Caffeine Ingestion Decreases Glucose Disposal During a Hyperinsulinemic-Euglycemic Clamp in Sedentary Humans

Greer, Felicia; Hudson, Robert; Ross, Robert; Graham, Terry E.

doi:10.2337/diabetes.50.10.2349

Cited by 190 publications

(158 citation statements)

References 42 publications

(48 reference statements)

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“…Ingestion of caffeine at a dose equivalent to drinking 3-4 cups of coffee decreased whole-body glucose disposal by 30%, in agreement with our previous report (22) (Fig. 1).…”

Section: Discussionsupporting

confidence: 82%

“…In rat adipocytes (20) and in the perfused contracting rat hindlimb (21), methylxanthines inhibited insulin-stimulated glucose uptake, and this inhibitory action was attributed to the antagonistic effects of methylxanthine on the A 1 adenosine receptor. We have previously shown that caffeine administration at doses eliciting plasma concentrations equivalent to concentrations obtainable after drinking 3-4 cups of coffee (19) decreased whole-body insulin sensitivity in sedentary males (22). However, it is not known whether the reduction in whole-body glucose disposal after caffeine ingestion resulted from diminished glucose uptake in skeletal muscle.…”

mentioning

confidence: 99%

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Caffeine-Induced Impairment of Insulin Action but Not Insulin Signaling in Human Skeletal Muscle Is Reduced by Exercise

et al. 2002

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We investigated the effects of caffeine ingestion on skeletal muscle glucose uptake, glycogen synthase (GS) activity, and insulin signaling intermediates during a 100-min euglycemic-hyperinsulinemic (100 U/ml) clamp. On two occasions, seven men performed 1-h one-legged knee extensor exercise at 3 h before the clamp. Caffeine (5 mg/kg) or placebo was administered in a randomized, double-blind fashion 1 h before the clamp. During the clamp, whole-body glucose disposal was reduced (P < 0.05) in caffeine (37.5 ؎ 3.1 mol ⅐ min ؊1 ⅐ kg ؊1 ) vs. placebo (54.1 ؎ 2.9 mol ⅐ min ؊1 ⅐ kg ؊1 ). In accordance, the total area under the curve over 100 min (AUC 0 -100 min ) for insulin-stimulated glucose uptake in caffeine was reduced (P < 0.05) by ϳ50% in rested and exercised muscle. Caffeine also reduced (P < 0.05) GS activity before and during insulin infusion in both legs. Exercise increased insulin sensitivity of leg glucose uptake in both caffeine and placebo. Insulin increased insulin receptor tyrosine kinase (IRTK), insulin receptor substrate 1-associated phosphatidylinositol (PI) 3-kinase activities, and Ser 473 phosphorylation of protein kinase B (PKB)/Akt significantly but similarly in rested and exercised legs. Furthermore, insulin significantly decreased glycogen synthase kinase-3␣ (GSK-3␣) activity equally in both legs. Caffeine did not alter insulin signaling in either leg. Plasma epinephrine and muscle cAMP concentrations were increased in caffeine. We conclude that 1) caffeine impairs insulin-stimulated glucose uptake and GS activity in rested and exercised human skeletal muscle; 2) caffeine-induced impairment of insulin-stimulated muscle glucose uptake and downregulation of GS activity are not accompanied by alterations in IRTK, PI 3-kinase, PKB/Akt, or GSK-3␣ but may be associated with increases in epinephrine and intramuscular cAMP concentrations; and 3) exercise reduces the detrimental effects of caffeine on insulin action in muscle. Diabetes 51:583-590, 2002

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“…Ingestion of caffeine at a dose equivalent to drinking 3-4 cups of coffee decreased whole-body glucose disposal by 30%, in agreement with our previous report (22) (Fig. 1).…”

Section: Discussionsupporting

confidence: 82%

mentioning

confidence: 99%

Caffeine-Induced Impairment of Insulin Action but Not Insulin Signaling in Human Skeletal Muscle Is Reduced by Exercise

et al. 2002

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“…Coffee and tea consumption may affect serum uric acid levels via various mechanisms including influence on insulin resistance (2)(3)(4)(5)(6)(7)(8)(9), but few data are available. Only 1 cross-sectional study investigated the link between these beverages and serum uric acid level based on 2,240 Japanese men and found a significant inverse association between coffee consumption and serum uric acid levels but no association with tea consumption (10).…”

Section: Introductionmentioning

confidence: 99%

Coffee, tea, and caffeine consumption and serum uric acid level: The third national health and nutrition examination survey

Choi

Curhan

2007

Arthritis & Rheumatism

208

122

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Objective. Coffee is one of the most widely consumed beverages in the world and may affect serum uric acid levels and risk of gout via various mechanisms. Our objective was to evaluate the relationship between coffee, tea, and caffeine intake and serum uric acid level in a nationally representative sample of men and women. Methods. Using data from 14,758 participants ages >20 years in the Third National Health and Nutrition Examination Survey (1988 -1994), we examined the relationship between coffee, tea, and caffeine intake and serum uric acid level using linear regression. Additionally, we examined the relationship with hyperuricemia (serum uric acid >7.0 mg/dl among men and >5.7 mg/dl among women) using logistic regression. Intake was assessed by a food frequency questionnaire. Results. Serum uric acid level decreased with increasing coffee intake. After adjusting for age and sex, serum uric acid level associated with coffee intake of 4 to 5 and >6 cups daily was lower than that associated with no intake by 0.26 mg/dl (95% confidence interval [95% CI] 0.11, 0.41) and 0.43 mg/dl (95% CI 0.23, 0.65; P for trend < 0.001), respectively. After adjusting for other covariates, the differences remained significant (P for trend < 0.001). Similarly, there was a modest inverse association between decaffeinated coffee intake and serum uric acid levels (multivariate P for trend 0.035). Total caffeine from coffee and other beverages and tea intake were not associated with serum uric acid levels (multivariate P for trend 0.15). The multivariate odds ratio for hyperuricemia in individuals with coffee intake >6 cups daily compared with those with no coffee use was 0.57 (95% CI 0.35, 0.94; P for trend 0.001). Conclusion. These findings from a nationally representative sample of US adults suggest that coffee consumption is associated with lower serum uric acid level and hyperuricemia frequency, but tea consumption is not. The inverse association with coffee appears to be via components of coffee other than caffeine.

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“…In contrast, short-term studies have consistently shown that acute administration of caffeine induces insulin resistance and impairs glucose tolerance (3,5,6). Longterm effects of caffeine and other components of coffee, which may be more relevant on insulin secretion, have been less well studied.…”

mentioning

confidence: 97%

Caffeinated Coffee, Decaffeinated Coffee, and Caffeine in Relation to Plasma C-Peptide Levels, a Marker of Insulin Secretion, in U.S. Women

Wu¹,

et al. 2005

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OBJECTIVE -Coffee consumption is associated with reduced risk of type 2 diabetes, but the mechanism is not clearly understood. Elevated C-peptide, as a marker of insulin secretion, has been linked to insulin-resistant type 2 diabetes. In this study, we examined consumption of caffeinated and decaffeinated coffee and total caffeine in relation to concentrations of plasma C-peptide.RESEARCH DESIGN AND METHODS -Plasma C-peptide concentrations were measured in a cross-sectional setting among 2,112 healthy women from the Nurses' Health Study I who provided blood samples in 1989 -1990. Consumption of caffeinated and decaffeinated coffee and total caffeine was assessed using a semiquantitative food-frequency questionnaire in 1990.RESULTS -Intakes of caffeinated and decaffeinated coffee and caffeine in 1990 were each inversely associated with C-peptide concentration in age-adjusted, BMI-adjusted, and multivariable-adjusted analyses. In multivariable analysis, concentrations of C-peptide were 16% less in women who drank Ͼ4 cups/day of caffeinated or decaffeinated coffee compared with nondrinkers (P Ͻ 0.005 for each). Women in the highest quintile compared with the lowest quintile of caffeine intake had 10% lower C-peptide levels (P ϭ 0.02). We did not find any association between tea and C-peptide. The inverse association between caffeinated coffee and C-peptide was considerably stronger in obese (27% reduction) and overweight women (20% reduction) than in normal weight women (11% reduction) (P ϭ 0.005).CONCLUSIONS -Our findings suggest a potential reduction of insulin secretion by coffee in women. This reduction may be related to other components in coffee rather than caffeine. Diabetes Care 28:1390 -1396, 2005C offee intake has been associated with a reduction in the risk of type 2 diabetes (1-4). Because of its widespread consumption, understanding the relationship between coffee intake and insulin secretion may have implications in the prevention and treatment of diabetes.In contrast, short-term studies have consistently shown that acute administration of caffeine induces insulin resistance and impairs glucose tolerance (3,5,6). Longterm effects of caffeine and other components of coffee, which may be more relevant on insulin secretion, have been less well studied. In a recent crosssectional study of 936 elderly men without diabetes, coffee was associated with increased insulin sensitivity but not with decreased secretion (7). However, this study did not distinguish between caffeinated and decaffeinated coffee, did not study women, and measured only the early insulin response under glucose stimulation.C-peptide is cleaved from proinsulin and released into the bloodstream in equivalent amounts with insulin (8). Increased C-peptide has been associated with insulin resistance and diabetes (9), cardiovascular disease (10), and colon cancer (11). According to the National Coffee Association, 54% of adults in the U.S. drank coffee in 2000, with average per capita daily consumption of 1.9 cups for men and 1.4 cups for women...

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Caffeine Ingestion Decreases Glucose Disposal During a Hyperinsulinemic-Euglycemic Clamp in Sedentary Humans

Cited by 190 publications

References 42 publications

Caffeine-Induced Impairment of Insulin Action but Not Insulin Signaling in Human Skeletal Muscle Is Reduced by Exercise

Caffeine-Induced Impairment of Insulin Action but Not Insulin Signaling in Human Skeletal Muscle Is Reduced by Exercise

Coffee, tea, and caffeine consumption and serum uric acid level: The third national health and nutrition examination survey

Caffeinated Coffee, Decaffeinated Coffee, and Caffeine in Relation to Plasma C-Peptide Levels, a Marker of Insulin Secretion, in U.S. Women

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