Effects of amitriptyline, a tricyclic antidepressant, on smooth muscle reactivity of isolated rat trachea A short title: Amitriptyline and airway smooth muscle relaxation Key Words: Rats, Airway smooth muscle, Contractile response, Amitriptyline, Rho-kinase pathway, Phosphatidylinositol response 3
AbstractPurpose. This study was designed to investigate the action of amitriptyline, a tricyclic antidepressant, on airway smooth muscle reactivity and its underlying mechanisms.