diet (55% lipids, HFD) was observed from week 10 on for 35 weeks in comparison with mice feeding on a defined normal diet (9% lipids, ND).Results:The massive weight gain in HFD mice was dose-dependently retarded (P=0.034), the moderate weight gain in ND mice was abolished (P<0.001) by coffee consumption, probably because of a lower feeding efficiency. The consumption of fluid (water or coffee) was significantly diminished by HFD (P<0.001), resulting in a higher coffee exposure of ND mice. On week 21 intraperitoneal glucose tolerance tests (IPGTT) showed a dose-dependent faster decline of elevated glucose levels in coffee-consuming HFD mice (P=0.016), but not in ND mice. Remarkably, a spontaneous decrease in non-fasting glycaemia occurred after week 21 in all treatment groups (P<0.001). On week 39 the IPGTT showed diminished peak of glucose levels in coffee-consuming HFD mice (P<0.05). HFD mice were hyperinsulinaemic and had significantly (P<0.001) enlarged islets. Coffee consumption did not affect islet size or parameters of beta-cell apoptosis, proliferation and insulin granule content.Conclusion:Coffee consumption retarded weight gain and improved glucose tolerance in a mouse model of type 2 diabetes and corresponding controls. This gives rise to the expectation that further insight into the mechanism of the diabetes-preventive effect of coffee consumption in humans may be gained by this approach.

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“…Early studies investigating the effects of methylxanthines on glucose homeostasis in response to a glucose challenge in humans were descriptive in nature, reported inconsistent findings, and were fraught with methodological problems (13)(14)(15)(16)(17). More recent investigations have also produced conflicting results.…”

mentioning

confidence: 99%

Caffeine Ingestion Decreases Glucose Disposal During a Hyperinsulinemic-Euglycemic Clamp in Sedentary Humans

et al. 2001

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The purpose of this investigation was to examine the effect of caffeine (an adenosine receptor antagonist) on whole-body insulin-mediated glucose disposal in resting humans. We hypothesized that glucose disposal would be lower after the administration of caffeine compared with placebo. Healthy, lean, sedentary (n ‫؍‬ 9) men underwent two trial sessions, one after caffeine administration (5 mg/kg body wt) and one after placebo administration (dextrose) in a double-blind randomized design. Glucose disposal was assessed using a hyperinsulinemic-euglycemic clamp. Before the clamp, there were no differences in circulating levels of methylxanthines, catecholamines, or glucose. Euglycemia was maintained throughout the clamp with no difference in plasma glucose concentrations between trials. The insulin concentrations were also similar in the caffeine and placebo trials. After caffeine administration, glucose disposal was 6.38 ؎ 0.76 mg/kg body wt compared with 8.42 ؎ 0.63 mg/kg body wt after the placebo trial. This represents a significant (P < 0.05) decrease (24%) in glucose disposal after caffeine ingestion. In addition, carbohydrate storage was 35% lower (P < 0.05) in the caffeine trial than in the placebo trial. Furthermore, even when the difference in glucose disposal was normalized between the trials, there was a 23% difference in the amount of carbohydrate stored after caffeine administration compared with placebo administration. Caffeine ingestion also resulted in higher plasma epinephrine levels than placebo ingestion (P < 0.05). These data support our hypothesis that caffeine ingestion decreases glucose disposal and suggests that adenosine plays a role in regulating glucose disposal in resting humans.

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Effects of coffee ingestion on oral glucose tolerance curves in normal human subjects

Cited by 49 publications

References 29 publications

Caffeine, Glucose Metabolism, and Type 2 Diabetes

Caffeine, Glucose Metabolism, and Type 2 Diabetes

Effect of chronic coffee consumption on weight gain and glycaemia in a mouse model of obesity and type 2 diabetes

Caffeine Ingestion Decreases Glucose Disposal During a Hyperinsulinemic-Euglycemic Clamp in Sedentary Humans

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