Effects of Codonopis bulleynana forest ex diels on Deferribacteres in constipation predominant intestine tumor: Differential analysis

Li, Yanmei; Luan, Yunpeng; Yue, Xiao‐Guang; Fei, Xiang; Mao, Dechang; Cao, Yong; Xiong, Zichang

doi:10.1016/j.sjbs.2018.11.008

Cited by 26 publications

(20 citation statements)

References 24 publications

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“…Deferribacteres bacteria are able to obtain energy through obligate or facultative anaerobic metabolism. The iron metabolism of Deferribacteres in intestinal flora has been shown to be related to iron balance in the gastrointestinal tract (54). By analogy, we infer that FP also may be related to iron metabolism.…”

Section: Discussionmentioning

confidence: 71%

Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice

et al. 2020

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The bacterium Flavonifractor plautii (FP), which is found in human feces, has been reported to participate in catechin metabolism in the gut, but this bacterium's effects on immune function are unclear. We assessed the effect of oral administration of FP on the immune response in ovalbumin (OVA) -sensitized mice. We demonstrated that the FP treatment suppressed interleukin (IL)-4 in splenocytes and OVA-specific IgE production in serum from OVA-sensitized mice. Moreover, oral administration of FP augmented CD4 + CD25 + T cells and CD103 + CD11c + DCs. In animals of the FP group, the proportion of FP was increased in the mesenteric lymph nodes (MLNs), as was the proportion of Deferribacteres in the cecum. Oral administration of FP may inhibit the Th2 immune response by incorporation into the MLNs and/or by inducing changes in the gut microbiota. Thus, FP may be useful in alleviating antigen-induced Th2 immune responses.

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Section: Discussionmentioning

confidence: 71%

Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice

et al. 2020

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“…The research of Li et al. (2019) also showed that the abundance of Proteobacteria was lower in the constipation‐predominant intestine tumor group than the control group. Additionally, the Desulfovibrionales are an order of Proteobacteria , which may be the main reason for the difference of Proteobacteria levels among the groups.…”

Section: Discussionmentioning

confidence: 93%

Gut microbiota is involved in the alleviation of loperamide‐induced constipation by honey supplementation in mice

Long

Liu

et al. 2020

Food Science & Nutrition

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Constipation is one of the most common functional gastrointestinal disorders accompanied with intestinal dysbiosis. Laxatives for constipation usually have side effects. Bee honey is a natural food with unique composition, antimicrobial properties, and bifidogenic effect. In order to assess whether honey can ameliorate loperamide‐induced constipation in BALB/c mice through the alteration of the gut microbiota, the present study was undertaken. Mice were given Jarrah honey (7.5 g/kg body weight) by gavage once per day for 5 days. Fecal water content, intestinal transit rate together with the colon concentrations of substance P (SP), vasoactive intestinal peptide (VIP), and serotonin (5‐hydroxytryptamine; 5‐HT) were evaluated. Furthermore, we determined the effect of honey treatment on gut microbiota in mice using stool genomic 16S rRNA sequencing. As a result, honey showed an obvious improvement in fecal water content and alleviated constipation by modulating the microbial composition of the microbiota, and this was highly associated with a proportional decrease in gut Desulfovibrio. In addition, we found that the colon level of neurotransmitters SP and VIP was significantly related to microbial variations. Our results indicate that gut microbiota is involved in the alleviation of loperamide‐induced constipation by honey supplementation in mice, and it could be considered as an evaluating parameter in constipation therapy strategies.

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“…In standard diet mice, the relative abundance of the phylum Deferribacteres was significantly higher after Pg administration. The phylum Deferribacteres is involved in iron metabolism, 45 and abnormal iron metabolism was F I G U R E 7 Co-occurrence network in the gut microbiome (n = 4). Co-occurrence patterns are drawn using a network structure in which each taxon and co-occurrence of genus level was indicated by a node and edge, respectively, for all taxa of genus level pairs with a positive correlation.…”

Section: Discussionmentioning

confidence: 99%

Porphyromonas gingivalis impairs glucose uptake in skeletal muscle associated with altering gut microbiota

et al. 2020

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Skeletal muscles have a high metabolic capacity, which play key roles in glucose metabolism. Although periodontal disease increases the risk of metabolic syndrome, the relationship between periodontal bacterial infection and skeletal muscle metabolic dysfunction is unclear. We found that anti-Porphyromonas gingivalis (Pg) antibody titers positively correlated with intramuscular adipose tissue content (IMAC), fasting blood glucose, and HOMA-IR in metabolic syndrome patients. In C57BL/6J mice fed a high-fat diet, recipients of oral Pg (HFPg) had impaired glucose tolerance, insulin resistance, and higher IMAC compared to recipients of saline (HFco). The soleus muscle in HFPg mice exhibited fat infiltration and lower glucose uptake with higher Tnfa expression and lower insulin signaling than in HFco mice. Gene set enrichment analysis showed that TNFα signaling via NFκB gene set was enriched in the soleus muscle of HFPg mice.Moreover, TNF-α also decreased glucose uptake in C2C12 myoblast cells in vitro.

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Effects of Codonopis bulleynana forest ex diels on Deferribacteres in constipation predominant intestine tumor: Differential analysis

Cited by 26 publications

References 24 publications

Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice

Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice

Gut microbiota is involved in the alleviation of loperamide‐induced constipation by honey supplementation in mice

Porphyromonas gingivalis impairs glucose uptake in skeletal muscle associated with altering gut microbiota

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